Compile Data Set for Download or QSAR
Report error Found 4451 with Last Name = 'marsh' and Initial = 'kc'
LigandPNGBDBM20431(1-[(4-bromophenyl)methyl]-3-1H-indol-6-ylurea | he...)
Affinity DataEC50:  3.01E+3nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193315((E)-1-(4-chlorophenyl)-3-(3',4',5',6'-tetrahydro-2...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193341(CHEMBL385230 | CHEMBL214954 | (E)-1-(2-chloropheny...)
Affinity DataEC50:  25nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50249655(5-(4-Chlorophenyl)-2-methyl-3-(morpholine-1-carbon...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulator activity at alpha7 nAChR in human IMR32 cells assessed as stimulation of agonist-induced intracellular calcium level by FLIPR as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315779((S)-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benz...)
Affinity DataEC50:  4nMAssay Description:Inhibition of PARP1 in human C41 cells by FITC-conjugated DAPI stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193312(CHEMBL214314 | CHEMBL385350 | (E)-1-phenyl-3-(4-py...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50200029(A-425444 | 6-(4-((1H-benzo[d]imidazol-2-yl)methyl)...)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50200074(N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridi...)
Affinity DataEC50:  68nMAssay Description:Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50200085(3,5-dichloro-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50200040(N-(2,6-dimethylphenyl)-2-(1-oxy-3',4',5',6'-tetrah...)
Affinity DataEC50:  346nMAssay Description:Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193331((E)-1-(3,4-dichlorophenyl)-3-(4-pyridin-2-ylpipera...)
Affinity DataEC50:  542nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193376((E)-1-(4-fluorophenyl)-3-(4-pyridin-2-ylpiperazin-...)
Affinity DataEC50:  31nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193347((Z)-3-(4-pyridin-2-ylpiperazin-1-yl)-1-(o-tolyl)pr...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315788(2-(4-(1-Isopropyl-piperidin-3-yl)phenyl)-1H-benzim...)
Affinity DataEC50:  26nMAssay Description:Inhibition of PARP1 in human C41 cells by FITC-conjugated DAPI stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193316([1-phenyl-3-(4-pyridin-2-ylpiperazin-1-yl)propylid...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193391((Z)-1-(3-chloro-4-fluorophenyl)-3-(4-pyridin-2-ylp...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20414(3-isoquinolin-8-yl-1-{3-[(trifluoromethyl)sulfanyl...)
Affinity DataEC50:  1.10E+3nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20433(1-[(4-bromophenyl)methyl]-3-1H-indazol-4-ylurea | ...)
Affinity DataEC50:  13nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193296((Z)-1-(3-fluorophenyl)-3-(4-pyridin-2-ylpiperazin-...)
Affinity DataEC50:  60.2nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM15073((2R)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl]py...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2007
Entry Details Article
PubMed
LigandPNGBDBM20409(3-1H-indazol-4-yl-1-[(1R)-1-(naphthalen-2-yl)ethyl...)
Affinity DataEC50:  123nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50200027(6-chloro-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'...)
Affinity DataEC50:  1.29E+3nMAssay Description:Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50200047(N-(2-trifluoromethyl-4-fluorophenyl)-2-(1-oxy-3',4...)
Affinity DataEC50:  473nMAssay Description:Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50251695(2-(2-(piperidin-1-yl)propan-2-yl)-1H-benzo[d]imida...)
Affinity DataEC50:  3.10nMAssay Description:Inhibition of PARP1 in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315787(2-(4-(1-Isopropyl-piperidin-2-yl)phenyl)-1H-benzim...)
Affinity DataEC50:  8nMAssay Description:Inhibition of PARP1 in human C41 cells by FITC-conjugated DAPI stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50484622(CHEMBL1939313)
Affinity DataEC50: >1.00E+5nMAssay Description:Partial agonist activity at human nAChR alpha4beta2 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193300(CHEMBL378427 | CHEMBL209472 | (E)-1-(4-fluoropheny...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193374((Z)-1-(4-chlorophenyl)-3-(4-pyridin-2-ylpiperazin-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193346(CHEMBL214440 | CHEMBL215849 | (E)-3-(4-pyridin-2-y...)
Affinity DataEC50:  4.20nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193312(CHEMBL214314 | CHEMBL385350 | (E)-1-phenyl-3-(4-py...)
Affinity DataEC50:  4.40nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50200046(pyridine-2-carboxylic acid (1-oxy-3',4',5',6'-tetr...)
Affinity DataEC50:  3.15E+3nMAssay Description:Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20404(3-1H-indazol-4-yl-1-[(1S)-1-[4-(trifluoromethyl)ph...)
Affinity DataEC50:  248nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193334((Z)-1-(4-fluorophenyl)-3-(4-pyridin-2-ylpiperazin-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193355(CHEMBL211972 | CHEMBL212804 | (E)-1-phenyl-3-(4-py...)
Affinity DataEC50:  69nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50200058(N-(3-trifluoromethoxyphenyl)-2-(1-oxy-3',4',5',6'-...)
Affinity DataEC50:  135nMAssay Description:Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193387((E)-3-[4-(3-methylpyridin-2-yl)piperazin-1-yl]-1-p...)
Affinity DataEC50:  253nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193340((E)-1-(4-chlorophenyl)-3-(4-pyridin-2-ylpiperazin-...)
Affinity DataEC50:  475nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20351(3-{[4-(azepan-1-yl)-3-fluorophenyl]methyl}-1-isoqu...)
Affinity DataEC50:  2.80nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
LigandPNGBDBM20416(3-isoquinolin-5-yl-1-{[3-(trifluoromethyl)phenyl]m...)
Affinity DataEC50:  51nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50145075(2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benz...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50484592(CHEMBL1939309)
Affinity DataEC50: >3.00E+4nMAssay Description:Partial agonist activity at human nAChR alpha4beta2 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193365((Z)-1-(4-Fluorophenyl)-2-(4-pyridin-2-yl)ethanone ...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193372((E)-1-(3-chloro-4-fluorophenyl)-3-(4-pyridin-2-ylp...)
Affinity DataEC50:  148nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20417(CHEMBL103063 | 3-isoquinolin-5-yl-1-{2-[4-(trifluo...)
Affinity DataEC50:  19nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193318((E)-1-(4-chloro-3-methylphenyl)-3-(4-pyridin-2-ylp...)
Affinity DataEC50:  135nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20369(1-({4-[(1R,5S)-8-azabicyclo[3.2.1]octan-8-yl]-2,3-...)
Affinity DataEC50:  25.5nMAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193380((E)-1-phenyl-3-(4-pyrimidin-2-ylpiperazin-1-yl)pro...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193322(1-pyridin-3-yl-3-(4-pyridin-2-ylpiperazin-1-yl)pro...)
Affinity DataEC50:  33.3nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193324((E)-1-phenyl-3-(4-phenylpiperazin-1-yl)propan-1-on...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50200057(N-(3,5-dimethylphenyl)-2-(1-oxy-3',4',5',6'-tetrah...)
Affinity DataEC50:  52nMAssay Description:Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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