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TargetD(1A) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50016792(SK-83566 | 8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetra...)
Affinity DataKd:  2.30nMAssay Description:In vitro binding affinity to the rat striatal homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50016795(CHEMBL287504 | 3-Methyl-5-phenyl-2,3,4,5-tetrahydr...)
Affinity DataKd:  197nMAssay Description:In vitro binding affinity to the rat striatal homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50016794(CHEMBL34170 | 8-Chloro-5-(4-iodo-phenyl)-3-methyl-...)
Affinity DataKd:  1.40nMAssay Description:In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005781(CHEBI:65324 | ALVESPIMYCIN)
Affinity DataEC50:  7.90nMAssay Description:Inhibition of Hsp90 in human A2058 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50479790(CHEMBL486547)
Affinity DataEC50:  41nMAssay Description:Inhibition of Hsp90 in human A2058 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50479788(CHEMBL486750)
Affinity DataEC50:  18nMAssay Description:Inhibition of Hsp90 in human A2058 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50038276(7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetrahydro...)
Affinity DataKd:  0.480nMAssay Description:Binding affinity was tested against dopamine receptor D3 in rat striatal membrane homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50020222(CHEMBL285755 | 7-Dipropylamino-5,6,7,8-tetrahydro-...)
Affinity DataKd:  0.670nMAssay Description:Tested for binding affinity against dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50043603(7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetrahydro...)
Affinity DataKd:  0.0500nMAssay Description:Binding affinity was tested against dopamine receptor D3 in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50038276(7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetrahydro...)
Affinity DataKd:  0.130nMAssay Description:Binding affinity was tested against dopamine receptor D3 in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM86708(CHEMBL31354 | CHEMBL514874 | NSC_104911 | CAS_1467...)
Affinity DataKd:  0.100nMAssay Description:In vitro binding affinity for 5-hydroxytryptamine 1A receptor was determined by measuring specific inhibition of [125I]-binding to rat hippocampal me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-alpha-acetyltransferase 50(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50541856(CHEMBL4635926)
Affinity DataKd:  1.01E+3nMAssay Description:Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in presence of acetyl CoA ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetN-alpha-acetyltransferase 50(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50541857(CHEMBL4633201)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in presence of acetyl CoA ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-alpha-acetyltransferase 50(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50541858(CHEMBL4645901)
Affinity DataKd:  27nMAssay Description:Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in presence of acetyl CoA ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-alpha-acetyltransferase 50(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50541859(CHEMBL4645967)
Affinity DataKd:  470nMAssay Description:Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in presence of acetyl CoA ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-alpha-acetyltransferase 50(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50541858(CHEMBL4645901)
Affinity DataKd:  32nMAssay Description:Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in presence of CoA by SPR ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-alpha-acetyltransferase 50(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50541859(CHEMBL4645967)
Affinity DataKd:  471nMAssay Description:Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in presence of CoA by SPR ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-alpha-acetyltransferase 50(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50541858(CHEMBL4645901)
Affinity DataKd:  105nMAssay Description:Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-alpha-acetyltransferase 50(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50541870(CHEBI:15351 | CHEMBL1230809)
Affinity DataKd:  18nMAssay Description:Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-alpha-acetyltransferase 50(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50367033(COENZYME_A)
Affinity DataKd:  156nMAssay Description:Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50005118(3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKd:  1.10nMAssay Description:Affinity constant of compound was evaluated in rat striatum tissue preparation.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50005118(3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKd:  7.10nMAssay Description:Affinity constant of compound was evaluated in human brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM11638(N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sul...)
Affinity DataKd:  1.5nMAssay Description:Affinity constant of compound was evaluated in rat striatum tissue preparation.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50020704(CHEMBL8475 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKd:  0.430nMAssay Description:Affinity constant of compound was evaluated in rat striatum tissue preparation.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50004813(8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-methyl-1-phe...)
