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TargetProtein disulfide-isomerase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50523101(CHEMBL4545330)
Affinity DataKd:  9.10E+3nMAssay Description:Binding affinity to recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein disulfide-isomerase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50523101(CHEMBL4545330)
Affinity DataKd:  9.80E+3nMAssay Description:Binding affinity to recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS by ROX dye based thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein disulfide-isomerase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50523101(CHEMBL4545330)
Affinity DataKd:  1.23E+4nMAssay Description:Binding affinity to recombinant full-length human His-tagged PDI expressed in Escherichia coli Origami B (DE3) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50121972(Compound 3 | CHEMBL157373)
Affinity DataEC50:  1.78E+4nMAssay Description:Effective concentration of the compound against viral replication by Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50121971(2-Mercapto-benzoic acid N'-(2-mercapto-benzoyl)-hy...)
Affinity DataEC50:  4.30E+3nMAssay Description:Effective concentration of the compound against viral replication by Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50121970(11,12,13,14,25,26,27,28-octahydrotetrabenzo[c,i,m,...)
Affinity DataEC50:  6.00E+3nMAssay Description:Effective concentration of the compound against viral replication by Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50396177(NIFUROXAZIDE)
Affinity DataEC50:  3.00E+3nMAssay Description:Inhibition of STAT3 expressed in human U3A cells after 1 hr by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Mouse)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50353441(CHEMBL1829786)
Affinity DataKd:  2.74E+3nMAssay Description:Binding affinity to STAT3 SH2 in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50191290(3-(5-(2-chloro-4,5-dimethoxybenzylidene)-3-methyl-...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of [125I]echistatin binding to integrin alphaVbeta3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601761(CHEMBL5203869 | US11773078, Example 263)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601763(CHEMBL5197625 | US11773078, Example 62)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGlutathione S-transferase omega-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50526135(CHEMBL4593975)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of CMFDA binding to human N-terminal 6x-His-tagged GSTO1-1 preincubated for 30 mins followed by CMFDA addition and measured after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601747(CHEMBL5175553 | US11773078, Example 11)
Affinity DataIC50: 0.251nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGlutathione S-transferase omega-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50526136(CHEMBL4513682)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of CMFDA binding to human N-terminal 6x-His-tagged GSTO1-1 preincubated for 30 mins followed by CMFDA addition and measured after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601762(CHEMBL5190891 | US11773078, Example 369)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601703(CHEMBL5202322)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of furin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601704(CHEMBL5184039)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of furin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601759(CHEMBL5175809 | US11773078, Example 298)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601749(CHEMBL5171461 | US11773078, Example 180)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601750(CHEMBL5182363 | US11773078, Example 41)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601754(CHEMBL5208861 | US11773078, Example 207)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601757(CHEMBL5206910 | US11773078, Example 131)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601755(CHEMBL5195577 | US11773078, Example 126)
Affinity DataIC50: 1nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50271272(N-(1-benzyl-1H-indazol-5-yl)-6-(5-((2-(methylsulfo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50271271((R)-N-(3-chloro-4-(pyrazin-2-ylmethoxy)phenyl)-5-(...)
Affinity DataIC50: 1nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601756(CHEMBL5196204 | US11773078, Example 334)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601760(CHEMBL5180159 | US11773078, Example 306)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601752(CHEMBL5172689 | US11773078, Example 340)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601746(CHEMBL5172764 | US11773078, Example 10)
Affinity DataIC50: 2nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601751(CHEMBL5200817 | US11773078, Example 339)
Affinity DataIC50: 2nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50270524(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601753(CHEMBL5207406 | US11773078, Example 206)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601758(CHEMBL5170962 | US11773078, Example 242)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50161875(E[c(RGDyK)]2 | CHEMBL414385)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human metastatic breast cancer (MDA-MB-435) cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601702(CHEMBL5199257)
Affinity DataIC50: 3nMAssay Description:Inhibition of furin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50477992(CHEMBL429327)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50477985(CHEMBL412149)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50270525((5-(4-(4-(benzyloxy)phenylamino)pyrido[3,4-d]pyrim...)
Affinity DataIC50: 4nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50477985(CHEMBL412149)
Affinity DataIC50: 5nMAssay Description:Inhibition of HIV1 integrase 3'-end processing activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50477995(CHEMBL407352)
Affinity DataIC50: 5nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50477993(CHEMBL406595)
Affinity DataIC50: 5nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50477998(CHEMBL272420)
Affinity DataIC50: 5nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601748(CHEMBL5169887 | US11773078, Example 12)
Affinity DataIC50: 5nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGlutathione S-transferase omega-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50526140(CHEMBL4463748)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of CMFDA binding to human N-terminal 6x-His-tagged GSTO1-1 preincubated for 30 mins followed by CMFDA addition and measured after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50477992(CHEMBL429327)
Affinity DataIC50: 7nMAssay Description:Inhibition of HIV1 integrase 3'-end processing activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50478002(CHEMBL408699)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of DHODH (unknown origin) expressed in Escherichia coli Rosetta2(DE3) assessed as reduction of DCIP using dihydroorotate as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50161879(N-(4-(4-(3-chlorobenzyloxy)-3-chlorophenylamino)-3...)
Affinity DataIC50: 8nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50271239(((1S,5R,6s)-3-((4-(4-(3-methoxy-4-phenoxyphenylami...)
Affinity DataIC50: 8nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50477997(CHEMBL273128)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
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