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TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047485(CHEMBL3319217)
Affinity DataIC50: 0.0780nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047481(CHEMBL3319221)
Affinity DataIC50: 0.150nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50508937(CHEMBL4448046)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to Mcl1 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047429(CHEMBL3319398)
Affinity DataIC50: 0.240nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataKd:  0.280nMAssay Description:Binding affinity to human PAK1 (S149 to H545 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047480(CHEMBL3319222)
Affinity DataIC50: 0.290nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047431(CHEMBL3319397)
Affinity DataIC50: 0.310nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047482(CHEMBL3319220)
Affinity DataIC50: 0.310nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataKd:  0.320nMAssay Description:Binding affinity to human PAK2 (P151 to R525 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047483(CHEMBL3319219)
Affinity DataIC50: 0.330nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201648(CHEMBL3950903)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047688(CHEMBL3319407)
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047426(CHEMBL3319400)
Affinity DataIC50: 0.430nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201651(CHEMBL3896232)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047474(CHEMBL3319228)
Affinity DataIC50: 0.480nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385398(CHEMBL2036730)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of rat DGAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385398(CHEMBL2036730)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of DGAT1-mediated triacylglycerol synthesis in human HuTu80 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047475(CHEMBL3319227)
Affinity DataIC50: 0.530nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047428(CHEMBL3319399)
Affinity DataIC50: 0.570nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201654(CHEMBL3964858)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385398(CHEMBL2036730)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047432(CHEMBL3319396)
Affinity DataIC50: 0.620nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047478(CHEMBL3319225)
Affinity DataIC50: 0.670nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047479(CHEMBL3319224)
Affinity DataIC50: 0.690nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50508937(CHEMBL4448046)
Affinity DataKi:  0.700nMAssay Description:Inhibition of Mcl1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047418(CHEMBL3319223)
Affinity DataIC50: 0.770nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563635(CHEMBL4777640)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of 6His/thrombin cleavage site-fused Avi-tagged dephosphorylated MER (unknown origin) (R528 to M999 residues) using Axltide (CKKSRGDYMTMQJ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047687(CHEMBL3319406)
Affinity DataIC50: 0.920nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant human PAK1 (150-end residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
LigandPNGBDBM50636819(CHEMBL5561612)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant wildtype human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) expressed in Sf21 insect cells using Po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50636816(CHEMBL5567575)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant wildtype human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) expressed in Sf21 insect cells using Po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM368374(US10227342, Example 10)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant wildtype human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) expressed in Sf21 insect cells using Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385398(CHEMBL2036730)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047434(CHEMBL3319229)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047416(CHEMBL3319215)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201649(CHEMBL3914181)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573136(CHEMBL4875486)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of 6His/thrombin cleavage site-fused Avi-tagged dephosphorylated MER (unknown origin) (R528 to M999 residues) using Axltide (CKKSRGDYMTMQJ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50636815(CHEMBL5558799)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant wildtype human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) expressed in Sf21 insect cells using Po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50636815(CHEMBL5558799)
Affinity DataIC50: 2nMAssay Description:Inhibition of 6His-tagged TEV-GS fused EGFR D770_N771insNPG mutant (G696 to G1210 reisudes) (unknown origin) expressed in Sf21 cells using Poly(Glu,T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50392216(CHEMBL2153191 | US8673938, 7)
Affinity DataIC50: 2nMAssay Description:Inhibition of 11betaHSD1 in human isolated adipocytes using [3H]cortisone as substrate after 6 hrs by flow scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Mer(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573135(CHEMBL4873217)
Affinity DataIC50: 2nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201642(CHEMBL3942173)
Affinity DataIC50: 2nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
LigandPNGBDBM50636820(CHEMBL5559367)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant wildtype human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) expressed in Sf21 insect cells using Po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201655(CHEMBL3924245)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573128(CHEMBL4865752)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201650(CHEMBL3933198)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of Bcl6 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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