Affinity DataKd:  0.0970nMAssay Description:Affinity constant of compound was evaluated in human brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataKd:  0.170nMAssay Description:Affinity constant of compound was evaluated in rat striatum tissue preparation.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012964(CHEMBL8945 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKd:  31nMAssay Description:Affinity constant of compound was evaluated in rat striatum tissue preparation.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50004813(8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-methyl-1-phe...)
Affinity DataKd:  0.0970nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50040082(N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulf...)
Affinity DataKd:  1.5nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012964(CHEMBL8945 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKd:  31nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataKd:  0.170nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012961(N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-3-iodo...)
Affinity DataKd:  0.430nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012966(CHEMBL49405 | 8-[4-(4-Fluoro-2-iodo-phenyl)-4-oxo-...)
Affinity DataKd:  0.25nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012967(N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2-methoxy...)
Affinity DataKd:  3nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012968(CHEMBL50154 | 4-Azido-N-(1-benzyl-piperidin-4-yl)-...)
Affinity DataKd:  14nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50007170(CHEMBL26533 | Adamantane-1-carboxylic acid {4-[4-(...)
Affinity DataKd:  0.400nMAssay Description:Inhibition of binding of [125I]-8-OH-PIPAT ligand to 5-hydroxytryptamine 1A receptor of rat hippocampal homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50035508(CHEMBL29027 | p-MPPI | 4-Iodo-N-{2-[4-(2-methoxy-p...)
Affinity DataKd:  0.300nMAssay Description:The binding of [125I]MPPI ligand to 5-hydroxytryptamine 1A receptor of rat hippocampal homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107856(2-(1-Methyl-pyrrolidin-2-yl)-chroman-7-ol | (+-)-2...)
Affinity DataEC50:  600nMAssay Description:Recovery following a 5 min wash after 10 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107858(2-(1-Methyl-piperidin-2-yl)-chroman-7-ol | (+-)-2-...)
Affinity DataEC50:  410nMAssay Description:Receptor activation after 100 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107856(2-(1-Methyl-pyrrolidin-2-yl)-chroman-7-ol | (+-)-2...)
Affinity DataEC50:  962nMAssay Description:Receptor activation after 100 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107856(2-(1-Methyl-pyrrolidin-2-yl)-chroman-7-ol | (+-)-2...)
Affinity DataEC50:  197nMAssay Description:Recovery following a 5 min wash after 100 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107858(2-(1-Methyl-piperidin-2-yl)-chroman-7-ol | (+-)-2-...)
Affinity DataEC50:  199nMAssay Description:Receptor activation after 10 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107858(2-(1-Methyl-piperidin-2-yl)-chroman-7-ol | (+-)-2-...)
Affinity DataEC50:  1.19E+3nMAssay Description:Recovery following a 5 min wash after 10 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107858(2-(1-Methyl-piperidin-2-yl)-chroman-7-ol | (+-)-2-...)
Affinity DataEC50:  851nMAssay Description:Recovery following a 5 min wash after 100 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193657(CHEMBL3955994)
Affinity DataKd:  37nMAssay Description:Binding affinity to EZH2 (unknown origin) expressed in baculovirus infected SF9 cells co-expressing SUZ12/EED/RbAp48 complex by ITC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193717(CHEMBL3932025)
Affinity DataKd:  252nMAssay Description:Binding affinity to EZH2 (unknown origin) expressed in baculovirus infected SF9 cells co-expressing SUZ12/EED/RbAp48 complex by ITC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246962(CHEMBL4080043 | US10570121, Example 1)
Affinity DataIC50: 1nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246944(CHEMBL4080606 | US10570121, Example 38)
Affinity DataIC50: 1nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50246932(CHEMBL4073864 | US10570121, Example 112)
Affinity DataIC50: 1nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM435691(US10570121, Example 198 | US10570121, Example 197)
Affinity DataIC50: 1nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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