Report error Found 3740 with Last Name = 'luo' and Initial = 'c'
Affinity DataKi: 0.160nM ΔG°: -58.2kJ/molepH: 7.0 T: 37°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 0.5nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Displacement of 5-FAM labelled tracer from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nM ΔG°: -50.9kJ/molepH: 8.2 T: 22°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Displacement of 5-FAM labelled tracer from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Displacement of 5-FAM labelled tracer from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Affinity DataKi: 1.75nM ΔG°: -49.5kJ/molepH: 7.4 T: 22°CAssay Description:The inhibitors reported in this study bind to CHK1 according to a general mechanism illustrated in Scheme 1 where E, S, and I stand for enzyme, subst...More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Affinity DataKi: 2.60nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 2(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 3.10nMAssay Description:Binding affinity to human recombinant BRD2 BD2 (349 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
Affinity DataKi: 5nM ΔG°: -46.9kJ/molepH: 8.2 T: 22°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
Affinity DataKi: 5.14nM ΔG°: -46.5kJ/molepH: 8.0 T: 20°CAssay Description:Surface plasmon resonance (SPR) biosensor binding studies were conducted using a Biacore 3000 instrument (GE Healtchare).More data for this Ligand-Target Pair
Affinity DataKi: 5.20nM ΔG°: -46.8kJ/molepH: 8.2 T: 22°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 5.30nMAssay Description:Binding affinity to human recombinant BRD3 BD2 (306 to 417 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.60nM ΔG°: -46.6kJ/molepH: 8.2 T: 22°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 7.30nMAssay Description:Binding affinity to human recombinant BRD4 BD2 (333 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 8nM ΔG°: -45.7kJ/molepH: 7.4 T: 22°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibitory concentration against Human Serine Protease Urokinase Plasminogen ActivatorMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:The compound was tested for inhibition of human urokinase type plasminogen activator (microPa)More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of urokinase-type plasminogen activatorMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 8.20nMAssay Description:Binding affinity to human recombinant BRD3 BD2 (306 to 417 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 8.70nMAssay Description:Binding affinity to human recombinant BRD3 BD1 (24 to 144 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 2(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 8.90nMAssay Description:Binding affinity to human recombinant BRD2 BD2 (349 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 9nM ΔG°: -45.5kJ/molepH: 7.4 T: 22°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:The compound was tested for inhibition of human urokinase type plasminogen activator (microPa)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 2(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 9.10nMAssay Description:Binding affinity to human recombinant BRD2 BD2 (349 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 9.90nMAssay Description:Binding affinity to human recombinant BRD4 BD2 (333 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 2(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Binding affinity to human recombinant BRD2 BD2 (349 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
Affinity DataKi: 11nM ΔG°: -45.0kJ/molepH: 7.4 T: 22°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Affinity DataKi: 11nM ΔG°: -45.0kJ/molepH: 5.0 T: 22°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of urokinase-type plasminogen activatorMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Binding affinity to human recombinant BRD3 BD2 (306 to 417 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Binding affinity to human recombinant BRD3 BD2 (306 to 417 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 11nM ΔG°: -45.0kJ/molepH: 7.45 T: 22°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Binding affinity to human recombinant BRD4 BD2 (333 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Binding affinity to human recombinant BRD4 BD1 (44 to 168 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
