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TargetReplicase polyprotein 1ab(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM23418((2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3...)
Affinity DataKd:  2.45E+4nMAssay Description:Binding affinity to SARS coronavirus 3C-like protease by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50259983(dieckol | CHEMBL508791 | US10106521, Compound Diec...)
Affinity DataKd:  1.03E+4nMAssay Description:Binding affinity to SARS coronavirus 3C-like protease by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50555357(CHEMBL1254751)
Affinity DataEC50:  1.25E+4nMAssay Description:Antagonist activity at PPARdelta LBD (unknown origin) assessed as increase in recruitment of SMRT ID2 corepressor peptide by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50555363(CHEMBL4758410)
Affinity DataEC50:  2.02E+4nMAssay Description:Antagonist activity at PPARdelta LBD (unknown origin) assessed as increase in recruitment of SMRT ID2 corepressor peptide by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50383373(GSK0660 | CHEMBL592652)
Affinity DataEC50:  4.34E+3nMAssay Description:Antagonist activity at PPARdelta LBD (unknown origin) assessed as increase in recruitment of SMRT ID2 corepressor peptide by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50555357(CHEMBL1254751)
Affinity DataEC50:  6.85E+3nMAssay Description:Agonist activity at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide fluorescein-TRAP220/DRIP by TR-FRET ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50555363(CHEMBL4758410)
Affinity DataEC50:  9.95E+3nMAssay Description:Agonist activity at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide fluorescein-TRAP220/DRIP by TR-FRET ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-benzoylphenylamino)-3-(4-(2-(methyl(pyrid...)
Affinity DataEC50:  17nMAssay Description:Agonist activity at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide fluorescein-TRAP220/DRIP by TR-FRET ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085045(5-((4-((6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-...)
Affinity DataEC50:  1.38E+3nMAssay Description:Agonist activity at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide fluorescein-TRAP220/DRIP by TR-FRET ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50421798(CHEMBL5268127)
Affinity DataEC50:  1.38E+4nMAssay Description:Agonist activity at PPARgamma in human BMMSC cells assessed as promotion of adiponectin secretion by measuring increase in adiponectin level in prese...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50421799(Altissimacoumarin D | ALTISSIMACOUMARIN D)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at PPARgamma in human BMMSC cells assessed as promotion of adiponectin secretion by measuring increase in adiponectin level in prese...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50361373(AURAPTENE)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at PPARgamma in human BMMSC cells assessed as promotion of adiponectin secretion by measuring increase in adiponectin level in prese...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM23926(5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol...)
Affinity DataEC50:  7.71E+4nMAssay Description:Agonist activity at PPARgamma in human BMMSC cells assessed as promotion of adiponectin secretion by measuring increase in adiponectin level in prese...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity at PPARgamma in human BMMSC cells assessed as promotion of adiponectin secretion by measuring increase in adiponectin level in prese...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataEC50:  200nMAssay Description:Agonist activity at PPARgamma in human BMMSC cells assessed as promotion of adiponectin secretion by measuring increase in adiponectin level in prese...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50421798(CHEMBL5268127)
Affinity DataEC50:  9.80E+3nMAssay Description:Agonist activity at GST-tagged PPAR-gamma ligand binding domain (unknown origin) assessed as recruitment of fluorescein-labeled SRC1 coactivator pept...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataEC50:  3.30E+3nMAssay Description:Agonist activity at GST-tagged PPAR-gamma ligand binding domain (unknown origin) assessed as recruitment of fluorescein-labeled SRC1 coactivator pept...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50421798(CHEMBL5268127)
Affinity DataEC50:  1.55E+4nMAssay Description:Agonist activity at GST-tagged PPAR-gamma ligand binding domain (unknown origin) assessed as recruitment of fluorescein-labeled SRC3 coactivator pept...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataEC50:  3.50E+3nMAssay Description:Agonist activity at GST-tagged PPAR-gamma ligand binding domain (unknown origin) assessed as recruitment of fluorescein-labeled SRC3 coactivator pept...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50421798(CHEMBL5268127)
Affinity DataEC50:  7.40E+3nMAssay Description:Agonist activity at GST-tagged PPAR-gamma ligand binding domain (unknown origin) assessed as recruitment of fluorescein-labeled PRIP/RAP250 coactivat...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataEC50:  900nMAssay Description:Agonist activity at GST-tagged PPAR-gamma ligand binding domain (unknown origin) assessed as recruitment of fluorescein-labeled PRIP/RAP250 coactivat...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50490819(CHEMBL2346913)
Affinity DataEC50: >3.00E+4nMAssay Description:Partial agonist activity at GST-tagged PPAR-gamma ligand binding domain (unknown origin) assessed as recruitment of fluorescein-labeled SRC1 coactiva...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50490819(CHEMBL2346913)
Affinity DataEC50: >3.00E+4nMAssay Description:Partial agonist activity at GST-tagged PPAR-gamma ligand binding domain (unknown origin) assessed as recruitment of fluorescein-labeled SRC3 coactiva...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50490819(CHEMBL2346913)
Affinity DataEC50:  1.73E+4nMAssay Description:Partial agonist activity at GST-tagged PPAR-gamma ligand binding domain (unknown origin) assessed as recruitment of fluorescein-labeled PRIP/RAP250 c...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50490819(CHEMBL2346913)
Affinity DataEC50:  2.58E+4nMAssay Description:Partial agonist activity at PPARgamma in human BMMSC cells assessed as promotion of adiponectin secretion by measuring increase in adiponectin level ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Reims Champagne-Ardenne

