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TargetLysine-specific demethylase 5A [1-588](Human)
Emory University

LigandPNGBDBM191596(6-isopropyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5...)
Affinity DataKd:  27nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A [1-588](Human)
Emory University

LigandPNGBDBM191597(3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...)
Affinity DataKd:  46nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A [1-588](Human)
Emory University

LigandPNGBDBM191598(KDOAM-20 | KDM5-C49 | 2-(((2-((2-(dimethylamino)et...)
Affinity DataKd:  52nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A [1-588](Human)
Emory University

LigandPNGBDBM191599(KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(...)
Affinity DataKd: >1.00E+4nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A [1-588](Human)
Emory University

LigandPNGBDBM191600(US9714230, 89 | 2-(5-((4-chloro-2-methylbenzyl)oxy...)
Affinity DataKd:  60nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A [1-588](Human)
Emory University

LigandPNGBDBM191601(3-(2-(4-chlorophenyl)acetamido)isonicotinic acid (...)
Affinity DataKd:  360nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A [1-588](Human)
Emory University

LigandPNGBDBM191602(3-((1-methyl-1Hpyrrolo[2,3-b]pyridin-3-yl)amino)is...)
Affinity DataKd:  450nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A [1-588](Human)
Emory University

LigandPNGBDBM50396019(CHEMBL2169917 | 4'-(phenethylcarbamoyl)-[2,2&#...)
Affinity DataKd:  1.20E+3nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A [1-588](Human)
Emory University

LigandPNGBDBM191603(methyl 4'-(phenethylcarbamoyl)-[2,2'-bipyr...)
Affinity DataKd:  7.00E+3nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A [1-588](Human)
Emory University

LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataKd: >4.00E+4nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B [1-604](Human)
Emory University

LigandPNGBDBM191596(6-isopropyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5...)
Affinity DataKd:  20nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B [1-604](Human)
Emory University

LigandPNGBDBM191597(3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...)
Affinity DataKd:  55nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B [1-604](Human)
Emory University

LigandPNGBDBM191598(KDOAM-20 | KDM5-C49 | 2-(((2-((2-(dimethylamino)et...)
Affinity DataKd:  80nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B [1-604](Human)
Emory University

LigandPNGBDBM191599(KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(...)
Affinity DataKd: >8.00E+3nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B [1-604](Human)
Emory University

LigandPNGBDBM191600(US9714230, 89 | 2-(5-((4-chloro-2-methylbenzyl)oxy...)
Affinity DataKd:  70nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B [1-604](Human)
Emory University

LigandPNGBDBM191601(3-(2-(4-chlorophenyl)acetamido)isonicotinic acid (...)
Affinity DataKd:  430nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B [1-604](Human)
Emory University

LigandPNGBDBM191602(3-((1-methyl-1Hpyrrolo[2,3-b]pyridin-3-yl)amino)is...)
Affinity DataKd:  330nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B [1-604](Human)
Emory University

LigandPNGBDBM50396019(CHEMBL2169917 | 4'-(phenethylcarbamoyl)-[2,2&#...)
Affinity DataKd:  1.60E+3nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B [1-604](Human)
Emory University

LigandPNGBDBM191603(methyl 4'-(phenethylcarbamoyl)-[2,2'-bipyr...)
Affinity DataKd:  8.00E+3nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B [1-604](Human)
Emory University

LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataKd: >3.00E+4nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2016
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50245000(CHEMBL4096760)
Affinity DataKd:  60nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50245001(CHEMBL4059617)
Affinity DataKd:  470nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50245002(CHEMBL4081571)
Affinity DataKd:  150nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50245003(CHEMBL4066179)
Affinity DataKd:  250nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM281089(US10022354, Example 29)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM281088(US10022354, Example 28)
Affinity DataKd: >1.20E+4nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM320423(US10174026, Example 88 | 2-[(2-chlorophenyl)-propo...)
Affinity DataKd:  530nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50245037(CHEMBL4062359)
Affinity DataKd:  220nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50245005(CHEMBL4070992)
Affinity DataKd:  210nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50245006(CHEMBL4077310)
Affinity DataKd:  410nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50245004(CHEMBL4090351)
Affinity DataKd:  180nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250674(CHEMBL4076973 | US10961200, Compound 53 | US112479...)
Affinity DataKd:  370nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250677(CHEMBL4100845 | US10961200, Compound 52 | US112479...)
Affinity DataKd:  0.330nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250656(CHEMBL4081890 | US11247971, Cmpd ID 276)
Affinity DataEC50:  170nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250685(CHEMBL1479261 | US10961200, Compound 62 | US112479...)
Affinity DataEC50: >1.00E+5nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250648(CHEMBL4080497 | US10961200, Compound 20 | US112479...)
Affinity DataEC50:  2.56E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM86137(LDHA Inhibitor, 33)
Affinity DataEC50:  1.60E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50103568(CHEMBL3335794)
Affinity DataKd:  59nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250652(CHEMBL4101800 | US10961200, Compound 42 | US112479...)
Affinity DataEC50: >1.00E+5nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250656(CHEMBL4081890 | US11247971, Cmpd ID 276)
Affinity DataKd:  0.110nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250674(CHEMBL4076973 | US10961200, Compound 53 | US112479...)
Affinity DataEC50:  3.53E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250677(CHEMBL4100845 | US10961200, Compound 52 | US112479...)
Affinity DataEC50:  250nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250655(CHEMBL4059985 | US10961200, Compound 189 | US11247...)
Affinity DataEC50:  70nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50103568(CHEMBL3335794)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to human His-tagged LDHA in absence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM197160(GNE-140 (6))
Affinity DataEC50:  1.26E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50103568(CHEMBL3335794)
Affinity DataEC50:  8.18E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456222(CHEMBL4206272)
Affinity DataEC50:  5.59E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature at 70 degC after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456223(CHEMBL4206892)
Affinity DataEC50:  2.72E+3nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of 100 nM paclitaxel-mediated cytotoxicity after 4 days by CellTiter-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456222(CHEMBL4206272)
Affinity DataEC50:  2.00E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
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