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TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111907(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111909(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111910(9-Chloro-3-methyl-5-{3-[2-(3,4,5-trimethoxy-phenox...)
Affinity DataEC50:  1.47E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111912(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  2.10E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111911(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  3.70E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111913(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  1.80E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111917(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111916(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  4.90E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111918(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  2.30E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111919(N-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  1.13E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111920(N-Benzo[1,3]dioxol-5-yl-2-[3-(9-chloro-3-methyl-4-...)
Affinity DataEC50:  4.00E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111921(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  4.10E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111915(LY-402913 | 2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxa...)
Affinity DataEC50:  900nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111914(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  1.30E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111922(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  3.20E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111923(9-Chloro-3-methyl-5-{3-[(3,4,5-trimethoxy-benzylam...)
Affinity DataEC50:  1.77E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111924(5-Methyl-isoxazole-3-carboxylic acid 3-(9-chloro-3...)
Affinity DataEC50:  7.90E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111925(4-{2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111926(5-Methyl-isoxazole-3-carboxylic acid [(1R,2R)-6-(9...)
Affinity DataEC50:  1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111927(N-(4-tert-Butyl-phenyl)-2-[3-(9-chloro-3-methyl-4-...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111908(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  640nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50174854(N-(((1R,3S)-3-(9-chloro-3-methyl-4-oxoisoxazolo[4,...)
Affinity DataEC50:  180nMAssay Description:Inhibitory activity against MRP1 in HeLa-T5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50174852(rac-N-((3-(9-chloro-3-methyl-4-oxoisoxazolo[4,3-c]...)
Affinity DataEC50:  250nMAssay Description:Inhibitory activity against MRP1 in HeLa-T5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50174855(rac-N-((3-(9-chloro-3-methyl-4-oxoisoxazolo[4,3-c]...)
Affinity DataEC50:  420nMAssay Description:Inhibitory activity against MRP1 in HeLa-T5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50174853(rac-N-((3-(9-chloro-3-methyl-4-oxoisoxazolo[4,3-c]...)
Affinity DataEC50:  640nMAssay Description:Inhibitory activity against MRP1 in HeLa-T5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataEC50:  2.20E+4nMAssay Description:Inhibition of NGF-induced TrkA auto-phosphorylation in rat PC12 cells incubated for 15 mins by chemiluminescence based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM164885(US9067914, Ex. 3-1 | US10166239, Ex. 3-1 | US11406...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal GST tagged human TrkA cytoplasmic domain (436 to 790 amino acids) pre-incubated for 15 mins before peptide substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM164885(US9067914, Ex. 3-1 | US10166239, Ex. 3-1 | US11406...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal GST tagged human TrkB cytoplasmic domain (456 to 822 amino acids) pre-incubated for 15 mins before peptide substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50028854(CHEMBL3342693)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194141(CHEMBL3938686)
Affinity DataIC50: 1nMAssay Description:Inhibition of human mPGES-1 expressed in 293E cells assessed as reduction in conversion of PGH2 to PGE2 after 1.5 min by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2018
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194190(CHEMBL3956184)
Affinity DataIC50: 1nMAssay Description:Inhibition of mPGES-1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS stimulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2018
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194190(CHEMBL3956184)
Affinity DataIC50: 1nMAssay Description:Inhibition of human mPGES-1 expressed in 293E cells assessed as reduction in conversion of PGH2 to PGE2 after 1.5 min by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2018
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233277(CHEMBL4085873)
Affinity DataIC50: 1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233278(CHEMBL4064335)
Affinity DataIC50: 1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233281(CHEMBL4084995)
Affinity DataIC50: 1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233283(CHEMBL4102262)
Affinity DataIC50: 1nMAssay Description:Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233285(CHEMBL4101413)
Affinity DataIC50: 1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233283(CHEMBL4102262)
Affinity DataIC50: 1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
LigandPNGBDBM204931(Example 1 | [2-(indan-2-ylamino)-7,8-dihydro-5H-py...)
Affinity DataIC50: 1.70nMAssay Description:The purpose of this assay is to detect autotaxin inhibition using a choline release assay.Test compound (10 mM stocks in 100% DMSO) is serially dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2018
Entry Details
Go to US Patent

LigandPNGBDBM50187689(CHEMBL3827513 | Example 9)
Affinity DataIC50: 1.70nMAssay Description:The purpose of this assay is to detect autotaxin inhibition using a choline release assay.Test compound (10 mM stocks in 100% DMSO) is serially dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2018
Entry Details
Go to US Patent

LigandPNGBDBM50535210(CHEMBL4448598)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant full length human C-terminal His-tagged autotaxin expressed in human 293E cells assessed as choline release using lysophosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194138(CHEMBL3928608)
Affinity DataIC50: 2nMAssay Description:Inhibition of human mPGES-1 expressed in 293E cells assessed as reduction in conversion of PGH2 to PGE2 after 1.5 min by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194141(CHEMBL3938686)
Affinity DataIC50: 2nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in recombinant human interleukin-1 beta-induced PGE2 production preincubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2018
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194141(CHEMBL3938686)
Affinity DataIC50: 2nMAssay Description:Inhibition of mPGES-1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS stimulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2018
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233274(CHEMBL4067045)
Affinity DataIC50: 2nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233276(CHEMBL4078000)
Affinity DataIC50: 2nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233280(CHEMBL4063350)
Affinity DataIC50: 2nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233284(CHEMBL4071976)
Affinity DataIC50: 2nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
LigandPNGBDBM50535213(CHEMBL4453084)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of recombinant full length human C-terminal His-tagged autotaxin expressed in human 293E cells assessed as choline release using lysophosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50535210(CHEMBL4448598)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of autotaxin in healthy human plasma assessed as reduction in LPA level after 3 hrs by mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
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