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TargetChromobox protein homolog 7(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189695(CHEMBL1198405)
Affinity DataKd:  2.38E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells assessed as compound/protein/F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetProtein Tat(HIV-1)
TBA

Curated by ChEMBL
LigandPNGBDBM50476285(CHEMBL609729)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of Tat-mediated transcription of viral promoter in 293 T cells transfected with HIV1 tat by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetChromobox protein homolog 7(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189780(CHEMBL3827954)
Affinity DataKd:  1.25E+5nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells assessed as compound/protein/F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein Tat(HIV-1)
TBA

Curated by ChEMBL
LigandPNGBDBM50398244(CHEMBL609728)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of Tat-mediated transcription of viral promoter in 293 T cells transfected with HIV1 tat by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetChromobox protein homolog 7(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189695(CHEMBL1198405)
Affinity DataKd:  5.00E+5nMAssay Description:Binding affinity to 15N-labeled CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells by HSQC/NMR titrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetEEF1AKMT4-ECE2 readthrough transcript protein(Human)
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271179(2-(2-(quinolin-2-yl)vinyl)phenol | CHEMBL487942 | ...)
Affinity DataIC50: 4.63E+3nMAssay Description:Reduction of recombinant ECE2 activity measured by McaBk2 fluorescent substrate hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEEF1AKMT4-ECE2 readthrough transcript protein(Human)
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271178(1-(pyrrolidin-1-yl)-2-(quinoxalin-6-yl)ethanone | ...)
Affinity DataIC50: 5.83E+3nMAssay Description:Reduction of recombinant ECE2 activity measured by McaBk2 fluorescent substrate hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEEF1AKMT4-ECE2 readthrough transcript protein(Human)
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50001270(CHEMBL127545 | 2-(2-(quinolin-2-yl)vinyl)phenol | ...)
Affinity DataIC50: 6.42E+3nMAssay Description:Reduction of recombinant ECE2 activity measured by McaBk2 fluorescent substrate hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEEF1AKMT4-ECE2 readthrough transcript protein(Human)
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271180(2-(2-hydroxy-3-methoxystyryl)quinolin-8-ol | CHEMB...)
Affinity DataIC50: 3.29E+4nMAssay Description:Reduction of recombinant ECE2 activity measured by McaBk2 fluorescent substrate hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEEF1AKMT4-ECE2 readthrough transcript protein(Human)
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271181(cid_5731702 | CHEMBL488140 | 2-(3-methoxystyryl)qu...)
Affinity DataIC50: 3.57E+4nMAssay Description:Reduction of recombinant ECE2 activity measured by McaBk2 fluorescent substrate hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeprilysin(Human)
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271178(1-(pyrrolidin-1-yl)-2-(quinoxalin-6-yl)ethanone | ...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of NeprilysinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeprilysin(Human)
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50001270(CHEMBL127545 | 2-(2-(quinolin-2-yl)vinyl)phenol | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of NeprilysinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetChromobox protein homolog 7(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189696(CHEMBL3827924)
Affinity DataKi:  4.80E+3nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetChromobox protein homolog 7(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189697(CHEMBL3827733)
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetChromobox protein homolog 7(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189699(CHEMBL3827834)
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetChromobox protein homolog 7(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189698(CHEMBL3827336)
Affinity DataKi:  1.69E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetChromobox protein homolog 7(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189711(CHEMBL3827805)
Affinity DataKi:  2.50E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetChromobox protein homolog 7(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189780(CHEMBL3827954)
Affinity DataKi:  3.31E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChromobox protein homolog 7(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189762(CHEMBL3827451)
Affinity DataKi:  3.93E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed