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TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50573875(CHEMBL4869086)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418177(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 1.10nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418177(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 1.10nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418177(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418281(US10457669, Example 1072 | (2R)-2-[6-(5-chloro-2-{...)
Affinity DataIC50: 1.20nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418281(US10457669, Example 1072 | (2R)-2-[6-(5-chloro-2-{...)
Affinity DataIC50: 1.20nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417953(US10457669, Example 614 | US11001575, Example 616)
Affinity DataIC50: 1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417999(US10457669, Example 675 | US11001575, Example 675)
Affinity DataIC50: 1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417999(US10457669, Example 675 | US11001575, Example 675)
Affinity DataIC50: 1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetKelch-like ECH-associated protein 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50180850(CHEMBL3819587)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to human recombinant N-terminal His6 and Avi-tagged KEAP1 (321 to 609 residues) expressed in baculovirus infected sf9 cells by isoth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417999(US10457669, Example 675 | US11001575, Example 675)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418188(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418188(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417954(US10457669, Example 615)
Affinity DataIC50: 1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418223((2R)-2-(3-{5-chloro-2-[(2-methyl-2H- 1,2,3-triazol...)
Affinity DataIC50: 1.40nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418223((2R)-2-(3-{5-chloro-2-[(2-methyl-2H- 1,2,3-triazol...)
Affinity DataIC50: 1.40nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418230((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 1.40nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418230((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 1.40nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418266(US10457669, Example 1048 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418192(US10457669, Example 952 | US10457669, Example 953 ...)
Affinity DataIC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418305(US10457669, Example 1112 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418266(US10457669, Example 1048 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418229((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418305(US10457669, Example 1112 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418192(US10457669, Example 952 | US10457669, Example 953 ...)
Affinity DataIC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418307(US10457669, Example 1114 | (2R)-2-(6-}5-chloro-2-[...)
Affinity DataIC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418229((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418307(US10457669, Example 1114 | (2R)-2-(6-}5-chloro-2-[...)
Affinity DataIC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417711(2-(6-{5-bromo-2- [(oxan-4- yl)amino]pyrimidiin-4- ...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418276(US10457669, Example 1063 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM497509(2-(6-{5-chloro-2-[(oxan- 4-yl)amino]pyrimidin-4- y...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418276(US10457669, Example 1063 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418308(US10457669, Example 1115 | (2R)-2-[6-(5-chloro-2-{...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418298(US10457669, Example 1095 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418133(US10457669, Example 872 | (2R)-2-(6-{5-chloro-2-[(...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418200(US10457669, Example 962 | (2R)-2-(6-{5-chloro-2-[(...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418300(US10457669, Example 1105 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418300(US10457669, Example 1105 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418298(US10457669, Example 1095 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418200(US10457669, Example 962 | (2R)-2-(6-{5-chloro-2-[(...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418308(US10457669, Example 1115 | (2R)-2-[6-(5-chloro-2-{...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417812(US10457669, Example 450)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418133(US10457669, Example 872 | (2R)-2-(6-{5-chloro-2-[(...)
Affinity DataIC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417813(US10457669, Example 451 | US11001575, Example 451)
Affinity DataIC50: 1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418192(US10457669, Example 952 | US10457669, Example 953 ...)
Affinity DataIC50: 1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418089(US10457669, Example 803 | (2R)-2-{6-[5-chloro-2- (...)
Affinity DataIC50: 1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM498075((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimid i...)
Affinity DataIC50: 1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417895(US10457669, Example 545 | US11001575, Example 545)
Affinity DataIC50: 1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417960(US10457669, Example 621 | US11001575, Example 621)
Affinity DataIC50: 1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418089(US10457669, Example 803 | (2R)-2-{6-[5-chloro-2- (...)
Affinity DataIC50: 1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

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