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TargetNociceptin receptor(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  0.230nMAssay Description:Agonist activity at human nociceptin receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2017
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50173126(CHEMBL3809510)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human nociceptin receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2017
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50173127(CHEMBL3808415)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human nociceptin receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2017
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50173128(CHEMBL3808398)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human nociceptin receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2017
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50173129(CHEMBL3810104)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human nociceptin receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2017
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50173130(CHEMBL3808523)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human nociceptin receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2017
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50001468(deltorphin C | CHEMBL317956 | H-Tyr-D-Ala-Phe-Asp-...)
Affinity DataIC50: 0.110nMAssay Description:Inhibitory activity against Mouse vas deferens smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50043717({(4S,7R,10S,13R)-13-[(S)-2-Amino-3-(4-hydroxy-phen...)
Affinity DataIC50: 0.230nMAssay Description:In vitro inhibition of electrically induced smooth muscle contractions of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50280456({(4S,7R,10S,13R)-13-[(S)-2-Amino-3-(4-hydroxy-phen...)
Affinity DataIC50: 0.230nMAssay Description:Inhibitory activity against Mouse vas deferens smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50070386(CHEMBL3408737)
Affinity DataIC50: 0.240nMAssay Description:Activation of DOR in mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50070386(CHEMBL3408737)
Affinity DataIC50: 0.240nMAssay Description:Agonist activity at delta opioid receptor in Swiss Webster albino mouse vas deferans assessed as inhibition of electrically-induced longitudinal musc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2017
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50043712({(4S,7R,10S,13R)-13-[(S)-2-Amino-3-(4-hydroxy-phen...)
Affinity DataIC50: 0.25nMAssay Description:In vitro inhibition of electrically induced smooth muscle contractions of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50009180(3-(2-{2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataIC50: 0.280nMAssay Description:In vitro inhibition of electrically induced smooth muscle contractions of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50346330((R)-N-((S)-2-(2-amino-2-oxoethyl)-3-oxo-2,3,4,5-te...)
Affinity DataIC50: 0.320nMAssay Description:Activation of MOR in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50070379(CHEMBL3408521)
Affinity DataIC50: 0.330nMAssay Description:Activation of DOR in mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50010488(CHEMBL3264361)
Affinity DataIC50: 0.350nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50346330((R)-N-((S)-2-(2-amino-2-oxoethyl)-3-oxo-2,3,4,5-te...)
Affinity DataIC50: 0.420nMAssay Description:Activation of DOR in mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
LigandPNGBDBM50226933(Naltrexonazine)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
LigandPNGBDBM50226933(Naltrexonazine)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50009180(3-(2-{2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of [3H][p-Cl-Phe-]DPDE binding to rat brain homogenate delta-opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50226933(Naltrexonazine)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50001468(deltorphin C | CHEMBL317956 | H-Tyr-D-Ala-Phe-Asp-...)
Affinity DataIC50: 0.600nMAssay Description:Binding affinity against delta receptor with [3H][p-Cl-Phe4]-DPDPEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50010486(CHEMBL3264359)
Affinity DataIC50: 0.660nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50001468(deltorphin C | CHEMBL317956 | H-Tyr-D-Ala-Phe-Asp-...)
Affinity DataIC50: 0.670nMAssay Description:In vitro inhibition of electrically induced smooth muscle contractions of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50001468(deltorphin C | CHEMBL317956 | H-Tyr-D-Ala-Phe-Asp-...)
Affinity DataIC50: 0.670nMAssay Description:In vitro inhibition of electrically induced smooth muscle contractions of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50001468(deltorphin C | CHEMBL317956 | H-Tyr-D-Ala-Phe-Asp-...)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of [3H][p-Cl-Phe-]DPDE binding to rat brain homogenate delta-opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50001468(deltorphin C | CHEMBL317956 | H-Tyr-D-Ala-Phe-Asp-...)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of [3H][p-Cl-Phe-]DPDE binding to rat brain homogenate delta-opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50081526((S)-2-Amino-N-{(R)-1-[({(S)-2-[N'-((R)-2-amino-3-p...)
