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TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50254806(CHEMBL4066399)
Affinity DataEC50:  3.30E+3nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50254814(CHEMBL4059912)
Affinity DataEC50:  8nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255141(CHEMBL4076939)
Affinity DataEC50:  3.70E+3nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255155(CHEMBL4097424)
Affinity DataEC50:  840nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255163(CHEMBL4067770)
Affinity DataEC50:  30nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255165(CHEMBL4071952)
Affinity DataEC50:  60nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255210(CHEMBL4082801)
Affinity DataEC50:  410nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255167(CHEMBL4066751)
Affinity DataEC50:  150nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255168(CHEMBL4094277)
Affinity DataEC50:  2.30E+3nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255173(CHEMBL4097937)
Affinity DataEC50:  12nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255160(CHEMBL4089699)
Affinity DataEC50:  340nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50254801(CHEMBL4104102)
Affinity DataEC50:  30nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255162(CHEMBL4105353)
Affinity DataEC50:  70nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50332136((S)-2-phenyl-4-(piperidin-3-ylamino)thieno[3,2-c]p...)
Affinity DataEC50:  26nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50254810(CHEMBL4100776)
Affinity DataEC50:  50nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255164(CHEMBL4096683)
Affinity DataEC50:  53nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255161(CHEMBL4081097)
Affinity DataEC50:  390nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255214(CHEMBL4088986)
Affinity DataEC50:  40nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50254805(CHEMBL4093952)
Affinity DataEC50:  10nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255213(CHEMBL4068572)
Affinity DataEC50:  210nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255216(CHEMBL4081827)
Affinity DataEC50:  880nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255178(CHEMBL4079910)
Affinity DataEC50:  10nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255208(CHEMBL4098878)
Affinity DataEC50:  24nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255144(CHEMBL4079391)
Affinity DataEC50:  110nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50243258((S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophe...)
Affinity DataEC50:  19nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255177(CHEMBL4104408)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499822(CHEMBL3740897)
Affinity DataEC50:  53nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499823(CHEMBL3742411)
Affinity DataEC50:  115nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499824(CHEMBL3740017)
Affinity DataEC50:  216nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499825(CHEMBL3741716)
Affinity DataEC50:  87nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499826(CHEMBL3740722)
Affinity DataEC50:  311nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499827(CHEMBL3742184)
Affinity DataEC50:  573nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499828(CHEMBL3740068)
Affinity DataEC50:  140nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499829(CHEMBL3741945)
Affinity DataEC50:  57nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499821(CHEMBL3740104)
Affinity DataEC50: <18nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499822(CHEMBL3740897)
Affinity DataEC50:  30nMAssay Description:Inhibition of PARP in human MDA-MB-157 cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM209856(US9273052, 15 | US9566277, 15)
Affinity DataEC50:  51nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499821(CHEMBL3740104)
Affinity DataEC50:  123nMAssay Description:Inhibition of PARP in multi-drug resistant human MCF7 cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based imag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499821(CHEMBL3740104)
Affinity DataEC50:  3nMAssay Description:Inhibition of PARP in human MDA-MB-468 cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499830(CHEMBL3740177)
Affinity DataEC50:  49nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499831(CHEMBL3742396)
Affinity DataEC50:  27nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499832(CHEMBL3740950)
Affinity DataEC50: >1.10E+4nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499833(CHEMBL3740784)
Affinity DataEC50:  9.18E+3nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499822(CHEMBL3740897)
Affinity DataEC50:  30nMAssay Description:Inhibition of PARP in human HCC1806 cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499822(CHEMBL3740897)
Affinity DataEC50:  123nMAssay Description:Inhibition of PARP in human MCF7 cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499834(CHEMBL3741280)
Affinity DataEC50: <15nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499835(CHEMBL3739469)
Affinity DataEC50: >1.10E+4nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499836(CHEMBL3739814)
Affinity DataEC50:  5.04E+3nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499837(CHEMBL3740510)
Affinity DataEC50:  102nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499838(CHEMBL3740189)
Affinity DataEC50:  9.33E+3nMAssay Description:Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
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