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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415001(GSK-256066 | CHEMBL570015 | GSK-256066 (3))
Affinity DataIC50: 0.00794nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414999(CHEMBL569791)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415009(CHEMBL571381)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769283((5R)-5'-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methy...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769147((S)-5-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769146(5-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415008(CHEMBL584327)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769294((3R)-6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769276(N-[(3R)-6-[7,7-difluoro-2-[(2S,3R)-3-fluoro-2-meth...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769086((5R)-5'-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methy...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769095(6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414998(CHEMBL569556)
Affinity DataIC50: 0.126nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585527(CHEMBL5084861)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769271(N-[6-[7,7-difluoro-2-[(2S,3R)-3-fluoro-2-methyl-az...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769290(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769416(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769084((S)-5'-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyl...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769126(N-((R)-6-(7,7-difluoro-2-((S)-2-methylazetidin-1-y...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769081((R)-6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769286(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769097((S)-6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769074((S)-5-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM769159((S)-(5-(7,7-difluoro-2-((2S,3R)-3-fluoro-2-methyla...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769427((R)-6-(7,7-difluoro-2-((R)-2-(trifluoromethyl)azet...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769299((3S)-6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769157((3S)-6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyl...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM769161((S)-(5-(2-((S)-3,3-difluoro-2-methylazetidin-1-yl)...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769282((5R)-5'-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methy...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769156(6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769297(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769394(3-amino-3-(4-(7,7-difluoro-2-((2S,3R)-3-fluoro-2-m...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769273((5S)-5'-[7,7-difluoro-2-[(2R)-2-(fluoromethyl)azet...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316949((3R)-3-((3-((2-oxo-1,2,3,4-tetrahydroquinolin-7-yl...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769296(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769423((S)-6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769287(6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM769160((S)-(5-(7,7-difluoro-2-((2S,3S)-3-fluoro-2-methyla...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769235((S)-5-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769079(6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769272(N-[6-[7,7-difluoro-2-[(2S,3R)-3-fluoro-2-methyl-az...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413296(CHEMBL473764)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585527(CHEMBL5084861)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413297(CHEMBL473560)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetKetohexokinase(Human)TBA
LigandPNGBDBM769185(3-[4-[7,7-difluoro-2-[(2R)-2-(trifluoromethyl)azet...)
Affinity DataIC50: 0.400nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
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