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Found 12467 with Last Name = 'joh' and Initial = 'j'
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029704(2-(4-Benzyl-5-oxo-2,5-dihydro-furan-3-yloxymethyl)...)
Affinity DataKi:  0.0130nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029709(2-(4-Benzyl-2-methyl-5-oxo-2,5-dihydro-furan-3-ylo...)
Affinity DataKi:  0.0160nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189451(US9174974, Example 39)
Affinity DataKi:  0.0200nMAssay Description:FVIIa-Xase Ki (37 C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029710(4-Isopropyl-6-methoxy-2-(2-methyl-5-oxo-4-phenyl-2...)
Affinity DataKi:  0.0210nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029699(2,6-Dichloro-benzoic acid 4-isopropyl-6-methoxy-1,...)
Affinity DataKi:  0.0230nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029698(4-Isopropyl-6-methoxy-1,1-dioxo-2-(5-oxo-4-phenyl-...)
Affinity DataKi:  0.0250nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029717(2-(3-Chloro-6-methyl-2-oxo-2H-pyran-4-yloxymethyl)...)
Affinity DataKi:  0.0250nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029696(2-(3-Benzoyl-6-methyl-2-oxo-2H-pyran-4-yloxymethyl...)
Affinity DataKi:  0.0270nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029712(2-(4-Chloro-5-oxo-2,5-dihydro-furan-3-yloxymethyl)...)
Affinity DataKi:  0.0300nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442922(CHEMBL3086984)
Affinity DataKi:  0.0310nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442927(CHEMBL3086994)
Affinity DataKi:  0.0320nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029713(4-Isopropyl-6-methoxy-1,1-dioxo-2-(3-oxo-cyclobut-...)
Affinity DataKi:  0.0330nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029691(2-(2-Benzyl-3-oxo-cyclopent-1-enyloxymethyl)-4-iso...)
Affinity DataKi:  0.0340nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442921(CHEMBL3086985)
Affinity DataKi:  0.0430nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442924(CHEMBL3086982)
Affinity DataKi:  0.0460nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442930(CHEMBL3086991)
Affinity DataKi:  0.0490nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029692(4-Isopropyl-6-methoxy-2-(6-methyl-2-oxo-2H-pyran-4...)
Affinity DataKi:  0.0500nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189454(US9174974, Example 38)
Affinity DataKi:  0.0500nMAssay Description:FVIIa-Xase Ki (37 C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442926(CHEMBL3086995)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029695(4-Isopropyl-6-methoxy-1,1-dioxo-2-(5-oxo-2,5-dihyd...)
Affinity DataKi:  0.0520nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029711(3-Bromo-2-(4-isopropyl-6-methoxy-1,1,3-trioxo-1,3-...)
Affinity DataKi:  0.0580nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029720(4-Isopropyl-6-methoxy-2-(2-methyl-3-oxo-cyclopent-...)
Affinity DataKi:  0.0600nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)
Affinity DataKi:  0.0620nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029707(3-Chloro-2-(4-isopropyl-6-methoxy-1,1,3-trioxo-1,3...)
Affinity DataKi:  0.0660nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442928(CHEMBL3086993)
Affinity DataKi:  0.0720nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567169(CHEMBL4873876)
Affinity DataKi:  0.0740nMAssay Description:Displacement of [3H]Apelin-13 from human APJ receptor stably expressed in human HEK293 cell membrane incubated for 120 mins by TopCount scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442920(CHEMBL3086986)
Affinity DataKi:  0.0760nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029721(2-(4-Isopropyl-6-methoxy-1,1,3-trioxo-1,3-dihydro-...)
Affinity DataKi:  0.0780nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029715(4-Isopropyl-6-methoxy-1,1-dioxo-2-(3-oxo-3H-inden-...)
Affinity DataKi:  0.0830nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442929(CHEMBL3086992)
Affinity DataKi:  0.0830nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029718(4-Isopropyl-6-methoxy-1,1-dioxo-2-(2-oxo-2H-chrome...)
Affinity DataKi:  0.0900nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442923(CHEMBL3086983)
Affinity DataKi:  0.0930nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029700(4-Isopropyl-6-methoxy-2-(2-methyl-5-oxo-2,5-dihydr...)
Affinity DataKi:  0.0930nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50406007(CHEMBL418293)
Affinity DataKi:  0.100nMAssay Description:Apparent binding affinity of compound in Escherichia coli DHFRChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029706(2-(4-Isopropyl-6-methoxy-1,1,3-trioxo-1,3-dihydro-...)
Affinity DataKi:  0.110nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442932(CHEMBL3086989)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189450(US9174974, Example 36)
Affinity DataKi:  0.120nMAssay Description:FVIIa-Xase Ki (37 C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189447(US9174974, Example 33)
Affinity DataKi:  0.140nMAssay Description:FVIIa-Xase Ki (37 C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189448(US9174974, Example 34)
Affinity DataKi:  0.140nMAssay Description:FVIIa-Xase Ki (37 C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50029716(2-(1-Benzyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yloxymet...)
Affinity DataKi:  0.140nMAssay Description:Potency of inhibition of human leukocyte elastase is expressed as apparent binding constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189453(US9174974, Example 37)
Affinity DataKi:  0.140nMAssay Description:FVIIa-Xase Ki (37 C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50072110(3-((S)-1-Azetidin-2-ylmethoxy)-5-phenyl-pyridine |...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189449(US9174974, Example 35)
Affinity DataKi:  0.140nMAssay Description:FVIIa-Xase Ki (37 C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189446(US9174974, Example 32)
Affinity DataKi:  0.150nMAssay Description:FVIIa-Xase Ki (37 C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189445(US9174974, Example 31)
Affinity DataKi:  0.160nMAssay Description:Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189443(US9174974, Example 29)
Affinity DataKi:  0.170nMAssay Description:FVIIa-Xase Ki (37 C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014619(CHEMBL3184840)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]Apelin-13 from human APJ receptor stably expressed in human HEK293 cell membrane incubated for 120 mins by TopCount scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189445(US9174974, Example 31)
Affinity DataKi:  0.170nMAssay Description:FVIIa-Xase Ki (37 C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189444(US9174974, Example 30)
Affinity DataKi:  0.170nMAssay Description:FVIIa-Xase Ki (37 C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
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