Compile Data Set for Download or QSAR
Report error Found 3211 with Last Name = 'kos' and Initial = 't'
LigandPNGBDBM50268607(CHEMBL4060970)
Affinity DataEC50:  793nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268608(CHEMBL4072360)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268613(CHEMBL4099307)
Affinity DataEC50:  53nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268614(CHEMBL4098382)
Affinity DataEC50:  129nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268615(CHEMBL4065753)
Affinity DataEC50:  353nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268617(CHEMBL4093367)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268618(CHEMBL4083015)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268619(CHEMBL4100997)
Affinity DataEC50:  79nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268621(CHEMBL4101938)
Affinity DataEC50:  42nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268622(CHEMBL4077670)
Affinity DataEC50:  201nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268623(CHEMBL4063942)
Affinity DataEC50:  310nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268624(CHEMBL4085517)
Affinity DataEC50:  391nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268630(CHEMBL4086445)
Affinity DataEC50:  586nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268631(CHEMBL4104336)
Affinity DataEC50:  78nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268637(CHEMBL4094202)
Affinity DataEC50:  41nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268638(CHEMBL4080356)
Affinity DataEC50:  82nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268639(CHEMBL4099566)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268640(CHEMBL4066674)
Affinity DataEC50:  252nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268641(CHEMBL4079439)
Affinity DataEC50:  512nMAssay Description:Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luciferase incubated for 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50462180(CHEMBL149482)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human 5-HT1AR expressed in HEK293 cells assessed as increase in calcium flux by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50462141(CHEMBL4248491)
Affinity DataEC50:  11nMAssay Description:Partial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50462158(CHEMBL4239823)
Affinity DataEC50:  28nMAssay Description:Partial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  5.70nMAssay Description:Agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in calcium flux by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50467034(CHEMBL4294047)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467035(CHEMBL4277409)
Affinity DataEC50:  716nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467036(CHEMBL4283838)
Affinity DataEC50:  128nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467037(CHEMBL4294437)
Affinity DataEC50:  334nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467038(CHEMBL4279705)
Affinity DataEC50:  98nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467039(CHEMBL4276952)
Affinity DataEC50:  126nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467040(CHEMBL4286139)
Affinity DataEC50:  369nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467041(CHEMBL4284231)
Affinity DataEC50:  360nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467042(CHEMBL4290646)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467043(CHEMBL4288041)
Affinity DataEC50:  235nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467044(CHEMBL4291700)
Affinity DataEC50:  101nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50172073(CHEMBL3809509)
Affinity DataEC50:  54nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467045(CHEMBL4284899)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467046(CHEMBL4291039)
Affinity DataEC50:  142nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467047(CHEMBL4283180)
Affinity DataEC50:  56nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467048(CHEMBL4286549)
Affinity DataEC50:  321nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467049(CHEMBL4294852)
Affinity DataEC50:  46nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467050(CHEMBL4287616)
Affinity DataEC50:  68nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467051(CHEMBL4280383)
Affinity DataEC50:  169nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells after 4 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50605858(CHEMBL5203566)
Affinity DataKd:  500nMAssay Description:Binding affinity to Keap1 (unknown origin) expressed in Escherichia coli BL21 codon plus cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetKelch-like ECH-associated protein 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50605859(CHEMBL5207192)
Affinity DataKd:  429nMAssay Description:Binding affinity to Keap1 (unknown origin) expressed in Escherichia coli BL21 codon plus cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetKelch-like ECH-associated protein 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50593788(CHEMBL5172581)
Affinity DataKd:  429nMAssay Description:Binding affinity to Keap1 (unknown origin) expressed in Escherichia coli BL21 codon plus cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50605860(CHEMBL5174036)
Affinity DataKd:  429nMAssay Description:Binding affinity to Keap1 (unknown origin) expressed in Escherichia coli BL21 codon plus cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetKelch-like ECH-associated protein 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50605861(CHEMBL5195422)
Affinity DataKd:  429nMAssay Description:Binding affinity to Keap1 (unknown origin) expressed in Escherichia coli BL21 codon plus cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetKelch-like ECH-associated protein 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataKd:  39nMAssay Description:Binding affinity to Keap1 (unknown origin) expressed in Escherichia coli BL21 codon plus cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetKelch-like ECH-associated protein 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataKd:  20nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
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