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TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300226(3-(3-Chlorobenzyl)-5-isobutyl-5-methyl-2-iminohyda...)
Affinity DataKd:  1.23E+5nMAssay Description:Inhibition of BACE1 by fragment-based NMR screening methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM114543(carbamimidothioic acid (4-butoxy-3-chlorophenyl)me...)
Affinity DataKd:  1.50E+4nMAssay Description:Inhibition of BACE1 by fragment-based NMR screening methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50036600(CHEMBL3354262)
Affinity DataEC50:  258nMAssay Description:Inhibition of BACE1-mediated amyloid beta 40 production in HEK293-APPswe/lon cells by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300227((2Z)-3-(3-chlorobenzyl)-2-imino-5,5-dimethylimidaz...)
Affinity DataKd:  2.00E+5nMAssay Description:Inhibition of BACE1 by fragment-based NMR screening methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50036600(CHEMBL3354262)
Affinity DataEC50:  110nMAssay Description:Inhibition of BACE1-mediated amyloid beta 40 production in HEK293-APPswe/lon cells by whole cell assay in presence of P-gp inhibitorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
TargetArginase-1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  5nMAssay Description:Inhibition of human Arginase I in human myeloid-derived suppressor cells using L-arginine as substrate assessed as L-ornithine product formation by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetArginase-1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50008099(CHEMBL1234777)
Affinity DataKd:  50nMAssay Description:Inhibition of human Arginase I assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271628(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271631(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271629(N-((1S,2S)-1-((S)-1-benzyl-5-oxoimidazolidin-4-yl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271705((4R)-N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-y...)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372181(CHEMBL403727)
Affinity DataIC50: 3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271626(N1-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3...)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372186(CHEMBL257645)
Affinity DataIC50: 4nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271630(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271627(N'-[(1S,2S)-2-[(4S)-1-benzyl-5-oxoimidazolidin-4-y...)
Affinity DataIC50: 5nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271862(N1-((1S,2S)-1-((S)-4-(2-methoxybenzyl)-3-oxopipera...)
Affinity DataIC50: 5nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271703(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372198(CHEMBL270359)
Affinity DataIC50: 5nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372187(CHEMBL404078)
Affinity DataIC50: 6nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227337(N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-[(2R,4S)-4-ET...)
Affinity DataIC50: 7nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50317048(N-[(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-2-{(2R...)
Affinity DataIC50: 7nMAssay Description:Inhibition of BACE1 expressed in HEK293 cells expressing human APP assessed as amyloid beta42 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372189(CHEMBL399979)
Affinity DataIC50: 7nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50317050(1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(...)
Affinity DataIC50: 8nMAssay Description:Inhibition of BACE1 expressed in HEK293 cells expressing human APP assessed as amyloid beta42 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227337(N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-[(2R,4S)-4-ET...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50398683(CHEMBL2178147)
Affinity DataIC50: 8nMAssay Description:Inhibition of BACE1 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271810(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271632(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271861(N1-((1S,2S)-1-((S)-4-(cyclopropylmethyl)-3-oxopipe...)
Affinity DataIC50: 10nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271768(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50392835(CHEMBL2151181)
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing APPswe/lon assessed as inhibition of amyloid beta-40 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271811(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372184(CHEMBL402276)
Affinity DataIC50: 12nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50398678(CHEMBL2178152)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50392836(CHEMBL2151141)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing APPswe/lon assessed as inhibition of amyloid beta-40 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50317055(N-((1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((R)...)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1 expressed in HEK293 cells expressing human APP assessed as amyloid beta42 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271860(N1-((1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((S...)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271770(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227345(N'-[(1S,2R)-2-[(2R,4S)-4-benzylpiperidin-2-yl]-1-(...)
Affinity DataIC50: 14nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50317060(N-((1S,2S)-1-((R)-4-(benzylsulfonyl)piperazin-2-yl...)
Affinity DataIC50: 14nMAssay Description:Inhibition of BACE1 expressed in HEK293 cells expressing human APP assessed as amyloid beta42 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227345(N'-[(1S,2R)-2-[(2R,4S)-4-benzylpiperidin-2-yl]-1-(...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM9488(US8541427, 1)
Affinity DataIC50: 14nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human APP Swe/Lon mutations assessed as amyloid beta 40 level after 4 hrs by electrochemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM102946(US8541427, 17)
Affinity DataIC50: 16nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human APP Swe/Lon mutations assessed as amyloid beta 40 level after 4 hrs by electrochemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2017
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271767((4R)-4-benzyl-N-((1S,2S)-1-((S)-4-benzyl-3-oxopipe...)
Affinity DataIC50: 16nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50398693(CHEMBL2178718)
Affinity DataIC50: 16nMAssay Description:Inhibition of BACE1 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM102945(US8541427, 16)
Affinity DataIC50: 17nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human APP Swe/Lon mutations assessed as amyloid beta 40 level after 4 hrs by electrochemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2017
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50398688(CHEMBL2178715)
Affinity DataIC50: 18nMAssay Description:Inhibition of BACE1 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50164512(CHEMBL3800286)
Affinity DataIC50: 18nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human APP Swe/Lon mutations assessed as amyloid beta 40 level after 4 hrs by electrochemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2017
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50398685(CHEMBL2178145)
Affinity DataIC50: 19nMAssay Description:Inhibition of BACE1 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271863(N1-((1S,2S)-1-((R)-4-(2-cyanobenzyl)piperazin-2-yl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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