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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM103622(US8551963, I-1)
Affinity DataKd:  0.680nMAssay Description:Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM103622(US8551963, I-1)
Affinity DataKd:  1.90nMAssay Description:Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM103622(US8551963, I-1)
Affinity DataKd:  5.5nMAssay Description:Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM103622(US8551963, I-1)
Affinity DataKd:  0.690nMAssay Description:Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM103622(US8551963, I-1)
Affinity DataKd:  0.770nMAssay Description:Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM103623(US8551963, 1a)
Affinity DataKd:  1.60nMAssay Description:Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM103623(US8551963, 1a)
Affinity DataKd:  3.70nMAssay Description:Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM103623(US8551963, 1a)
Affinity DataKd:  7.10nMAssay Description:Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM103623(US8551963, 1a)
Affinity DataKd:  2.20nMAssay Description:Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM103623(US8551963, 1a)
Affinity DataKd:  4.10nMAssay Description:Competition binding assay used herein were developed validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333480(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Affinity DataKd:  29nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333626(1-(4- chlorophenyl)-3- (3-(6,7- dimethoxy- quinazo...)
Affinity DataKd:  30nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333571(1-(3-tert- butylphenyl)- 3-(3-(6,7- dimethoxy- qui...)
Affinity DataKd:  36nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333478(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Affinity DataKd:  38nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333632(1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)...)
Affinity DataKd:  46nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333561(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-hydroxy- ...)
Affinity DataKd:  46nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333817(1-(5-tert- butylisoxazol- 3-yl)-3-(5-(6,7- dimetho...)
Affinity DataKd:  56nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333504(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6,7- dimeth...)
Affinity DataKd:  61nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333469(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-ethoxy-7-...)
Affinity DataKd:  67nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333445(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6,7- dimeth...)
Affinity DataKd:  72nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333443(1-(5-tert- butylisoxazol- 3-yl)-3-[3- (7-ethoxy-6-...)
Affinity DataKd:  82nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333629(1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)...)
Affinity DataKd:  90nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333749(1-(5-tert- butylisoxazol- 3-yl)-3- (2-chloro-5-(6,...)
Affinity DataKd:  99nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50340933(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Affinity DataKd:  370nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50484268(CHEMBL1824071)
Affinity DataKd:  478nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333740(1-(5-tert- butylisoxdazol- 3-yl)- 3-(3-(6,7- dimet...)
Affinity DataKd:  38nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333550(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-hydroxy- ...)
Affinity DataKd:  57nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50484269(CHEMBL1824068)
Affinity DataKd:  40nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333473(1-(5-tert- butylisoxazol- 3-yl)-3-{3- [7-methoxy- ...)
Affinity DataKd:  48nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333444(1-(5-tert- Butylisoxazol- 3-yl)-3-{3- [6-methoxy- ...)
Affinity DataKd:  57nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333442(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6,7- dimeth...)
Affinity DataKd:  73nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333624(1-(4-tert- butylphenyl)- 3-(3-(6,7- dimethoxy- qui...)
Affinity DataKd:  96nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  284nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333474(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Affinity DataKd:  96nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333720(1-(5-tert- butylisoxazol- 3-yl)- 3-(5- (6,7- dimet...)
Affinity DataKd:  46nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333627(1-(4-chloro-3- (trifluoromethyl) phenyl)- 3-(3-(6,...)
Affinity DataKd:  98nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333485(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- ...)
Affinity DataKd:  56nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333493(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- ...)
Affinity DataKd:  34nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155694(1-{2-Hydroxy-3-methyl-4-[3-(pyridin-4-ylsulfanylme...)
Affinity DataEC50:  819nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155695(1-{2-Hydroxy-3-methyl-4-[2-(pyridin-4-ylsulfanyl)-...)
Affinity DataEC50:  677nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155696(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-4-ylsulfanyl)-...)
Affinity DataEC50:  578nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155697(1-[3-Bromo-2-hydroxy-4-(4-phenoxy-butoxy)-phenyl]-...)
Affinity DataEC50:  1.50E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155698(1-{3-Bromo-2-hydroxy-4-[4-(pyridin-4-ylsulfanyl)-b...)
Affinity DataEC50:  676nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155699(1-{3-Bromo-4-[4-(2,3-difluoro-phenoxy)-butoxy]-2-h...)
Affinity DataEC50:  558nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155701(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-4-ylsulfanyl)-...)
Affinity DataEC50:  340nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155700(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-3-yloxy)-butox...)
Affinity DataEC50:  1.72E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155702(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-2-yloxy)-butox...)
Affinity DataEC50:  3.27E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130608(2,2,2-Trifluoro-ethanesulfonic acid [4-(2-methoxy-...)
Affinity DataEC50:  1.70E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155703(1-{2-Hydroxy-3-methyl-4-[3-(pyridin-4-ylsulfanyl)-...)
Affinity DataEC50:  890nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153757(1-(2-Hydroxy-3-propyl-4-{4-[4-(1H-tetrazol-5-yl)-p...)
Affinity DataEC50:  348nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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