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LigandPNGBDBM693394(1-(4-(methylsulfonyl)phenyl)-N-(2,3,6- trifluoro-4...)
Affinity DataIC50: 0.140nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693353(N-(4-((3-(2-(((1r,4r)-4- (dimethylamino)cyclohexyl...)
Affinity DataIC50: 0.150nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693367(1-p-tolyl-N-(2,3,6-trifluoro-4-((3-(2- (((3S,5S)-5...)
Affinity DataIC50: 0.150nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693424(US12071425, Compound 344 | US12071425, Compound 34...)
Affinity DataIC50: 0.160nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693424(US12071425, Compound 344 | US12071425, Compound 34...)
Affinity DataIC50: 0.170nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693415(US12071425, Compound 334 | US12071425, Compound 33...)
Affinity DataIC50: 0.190nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693437(1-(2-fluorophenyl)-N-[2,3,6-trifluoro-4- [[3-[2-[[...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693469((*S)-1-phenyl-N-(2,3,6-trifluoro-4-((3- (2-(((3S,5...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693436(1-(4-chlorophenyl)-N-[2,3,6-trifluroo-4- [[3-[2-[[...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693438(1-(2-pyridyl)-N-[2,3,6-trifluoro-4-[[3-[2- [[(3S,5...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693467(1-(3-methoxyphenyl)-N-(2,3,6-trifluoro- 4-((3-(2-(...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693434(1-(2-chlorophenyl)-N-[2,3,6-trifluoro-4- [[3-[2-[[...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693445(1-(2,6-difluorophenyl)-N-[2,3,6-trifluoro- 4-[[3-[...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693444(1-(4-chloro-2-cyano-phenyl)-N-[2,3,6- trifluoro-4-...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693454(1-(4-fluorophenyl)-N-(2,3,6-trifluoro-4- ((3-(2-((...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693449(1-(2-chloro-6-fluorophenyl)-N-(2,3,6- trifluoro-4-...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693448(1-(3-chloro-4-fluoro-phenyl)-N-[2,3,6- trifluoro-4...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693450(N-(2,3,6-trifluoro-4-((3-(2-(((3S,5S)-5- fluoropip...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693424(US12071425, Compound 344 | US12071425, Compound 34...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM50059194(CHEMBL3393337)
Affinity DataKi:  0.200nMAssay Description:Inhibition of DLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandPNGBDBM693456(N-(2,3,6-trifluoro-4-((3-(2-(((3S,5S)-5- fluoropip...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693458(1-(bicyclo[2.2.1]heptan-1-yl)-N-(2,3,6- trifluoro-...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693387(N-(2,3-difluoro-4-((3-(2-(((3S,5S)-5- fluoro-5-met...)
Affinity DataIC50: 0.210nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693356(1-(2-fluorophenyl)-N-(2,3,6-trifluoro-4- ((3-(2-((...)
Affinity DataIC50: 0.230nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693386(1-(4-methoxyphenyl)-N-(2,3,6-trifluoro- 4-((3-(2-(...)
Affinity DataIC50: 0.230nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693397(1-(4-cyclopropylphenyl)-N-(2,3,6- trifluoro-4-((3-...)
Affinity DataIC50: 0.230nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693362(N-(2,3-difluoro-4-((3-(2-(((3S,5S)-5- fluoro-5-met...)
Affinity DataIC50: 0.230nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693419(N-(4-((3-(2-((5-(1,1- difluoroethyl)piperidin-3- y...)
Affinity DataIC50: 0.240nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693395(N-(2,3-difluoro-4-((3-(2-(((3S,5S)-5- fluoropiperi...)
Affinity DataIC50: 0.240nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693343(1-phenyl-N-(2,3,6-trifluoro-4-((3-(2- (((3S,5R)-5-...)
Affinity DataIC50: 0.25nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693406(N-(4-((3-(2-((5-cyclopropylpiperidin-3- yl)amino)p...)
Affinity DataIC50: 0.260nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693365(1-(2,6-difluorophenyl)-N-(2,3,6-trifluoro- 4-((3-(...)
Affinity DataIC50: 0.270nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693373(1-(3-methoxyphenyl)-N-(2,3,6-trifluoro- 4-((3-(2-(...)
Affinity DataIC50: 0.280nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693379(N-(2,3-difluoro-4-((3-(2-(((3S,5S)-5- fluoro-5-met...)
Affinity DataIC50: 0.280nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693393(N-(2,5-difluoro-4-((3-(2-(((3S,5S)-5- fluoro-5-met...)
Affinity DataIC50: 0.290nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693453(1-(4-(difluoromethyl)phenyl)-N-(2,3,6- trifluoro-4...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693468(1-o-tolyl-N-(2,3,6-trifluoro-4-((3-(2- (((3S,5S)-5...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693471(N-(2,3,6-trifluoro-4-((3-(2-(((3S,5S)-5- fluoropip...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693455(N-(2,3,6-trifluoro-4-((3-(2-(((3S,5S)-5- fluoropip...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693399(US12071425, Compound 319 | 1-phenyl-N-(2,3,6-trifl...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693435(1-(3-chlorophenyl)-N-[2,3,6-trifluoro-4- [[3-[2-[[...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693466(1-(2-fluoro-4-methylphenyl)-N-(2,3,6- trifluoro-4-...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693461(1-(4-cyanophenyl)-N-(2,3-difluoro-4-((3- (2-(((S)-...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693446(1-(4-chloro-2-fluoro-phenyl)-N-[2,3,6- trifluoro-4...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693441(1-(4-pyridyl)-N-[2,3,6-trifluoro-4-[[3-[2- [[(3S,5...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693440(1-(2-cyanophenyl)-N-[2,3,6-trifluoro-4- [[3-[2-[[(...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693443(3-fluoro-4-[[2,3,6-trifluoro-4-[[3-[2- [[(3S,5S)-5...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693388(N-(4-((3-(2-((4-(dimethylamino)-3- fluorocyclohexy...)
Affinity DataIC50: 0.310nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693363(N-(2,3-difluoro-4-((3-(2-(((3S,5S)-5- fluoropiperi...)
Affinity DataIC50: 0.310nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693392(N-(4-((3-(2-(((1r,4r)-4- (dimethylamino)cyclohexyl...)
Affinity DataIC50: 0.320nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

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