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TargetBotulinum neurotoxin type A(Clostridium botulinum)
TBA

Curated by ChEMBL
LigandPNGBDBM43865(6-formyl-4,7-dihydroxy-9-keto-5H-phenazine-1-carbo...)
Affinity DataKi:  6.70E+3nMAssay Description:Non-competitive inhibition of Clostridium botulinum neurotoxin serotype A light chain using 66-mer peptide by LC/MS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221566(4-chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221553(4-(7-(2-chloro-5-hydroxyphenyl)-5-methylbenzo[e][1...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221547(4-chloro-3-(5-methyl-3-(4-(3-(pyrrolidin-1-yl)prop...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50221556(4-chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221566(4-chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50221566(4-chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50221547(4-chloro-3-(5-methyl-3-(4-(3-(pyrrolidin-1-yl)prop...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221553(4-(7-(2-chloro-5-hydroxyphenyl)-5-methylbenzo[e][1...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221563((4-(7-(2-chloro-5-hydroxyphenyl)-5-methylbenzo[e][...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221556(4-chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50221553(4-(7-(2-chloro-5-hydroxyphenyl)-5-methylbenzo[e][1...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221547(4-chloro-3-(5-methyl-3-(4-(3-(pyrrolidin-1-yl)prop...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221556(4-chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221563((4-(7-(2-chloro-5-hydroxyphenyl)-5-methylbenzo[e][...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  7nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataIC50:  10nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataIC50:  14nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198813(7-(2-chlorophenyl)-5-methyl-N-(4-(2-(pyrrolidin-1-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198813(7-(2-chlorophenyl)-5-methyl-N-(4-(2-(pyrrolidin-1-...)
Affinity DataIC50:  35nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Institute of Technology & Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50226181((3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-...)
Affinity DataIC50:  46nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of DNA supercoiling after 30 mins by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198805(5-methyl-7-phenyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)...)
Affinity DataIC50:  110nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional activator protein LasR(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50351511(CHEMBL463321)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at Pseudomonas aeruginosa LasR receptor expressed in Escherichia coli in presence of 7.5 nM natural auto-inducer 3-oxo-C12-HSLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataIC50:  130nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional activator protein LasR(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50351509(CHEMBL8799)
Affinity DataIC50:  250nMAssay Description:Antagonist activity at Pseudomonas aeruginosa LasR receptor expressed in Escherichia coli in presence of 7.5 nM natural auto-inducer 3-oxo-C12-HSLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional activator protein LasR(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50241433((S)-3-(4-bromophenyl)-N-(2-oxo-tetrahydrofuran-3-y...)
Affinity DataIC50:  340nMAssay Description:Antagonist activity at Pseudomonas aeruginosa LasR receptor expressed in Escherichia coli in presence of 7.5 nM natural auto-inducer 3-oxo-C12-HSLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198805(5-methyl-7-phenyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)...)
Affinity DataIC50:  340nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCviR transcriptional regulator(Chromobacterium violaceum)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50351516(CHEMBL1823953)
Affinity DataIC50:  377nMAssay Description:Inhibition of Chromobacterium violaceum CviR-dependent GFP fluorescence in Escherichia coliMore data for this Ligand-Target Pair
TargetTranscriptional activator protein LuxR(Vibrio fischeri)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50351509(CHEMBL8799)
Affinity DataIC50:  400nMAssay Description:Antagonist activity at Vibrio fischeri luxR receptor in presence of 5 uM 3-oxo-C6-HSLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional activator protein TraR(Agrobacterium tumefaciens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50266198((S)-N-(2-oxotetrahydrofuran-3-yl)-2-(4-(trifluorom...)
Affinity DataIC50:  460nMAssay Description:Antagonist activity at Agrobacterium tumefaciens TraR receptor in presence of 100 nM 3-oxo-C8-HSLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50147729(CHEMBL3765483)
Affinity DataIC50:  520nMAssay Description:Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ format...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50221563((4-(7-(2-chloro-5-hydroxyphenyl)-5-methylbenzo[e][...)
Affinity DataIC50:  530nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50198805(5-methyl-7-phenyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)...)
Affinity DataIC50:  530nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50147691(CHEMBL3764865)
Affinity DataIC50:  530nMAssay Description:Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ format...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  560nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50147716(CHEMBL3763241)
Affinity DataIC50:  580nMAssay Description:Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ format...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
TBA

Curated by ChEMBL
LigandPNGBDBM50561055(CHEMBL4742073)
Affinity DataIC50:  587nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain using SNAPtide as substrate preincubated with enzyme for 2 mins followed by substrate addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscriptional activator protein LuxR(Vibrio fischeri)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50266165((S)-N-(2-oxotetrahydrofuran-3-yl)-2-(4-(trifluorom...)
Affinity DataIC50:  610nMAssay Description:Antagonist activity at Vibrio fischeri luxR receptor in presence of 5 uM 3-oxo-C6-HSLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50147695(CHEMBL3765314)
Affinity DataIC50:  640nMAssay Description:Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ format...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50147715(CHEMBL3764614)
Affinity DataIC50:  670nMAssay Description:Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ format...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50147724(CHEMBL3764280)
Affinity DataIC50:  690nMAssay Description:Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ format...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional activator protein TraR(Agrobacterium tumefaciens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50300132(CHEMBL584972 | N-heptanoyl-L-homoserine lactone)
Affinity DataIC50:  690nMAssay Description:Antagonist activity at Agrobacterium tumefaciens TraR receptor in presence of 100 nM 3-oxo-C8-HSLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50147725(CHEMBL3765736)
Affinity DataIC50:  740nMAssay Description:Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ format...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional activator protein LuxR(Vibrio fischeri)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50351508(CHEMBL259352)
Affinity DataIC50:  770nMAssay Description:Antagonist activity at Vibrio fischeri luxR receptor in presence of 5 uM 3-oxo-C6-HSLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional activator protein TraR(Agrobacterium tumefaciens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50351508(CHEMBL259352)
Affinity DataIC50:  770nMAssay Description:Antagonist activity at Agrobacterium tumefaciens TraR receptor in presence of 100 nM 3-oxo-C8-HSLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional activator protein TraR(Agrobacterium tumefaciens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50266165((S)-N-(2-oxotetrahydrofuran-3-yl)-2-(4-(trifluorom...)
Affinity DataIC50:  810nMAssay Description:Antagonist activity at Agrobacterium tumefaciens TraR receptor in presence of 100 nM 3-oxo-C8-HSLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50147732(CHEMBL3764694)
Affinity DataIC50:  840nMAssay Description:Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ format...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional activator protein LuxR(Vibrio fischeri)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50266163((S)-2-(4-iodophenyl)-N-(2-oxotetrahydrofuran-3-yl)...)
Affinity DataIC50:  860nMAssay Description:Antagonist activity at Vibrio fischeri luxR receptor in presence of 5 uM 3-oxo-C6-HSLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional activator protein TraR(Agrobacterium tumefaciens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50241433((S)-3-(4-bromophenyl)-N-(2-oxo-tetrahydrofuran-3-y...)
Affinity DataIC50:  920nMAssay Description:Antagonist activity at Agrobacterium tumefaciens TraR receptor in presence of 100 nM 3-oxo-C8-HSLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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