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Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458550(CHEMBL4209274)
Affinity DataEC50:  188nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458550(CHEMBL4209274)
Affinity DataEC50:  186nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458558(CHEMBL4210782)
Affinity DataEC50:  166nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458557(CHEMBL4215875)
Affinity DataEC50:  41nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458558(CHEMBL4210782)
Affinity DataEC50:  165nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458553(CHEMBL4218672)
Affinity DataEC50:  135nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458557(CHEMBL4215875)
Affinity DataEC50:  41nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458555(CHEMBL4207884)
Affinity DataEC50:  162nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458553(CHEMBL4218672)
Affinity DataEC50:  135nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458555(CHEMBL4207884)
Affinity DataEC50:  162nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458554(CHEMBL4218801)
Affinity DataEC50:  112nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458554(CHEMBL4218801)
Affinity DataEC50:  113nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetVitamin D3 receptor A(Zebrafish)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50496699(CHEMBL3220716)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetVitamin D3 receptor A(Zebrafish)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  5.5nMAssay Description:Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetVitamin D3 receptor A(Zebrafish)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50496700(CHEMBL3220717)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetVitamin D3 receptor A(Zebrafish)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50496700(CHEMBL3220717)
Affinity DataKd:  1.80E+3nMAssay Description:Agonist activity at zebrafish VDR LBD assessed as binding affinity to TAMRA-labeled SRC-1 peptide by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetVitamin D3 receptor A(Zebrafish)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50496701(CHEMBL3220718)
Affinity DataKd:  1.80E+3nMAssay Description:Agonist activity at zebrafish VDR LBD assessed as binding affinity to TAMRA-labeled SRC-1 peptide by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetVitamin D3 receptor A(Zebrafish)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50496701(CHEMBL3220718)
Affinity DataEC50:  0.25nMAssay Description:Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetVitamin D3 receptor A(Zebrafish)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50496699(CHEMBL3220716)
Affinity DataKd:  3.30E+3nMAssay Description:Agonist activity at zebrafish VDR LBD assessed as binding affinity to TAMRA-labeled SRC-1 peptide by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Mouse)
Gwangju Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataEC50:  186nMAssay Description:Inhibition of JAK2 V617F mutant expressed in mouse BaF3 cells cells assessed as reduction in cell viabilityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50564363(CHEMBL4791998)
Affinity DataKd: <0.25nMAssay Description:Binding affinity to human FLT3 ITD mutant in presence of ATP by Lanthascreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50593961(CHEMBL5195819)
Affinity DataKd:  0.0154nMAssay Description:Binding affinity to FLT3 ITD/F691L double mutant (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600976(CHEMBL5200260)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600977(CHEMBL5178074)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600978(CHEMBL5184616)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600979(CHEMBL5188201)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50167161((E)-3-{3-[Cyclohexanecarbonyl-(4'-dimethylamino-bi...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  400nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600980(CHEMBL5173282)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600981(CHEMBL5192609)
Affinity DataEC50:  900nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600982(CHEMBL5174456)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600983(CHEMBL5192926)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600984(CHEMBL5206312)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600985(CHEMBL5187641)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600986(CHEMBL5175359)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600987(CHEMBL5184376)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600988(CHEMBL5170268)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600989(CHEMBL5203101)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600990(CHEMBL5199040)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600991(CHEMBL5189501)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600992(CHEMBL5184244)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600993(CHEMBL5169348)
Affinity DataEC50:  900nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600994(CHEMBL5174900)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600995(CHEMBL5208979)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600996(CHEMBL5208868)
Affinity DataEC50:  900nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600997(CHEMBL5176088)
Affinity DataEC50:  2.60E+3nMAssay Description:Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAndrogen receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50600998(CHEMBL1565119)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human AR expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEstrogen receptor(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human ERalpha expressed in CHO-K1 cells by PathHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
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