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TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM50323697(thiamet-G | (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(H...)
Affinity DataEC50:  13nMT: 2°CAssay Description:The ELISA portion of the assay is performed in a black Maxisorp 96-well plate that is coated overnight at 4° C. with 100 uL/well of the cell lysa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2018
Entry Details
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TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM70885(US9695197, 2)
Affinity DataEC50:  139nMT: 2°CAssay Description:The ELISA portion of the assay is performed in a black Maxisorp 96-well plate that is coated overnight at 4° C. with 100 uL/well of the cell lysa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2018
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM77047(US9695197, 3)
Affinity DataEC50:  29nMT: 2°CAssay Description:The ELISA portion of the assay is performed in a black Maxisorp 96-well plate that is coated overnight at 4° C. with 100 uL/well of the cell lysa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2018
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM77064(US9695197, 4)
Affinity DataEC50:  3nMT: 2°CAssay Description:The ELISA portion of the assay is performed in a black Maxisorp 96-well plate that is coated overnight at 4° C. with 100 uL/well of the cell lysa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2018
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM77863(US9695197, 5)
Affinity DataEC50:  349nMT: 2°CAssay Description:The ELISA portion of the assay is performed in a black Maxisorp 96-well plate that is coated overnight at 4° C. with 100 uL/well of the cell lysa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2018
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM193647(US9199949, 2)
Affinity DataEC50:  8.80nMT: 2°CAssay Description:The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM193648(US9199949, 4)
Affinity DataEC50:  5.20nMT: 2°CAssay Description:The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM193649(US9199949, 6)
Affinity DataEC50:  5.10nMT: 2°CAssay Description:The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM193650(US9199949, 8)
Affinity DataEC50:  4.70nMT: 2°CAssay Description:The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM50323697(thiamet-G | (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(H...)
Affinity DataEC50:  13nMT: 2°CAssay Description:The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM205418(US9243020, (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hy...)
Affinity DataEC50:  10nMT: 2°CAssay Description:The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM205420(US9243020, 2 | US9815861, Example 2)
Affinity DataEC50:  365nMT: 2°CAssay Description:The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM205421(US9243020, 4 | US9815861, Example 4)
Affinity DataEC50:  358nMT: 2°CAssay Description:The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM205422(US9243020, 9 | US9815861, Example 9)
Affinity DataEC50:  307nMT: 2°CAssay Description:The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM205423(US9243020, 17 | US9815861, Example 17)
Affinity DataEC50:  34nMT: 2°CAssay Description:The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM205424(US9243020, 19 | US9815861, Example 19)
Affinity DataEC50:  53nMT: 2°CAssay Description:The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM205425(US9243020, 20 | US9815861, Example 20)
Affinity DataEC50:  6nMT: 2°CAssay Description:The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513930(CHEMBL4543991)
Affinity DataEC50:  176nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513931(CHEMBL4444446)
Affinity DataEC50:  11nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513934(CHEMBL4443587)
Affinity DataEC50:  1.70nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM205419(US9243020, 1 | US9815861, Example 1)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin) assessed as CYP3A4 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50323697(thiamet-G | (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(H...)
Affinity DataEC50:  14nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513955(CHEMBL4483089)
Affinity DataEC50:  37nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513956(CHEMBL4448352)
Affinity DataEC50:  443nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513957(CHEMBL4456515)
Affinity DataEC50:  509nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM141965(US8927507, 16)
Affinity DataEC50:  152nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513958(CHEMBL4473252)
Affinity DataEC50:  177nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513951(CHEMBL4583010)
Affinity DataEC50:  445nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513950(CHEMBL4454814)
Affinity DataEC50:  224nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM205421(US9243020, 4 | US9815861, Example 4)
Affinity DataEC50:  358nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513939(CHEMBL4516713)
Affinity DataEC50:  33nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM142083(US8933040, 7)
Affinity DataEC50:  165nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513947(CHEMBL4545886)
Affinity DataEC50:  28nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513960(CHEMBL4561925)
Affinity DataEC50:  41nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM205425(US9243020, 20 | US9815861, Example 20)
Affinity DataEC50:  31nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM205428(US9243020, 33 | US9815861, Example 33)
Affinity DataEC50:  58nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50323697(thiamet-G | (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(H...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin) assessed as CYP3A4 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50513962(CHEMBL4577980)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin) assessed as CYP3A4 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50513955(CHEMBL4483089)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin) assessed as CYP3A4 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50513937(CHEMBL4520749)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin) assessed as CYP3A4 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM205420(US9243020, 2 | US9815861, Example 2)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin) assessed as CYP3A4 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50513956(CHEMBL4448352)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin) assessed as CYP3A4 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50513936(CHEMBL4570378)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin) assessed as CYP3A4 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50513941(CHEMBL4519186)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin) assessed as CYP3A4 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50513930(CHEMBL4543991)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin) assessed as CYP3A4 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM50323697(thiamet-G | (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(H...)
Affinity DataEC50:  21nMAssay Description:Inhibition of OGA (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM205423(US9243020, 17 | US9815861, Example 17)
Affinity DataEC50:  34nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM205424(US9243020, 19 | US9815861, Example 19)
Affinity DataEC50:  53nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM205422(US9243020, 9 | US9815861, Example 9)
Affinity DataEC50:  307nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50513949(CHEMBL4476839)
Affinity DataEC50:  328nMAssay Description:Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
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