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human telomerase in A549 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459685(CHEMBL4209785)
Affinity DataIC50: 100nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Institut Pasteur Korea

Curated by ChEMBL
LigandPNGBDBM50022085(CHEMBL3298909)
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Reims Champagne-Ardenne

Curated by ChEMBL
LigandPNGBDBM50298376(4,5-Bis[3-(N,N-dimethylamino)propylaminomethyl]acr...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human telomerase in A549 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Institut Pasteur Korea

Curated by ChEMBL
LigandPNGBDBM50022080(CHEMBL3298837)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Institut Pasteur Korea

Curated by ChEMBL
LigandPNGBDBM50022083(CHEMBL3298907)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Institut Pasteur Korea

Curated by ChEMBL
LigandPNGBDBM50022084(CHEMBL3298908)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Institut Pasteur Korea

Curated by ChEMBL
LigandPNGBDBM50022085(CHEMBL3298909)
Affinity DataIC50: 290nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459697(CHEMBL4214693)
Affinity DataIC50: 360nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Institut Pasteur Korea

Curated by ChEMBL
LigandPNGBDBM50022083(CHEMBL3298907)
Affinity DataIC50: 380nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Institut Pasteur Korea

Curated by ChEMBL
LigandPNGBDBM50022079(CHEMBL3298836)
Affinity DataIC50: 490nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Institut Pasteur Korea

Curated by ChEMBL
LigandPNGBDBM50022078(CHEMBL3298835)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Institut Pasteur Korea

Curated by ChEMBL
LigandPNGBDBM50022081(CHEMBL3298905)
Affinity DataIC50: 570nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459699(CHEMBL4215206 | US12006283, Example 10)
Affinity DataIC50: 600nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Institut Pasteur Korea

Curated by ChEMBL
LigandPNGBDBM50022078(CHEMBL3298835)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1a(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM51317(1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dion...)
Affinity DataIC50: 700nMAssay Description:Inhibition of SARS-CoV PLpro deubiququitination expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459684(CHEMBL4206967)
Affinity DataIC50: 790nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1a(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM53072(3-Allyl-5-(3-ethyl-3H-benzothiazol-2-ylidene)-2-th...)
Affinity DataIC50: 800nMAssay Description:Inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459687(CHEMBL4211498)
Affinity DataIC50: 820nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459705(CHEMBL4218467)
Affinity DataIC50: 880nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459703(CHEMBL4210297)
Affinity DataIC50: 940nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459666(CHEMBL4205404)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1a(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50423877(Dihydrotanshinone I | DIHYDROTANSHINONE | acs.jmed...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of SARS-CoV PLpro deubiququitination expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459689(CHEMBL4206755)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Institut Pasteur Korea

Curated by ChEMBL
LigandPNGBDBM50022079(CHEMBL3298836)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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