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TargetActivin receptor type-1(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 0.670nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetActivin receptor type-1(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM102619(K02288a | US10688093, Compound 382_0087_0284 | US1...)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2013
Entry Details Article
PubMed
TargetActivin receptor type-1(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM102618(LDN-212854)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase receptor R3(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 1.48nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase receptor R3(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM102618(LDN-212854)
Affinity DataIC50: 2.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase receptor R3(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM102619(K02288a | US10688093, Compound 382_0087_0284 | US1...)
Affinity DataIC50: 3.65nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM143311(US9682983, 11 | US10017516, Compound 11)
Affinity DataIC50: 4nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM111123(US9682983, 2 | US10017516, Compound 2)
Affinity DataIC50: 4nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM143311(US9682983, 11 | US10017516, Compound 11)
Affinity DataIC50: 4nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM161920(US9682983, 52 | US9682983, 53 | US10017516, Compou...)
Affinity DataIC50: 4nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetActivin receptor type-1(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM50056508(CHEMBL3341945)
Affinity DataIC50: 4nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM111123(US9682983, 2 | US10017516, Compound 2)
Affinity DataIC50: 5.80nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM111123(US9682983, 2 | US10017516, Compound 2)
Affinity DataIC50: 5.80nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetActivin receptor type-1(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM50056507(CHEMBL3341944)
Affinity DataIC50: 6nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50056506(CHEMBL3341943 | US10688093, Compound 382_0087_6488...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM111123(US9682983, 2 | US10017516, Compound 2)
Affinity DataIC50: 6.5nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM161920(US9682983, 52 | US9682983, 53 | US10017516, Compou...)
Affinity DataIC50: 6.5nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM143311(US9682983, 11 | US10017516, Compound 11)
Affinity DataIC50: 7.70nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM143311(US9682983, 11 | US10017516, Compound 11)
Affinity DataIC50: 7.70nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM161920(US9682983, 52 | US9682983, 53 | US10017516, Compou...)
Affinity DataIC50: 8nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM161920(US9682983, 52 | US9682983, 53 | US10017516, Compou...)
Affinity DataIC50: 8nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM111123(US9682983, 2 | US10017516, Compound 2)
Affinity DataIC50: 8.60nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM161920(US9682983, 52 | US9682983, 53 | US10017516, Compou...)
Affinity DataIC50: 8.60nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM111123(US9682983, 2 | US10017516, Compound 2)
Affinity DataIC50: 9.10nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM111123(US9682983, 2 | US10017516, Compound 2)
Affinity DataIC50: 9.10nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM143311(US9682983, 11 | US10017516, Compound 11)
Affinity DataIC50: 9.20nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 9.76nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM111123(US9682983, 2 | US10017516, Compound 2)
Affinity DataIC50: 10nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50056508(CHEMBL3341945)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50056680(CHEMBL3341794)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM111123(US9682983, 2 | US10017516, Compound 2)
Affinity DataIC50: 10nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM108945(US9682983, 48 | US10017516, Compound 48)
Affinity DataIC50: 11nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM108945(US9682983, 48 | US10017516, Compound 48)
Affinity DataIC50: 11nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM127883(US9682983, 6 | US10017516, Compound 6)
Affinity DataIC50: 12nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM127883(US9682983, 6 | US10017516, Compound 6)
Affinity DataIC50: 12nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36354(DMH1 | 4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyr...)
Affinity DataIC50: 12.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2013
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM161910(US9682983, 42 | US10017516, Compound 42)
Affinity DataIC50: 14nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM161910(US9682983, 42 | US10017516, Compound 42)
Affinity DataIC50: 14nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50056510(CHEMBL3341947)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1A(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 14.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBone morphogenetic protein receptor type-1B(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM148348(US9682983, 22 | US10017516, Compound 22)
Affinity DataIC50: 15nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM160069(US9682983, 39 | US10017516, Compound 39)
Affinity DataIC50: 15nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50056675(CHEMBL3341787)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM148348(US9682983, 22 | US10017516, Compound 22)
Affinity DataIC50: 15nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM160069(US9682983, 39 | US10017516, Compound 39)
Affinity DataIC50: 15nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM118134(US9682983, 3 | US10017516, Compound 3)
Affinity DataIC50: 16nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM143566(US9682983, 13 | US10017516, Compound 13)
Affinity DataIC50: 16nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM161914(US9682983, 46 | US10017516, Compound 46)
Affinity DataIC50: 16nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM118134(US9682983, 3 | US10017516, Compound 3)
Affinity DataIC50: 16nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM50056508(CHEMBL3341945)
Affinity DataIC50: 16nMAssay Description:Inhibition of BMP2-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
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