Compile Data Set for Download or QSAR
Report error Found 293 with Last Name = 'ni' and Initial = 'zj'
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452147(CHEMBL4204192)
Affinity DataEC50:  770nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452153(CHEMBL4211935)
Affinity DataEC50:  540nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452149(CHEMBL4216073)
Affinity DataEC50:  230nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452148(CHEMBL4209163)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452152(CHEMBL4217462)
Affinity DataEC50:  25nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452151(CHEMBL4208527)
Affinity DataEC50:  240nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452150(CHEMBL4216386)
Affinity DataEC50:  480nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452154(CHEMBL4205266)
Affinity DataEC50:  130nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Institute of Medical Biology Pas

Curated by ChEMBL
LigandPNGBDBM50452336(CHEMBL2113406)
Affinity DataEC50:  54nMAssay Description:Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Institute of Medical Biology Pas

Curated by ChEMBL
LigandPNGBDBM50573587(CHEMBL4861092)
Affinity DataEC50:  16nMAssay Description:Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Institute of Medical Biology Pas

Curated by ChEMBL
LigandPNGBDBM50573589(CHEMBL4864883)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM50577482(CHEMBL4848550)
Affinity DataEC50:  4.40E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM50577483(CHEMBL4869437)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM50577484(CHEMBL4863873)
Affinity DataEC50:  780nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataEC50:  290nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataEC50:  7.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349513(US10207991, Ex. Cpd. No. 28 | US10611728, Example ...)
Affinity DataEC50:  9.60E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataEC50:  2.60E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50336866(3-(2-morpholino-6-(quinolin-3-ylamino)pyrimidin-4-...)
Affinity DataEC50:  370nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336867(N-(2-morpholino-6-(pyridin-3-yl)pyrimidin-4-yl)qui...)
Affinity DataEC50:  650nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336868(N-(6-(6-aminopyridin-3-yl)-2-morpholinopyrimidin-4...)
Affinity DataEC50:  310nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336871(N-(2-morpholino-6-(pyrazin-2-yl)pyrimidin-4-yl)qui...)
Affinity DataEC50:  390nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336872(N-(6-(5-aminopyrazin-2-yl)-2-morpholinopyrimidin-4...)
Affinity DataEC50:  3.30E+3nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336873(N-(2-morpholino-4,5'-bipyrimidin-6-yl)quinolin-3-a...)
Affinity DataEC50:  450nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336880(2-morpholino-N6-(quinolin-3-yl)-4,5'-bipyrimidine-...)
Affinity DataEC50:  40nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336875(N2'-methyl-2-morpholino-N6-(quinolin-3-yl)-4,5'-bi...)
Affinity DataEC50:  110nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336881(2-morpholino-N6-(6-phenoxypyridin-3-yl)-4,5'-bipyr...)
Affinity DataEC50:  110nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336882(N6-(6-(1-methylpiperidin-4-yloxy)pyridin-3-yl)-2-m...)
Affinity DataEC50:  10nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336865(N6-(6-methoxypyridin-3-yl)-2-morpholino-4,5'-bipyr...)
Affinity DataEC50:  90nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336878(2-morpholino-N6-(tetrahydro-2H-pyran-4-yl)-4,5'-bi...)
Affinity DataEC50:  220nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336879(2-morpholino-4,5'-bipyrimidin-2'-amine | CHEMBL167...)
Affinity DataEC50:  130nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50140265(CHEMBL3753450)
Affinity DataEC50: <40nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50140266(CHEMBL3753366)
Affinity DataEC50: <40nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50140267(CHEMBL3752019)
Affinity DataEC50: <40nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50140268(CHEMBL3753085)
Affinity DataEC50:  170nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50140269(CHEMBL3752653)
Affinity DataEC50: <40nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50140270(CHEMBL3752503)
Affinity DataEC50:  60nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50140271(CHEMBL3751961)
Affinity DataEC50:  150nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50140272(CHEMBL3754572)
Affinity DataEC50: <40nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50140273(CHEMBL3752760)
Affinity DataEC50:  110nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50439721(CHEMBL2418953)
Affinity DataEC50: <40nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50140274(CHEMBL3753665)
Affinity DataEC50:  270nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50140275(CHEMBL3752775)
Affinity DataEC50:  90nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50439711(CHEMBL2418954)
Affinity DataEC50:  80nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452149(CHEMBL4216073)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant C-terminal his6-tagged B-Raf (437 to 765 residues) V600E mutant (unknown origin) catalytic domain expressed in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452150(CHEMBL4216386)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant C-terminal his6-tagged B-Raf (437 to 765 residues) V600E mutant (unknown origin) catalytic domain expressed in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452152(CHEMBL4217462)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant C-terminal his6-tagged B-Raf (437 to 765 residues) V600E mutant (unknown origin) catalytic domain expressed in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM50185219((S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinu...)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM50185221((S)-3-(1H-benzo[d]imidazol-2-yl)-6-methyl-4-(quinu...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM50185218((S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(pyrro...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Displayed 1 to 50 (of 293 total ) | Next | Last >>
Jump to: