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Report error Found 2718 with Last Name = 'levis' and Initial = 'm'
LigandPNGBDBM50300970(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300964(rac-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300972(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM50300983(7-(6-methoxypyridin-3-yl)-3-(2-(4-methylpiperazin-...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300976(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.0750nMAssay Description:Binding affinity to PDGFRBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50300977(7-(6-methoxypyridin-3-yl)-3-(2-oxo-2-(pyrrolidin-1...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300989((S)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300991((R)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300962(3-(2-ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300978(3-(2-(4-hydroxypiperidin-1-yl)-2-oxoethylamino)-7-...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300985(3-(2-(4-ethylpiperazin-1-yl)-2-oxoethylamino)-7-(6...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300963(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-((t...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300948((R)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300980(7-(6-methoxypyridin-3-yl)-3-(2-morpholino-2-oxoeth...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300961(3-(2-ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50308556(3-(4-(3-hydroxypropyl)piperazin-1-yl)-1-(2-propoxy...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50308563(3-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)-1-(...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50308558(3-(4-ethylpiperazin-1-yl)-1-(2-propoxyethyl)-7-(6-...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50308564((R)-3-(4-(2-hydroxypropyl)piperazin-1-yl)-1-(2-iso...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50300950((S)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300951((R)-3-(1-hydroxybutan-2-ylamino)-7-(6-methoxypyrid...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300957(3-(2-aminoethylamino)-7-(6-methoxypyridin-3-yl)-1-...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300957(3-(2-aminoethylamino)-7-(6-methoxypyridin-3-yl)-1-...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50300987(3-(3-hydroxypropylamino)-7-(6-methoxypyridin-3-yl)...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300971(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50297794(2-(4-(cyclohexylmethyl)-6-(6-methoxypyridin-3-yl)-...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50308561((+/-)-3-(4-((2R,3R)-3-hydroxybutan-2-yl)piperazin-...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50297796(4-(cyclohexylmethyl)-6-(2-methoxypyrimidin-5-yl)-2...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297795(4-(cyclohexylmethyl)-6-(6-methoxypyridin-3-yl)-2-(...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50308553((S)-3-(4-(2-hydroxypropyl)piperazin-1-yl)-1-(2-iso...)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50300982(7-(6-methoxypyridin-3-yl)-3-(2-(4-methylpiperazin-...)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300952(3-(trans-4-hydroxycyclohexylamino)-7-(6-methoxypyr...)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50308562((+/-)-3-(4-((2S,3R)-3-hydroxybutan-2-yl)piperazin-...)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50296257(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50296257(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM50300988((S)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50300969(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.370nMAssay Description:Binding affinity to KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50300984(3-(2-(4-ethylpiperazin-1-yl)-2-oxoethylamino)-7-(6...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  0.390nMAssay Description:Binding affinity to PHKG1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50297797(4-(cyclohexylmethyl)-6-(6-methoxypyridin-3-yl)-2-(...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50300975(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.470nMAssay Description:Binding affinity to FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.470nMAssay Description:Binding affinity to FLT3 catalytic domain by KinomeScan kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 19(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  0.520nMAssay Description:Binding affinity to YSK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
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