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Found 1870 with Last Name = 'kung' and Initial = 'p'
TargetHistone acetyltransferase KAT7(Homo sapiens)
Pfizer

US Patent
LigandPNGBDBM580680(US11492346, Example 20)
Affinity DataKi:  0nMAssay Description:A. Compound preparation 1. Prepare 10 mM stock solutions in 100% DMSO from solid material 2. Serial dilute 10 mM, 1 mM or 0.1 mM compou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone acetyltransferase KAT6B(Homo sapiens)
Pfizer

US Patent
LigandPNGBDBM580734(US11492346, Example 74)
Affinity DataKi:  0nMAssay Description:A. Compound preparation 1. Prepare 10 mM stock solutions in 100% DMSO from solid material 2. Serial dilute 10 mM, 1 mM or 0.1 mM compou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50154364((6R,10bS)-6-(4-Methylsulfanyl-phenyl)-1,2,3,5,6,10...)
Affinity DataKi:  0.00900nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM435577(US10570121, Example 87)
Affinity DataKi:  0.0100nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM81987(CHEMBL116048 | McN-5652-15)
Affinity DataKi:  0.0100nMAssay Description:In vitro binding affinity of the compound against Serotonin transporter (SERT) from LLC-PK1 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(2-(2-((dimethylamino)methyl)phenylthio)-5-iodoanil...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM435691(US10570121, Example 197 | US10570121, Example 198)
Affinity DataKi:  0.0100nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.0150nMAssay Description:Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50040079(CHEMBL308524 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2...)
Affinity DataKi:  0.0190nMAssay Description:Inhibition constant against dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50008785(CHEMBL42953 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition constant against dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246932(CHEMBL4073864 | US10570121, Example 112)
Affinity DataKi:  0.0200nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50008782(CHEMBL44237 | EPIDEPRIDE | Epidepride;N-(1-Ethyl-p...)
Affinity DataKi:  0.0250nMAssay Description:Inhibition constant against dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50228440(5-chloro-2-(2-((dimethylamino)methyl)-4-(2-fluoroe...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [125I]5-iodo-2-[[2,2-[(dimethylamino)methyl]phenyl]thio]benzyl alcohol from SERT expressed in LLCPK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246939(CHEMBL4072089 | US10570121, Example 110)
Affinity DataKi:  0.0400nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50062262(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Affinity DataKi:  0.0450nMAssay Description:In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50228439(5-bromo-2-(2-((dimethylamino)methyl)-4-(2-fluoroet...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]5-iodo-2-[[2,2-[(dimethylamino)methyl]phenyl]thio]benzyl alcohol from SERT expressed in LLCPK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50039613((2R,3R)-3-(4-Phenyl-piperidin-1-yl)-1,2,3,4-tetrah...)
Affinity DataKi:  0.0550nMAssay Description:Binding to vesicular acetylcholine transporter of torpedo synaptic vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50062268(6-Iodo-2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-...)
Affinity DataKi:  0.0690nMAssay Description:In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50062268(6-Iodo-2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-...)
Affinity DataKi:  0.0690nMAssay Description:In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012965(5-Iodo-2,3-dihydro-benzofuran-7-carboxylic acid (1...)
Affinity DataKi:  0.0850nMAssay Description:Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50007518((S)-3-chloro-5-ethyl-N-((1-ethylpyrrolidin-2-yl)me...)
Affinity DataKi:  0.0900nMAssay Description:Compound was evaluated for the inhibition constant against dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073436((2-(2-((dimethylamino)methyl)phenylthio)-5-iodophe...)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073436((2-(2-((dimethylamino)methyl)phenylthio)-5-iodophe...)
Affinity DataKi:  0.0970nMAssay Description:In vitro binding affinity of the compound against Serotonin transporter (SERT) from LLC-PK1 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246967(CHEMBL4080228 | US10570121, Example 81)
Affinity DataKi: <0.100nMAssay Description:Binding affinity to EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM435609(US10570121, Example 118 | US10570121, Example 119)
Affinity DataKi:  0.100nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246940(CHEMBL4071056 | US10570121, Example 137)
Affinity DataKi:  0.100nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM435640(US10570121, Example 146 | US10570121, Example 147)
Affinity DataKi:  0.100nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM435642(US10570121, Example 148 | US10570121, Example 149 ...)
Affinity DataKi:  0.100nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM435694(US10570121, Example 200 | US10570121, Example 201)
Affinity DataKi:  0.100nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50228444(2-(2-((dimethylamino)methyl)-4-(2-fluoroethoxy)phe...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]5-iodo-2-[[2,2-[(dimethylamino)methyl]phenyl]thio]benzyl alcohol from SERT expressed in LLCPK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50040077(5-Iodo-2,3-dihydro-benzofuran-7-carboxylic acid [1...)
Affinity DataKi:  0.106nMAssay Description:Inhibition constant against dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101410((trans,trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4...)
Affinity DataKi:  0.110nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50154366(CHEMBL183470 | [2-(2-Dimethylaminomethyl-phenoxy)-...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101411(5-[2-bromo-4-(3-carboxy-4-hydroxyphenethyl)pheneth...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50039604((+)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidi...)
Affinity DataKi:  0.130nMAssay Description:Binding to vesicular acetylcholine transporter of torpedo synaptic vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100131(5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...)
Affinity DataKi:  0.140nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100131(5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...)
Affinity DataKi:  0.140nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50007521(5-Bromo-N-[1-(4-fluoro-benzyl)-pyrrolidin-2-ylmeth...)
Affinity DataKi:  0.147nMAssay Description:Inhibition constant against dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.149nMAssay Description:Inhibitory constant against binding of [125I]- IBZM to rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50228435(5-bromo-2-(2-((dimethylamino)methyl)-4-(3-fluoropr...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [125I]5-iodo-2-[[2,2-[(dimethylamino)methyl]phenyl]thio]benzyl alcohol from SERT expressed in LLCPK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100135((E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)...)
Affinity DataKi:  0.170nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100135((E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)...)
Affinity DataKi:  0.170nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101413(5-[2-bromo-4-(3-carboxy-4-hydroxyphenethyl)pheneth...)
Affinity DataKi:  0.190nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246967(CHEMBL4080228 | US10570121, Example 81)
Affinity DataKi:  0.200nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM435574(US10570121, Example 84 | US10570121, Example 85)
Affinity DataKi:  0.200nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM435614(US10570121, Example 122 | US10570121, Example 123)
Affinity DataKi:  0.200nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50035508(4-Iodo-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM435638(US10570121, Example 144 | US10570121, Example 145)
Affinity DataKi:  0.200nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM435660(US10570121, Example 166 | US10570121, Example 167)
Affinity DataKi:  0.200nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM435689(US10570121, Example 195 | US10570121, Example 196)
Affinity DataKi:  0.200nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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