Affinity DataIC50: 0.740nMAssay Description:In vitro binding affinity towards mu opioid receptors was determined using [3H][p-Cl-Phe]- 4] DPDPE or [3H]deltorphin IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Mossakowski Medical Research Centre Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50081529((S)-2-Amino-N-{(R)-1-[({(S)-2-[N'-((S)-2-amino-3-p...)
Affinity DataIC50: 0.740nMAssay Description:Displacement of [3H]DAMGO from MOR in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50070386(CHEMBL3408737)
Affinity DataIC50: 0.800nMAssay Description:Activation of MOR in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50070386(CHEMBL3408737)
Affinity DataIC50: 0.800nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-induced contraction by isometric force transducer a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2017
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50043717({(4S,7R,10S,13R)-13-[(S)-2-Amino-3-(4-hydroxy-phen...)
Affinity DataIC50: 0.870nMAssay Description:Inhibition of [3H][p-Cl-Phe-]DPDE binding to rat brain homogenate delta-opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50280456({(4S,7R,10S,13R)-13-[(S)-2-Amino-3-(4-hydroxy-phen...)
Affinity DataIC50: 0.870nMAssay Description:Binding affinity against delta receptor with [3H][p-Cl-Phe4]-DPDPEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetMu-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50081529((S)-2-Amino-N-{(R)-1-[({(S)-2-[N'-((S)-2-amino-3-p...)
Affinity DataIC50: 0.880nMAssay Description:In vitro binding affinity towards mu opioid receptors was determined using [3H][p-Cl-Phe]- 4] DPDPE or [3H]deltorphin IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50070379(CHEMBL3408521)
Affinity DataIC50: 0.960nMAssay Description:Activation of MOR in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50070378(CHEMBL3408520)
Affinity DataIC50: 1.10nMAssay Description:Activation of DOR in mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Mossakowski Medical Research Centre Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50081527((S)-2-Amino-N-{(R)-1-[({(S)-2-[N'-((S)-2-amino-hex...)
Affinity DataIC50: 1.30nMAssay Description:In vitro binding affinity towards mu opioid receptors was determined using [3H][p-Cl-Phe]- 4] DPDPE or [3H]deltorphin IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21014((2S)-2-amino-N-[(1R)-1-[({[(1S)-1-{N'-[(2S)-2-{2-[...)
Affinity DataIC50: 1.40nMAssay Description:In vitro binding affinity towards mu opioid receptors was determined using [3H][p-Cl-Phe]- 4] DPDPE or [3H]deltorphin IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50010483(CHEMBL2181202)
Affinity DataIC50: 1.40nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50010483(CHEMBL2181202)
Affinity DataIC50: 1.40nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50173128(CHEMBL3808398)
Affinity DataIC50: 1.40nMAssay Description:Agonist activity at delta opioid receptor in Swiss Webster albino mouse vas deferans assessed as inhibition of electrically-induced longitudinal musc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Mossakowski Medical Research Centre Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50208162(CHEMBL3904919)
Affinity DataIC50: 1.40nMAssay Description:Displacement of [3H]DAMGO from MOR in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50010487(CHEMBL3264360)
Affinity DataIC50: 1.5nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50081528((S)-2-Amino-N-((R)-1-{[((S)-2-{N'-[(R)-2-amino-3-(...)
Affinity DataIC50: 1.60nMAssay Description:In vitro binding affinity towards mu opioid receptors was determined using [3H][p-Cl-Phe]- 4] DPDPE or [3H]deltorphin IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50069559(Biphalin Analogue | CHEMBL2371057)
Affinity DataIC50: 1.70nMAssay Description:Compound was tested for binding affinity towards mu opioid receptor in guinea pig brain homogenates using [3H]CTOP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50070377(CHEMBL3408519)
Affinity DataIC50: 1.90nMAssay Description:Activation of MOR in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50070377(CHEMBL3408519)
Affinity DataIC50: 1.90nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50081525((S)-2-Amino-N-((R)-1-{[((S)-2-{N'-[(R)-2-amino-3-(...)
Affinity DataIC50: 2nMAssay Description:In vitro binding affinity towards mu opioid receptors was determined using [3H][p-Cl-Phe]- 4] DPDPE or [3H]deltorphin IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50010486(CHEMBL3264359)
Affinity DataIC50: 2nMAssay Description:Agonist activity at delta opioid receptor in mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
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