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TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50271367(N-Methyl-N-(1,2,3,4-tetrahydroacridin-9-yl)-N-{3-[...)
Affinity DataKi:  0.0120nMAssay Description:Inhibition of human acetylcholine esteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50271367(N-Methyl-N-(1,2,3,4-tetrahydroacridin-9-yl)-N-{3-[...)
Affinity DataKi:  0.0120nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
University of Naples&Quot;Federico Ii&Quot

Curated by ChEMBL
LigandPNGBDBM50048701(CHEMBL3315148)
Affinity DataEC50:  0.0126nMAssay Description:Agonist activity at UT receptor in rat aorta assessed as contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Pacific electric ray)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50271556(N,N,N-trimethyl-3-(2,2,2-trifluoroacetyl)benzenami...)
Affinity DataKi:  0.0150nMAssay Description:Inhibition of Torpedo californica AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
University of Naples&Quot;Federico Ii&Quot

Curated by ChEMBL
LigandPNGBDBM50048697(CHEMBL3315144)
Affinity DataEC50:  0.0195nMAssay Description:Agonist activity at UT receptor in rat aorta assessed as contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM10597((1S)-7-chloro-15-ethyl-10-azatetracyclo[11.3.1.0^{...)
Affinity DataKi:  0.0260nM ΔG°:  -60.4kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50369748(CHEMBL208599)
Affinity DataKi:  0.0260nMAssay Description:Inhibitory activity against human AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50175548(N-Hydroxy-2-(4-phenoxy-benzenesulfonylamino)-aceta...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of human recombinant MMP2 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAdenosine deaminase(Bovine)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50370598(CHEMBL1651379)
Affinity DataKi:  0.0530nMAssay Description:Inhibitory constant against bovine spleen Adenosine deaminaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
University of Siena

Curated by ChEMBL
LigandPNGBDBM8965(CHEMBL338755 | methylbis[3-(1,2,3,4-tetrahydroacri...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of fetal Bovine serum AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM8965(CHEMBL338755 | methylbis[3-(1,2,3,4-tetrahydroacri...)
Affinity DataKi:  0.0600nM ΔG°:  -58.3kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50005193(CHEMBL3099496)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human butyrylcholine esteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50318267(4-methoxy-N-(2-methyl-6-phenyl-2H-pyrazolo[3,4-d]p...)
Affinity DataIC50: 0.0610nMAssay Description:Antagonist activity at adenosine A3 receptor in human U87MG cells assessed as inhibition of Cl-IB-MECA-mediated ERK1/2 phosphorylation after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Pacific electric ray)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50149201(3,8-Diamino-6-phenyl-5-(6-{3-[2-(1,2,3,4-tetrahydr...)
Affinity DataKi:  0.0770nMAssay Description:Inhibition of Torpedo californica AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50271469(N-Allyl-N-(1,2,3,4-tetrahydroacridin-9-yl)-N-{3-[(...)
Affinity DataKi:  0.0850nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50001107(CHEMBL66018 | CHEMBL554426 | 2-(3,4-Dichloro-pheny...)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL29197 | N-(3-bromophenyl)-6,7-dimethoxyquina...)
Affinity DataIC50: 0.0950nMAssay Description:Inhibition of recombinant human EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate measured after 15 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265775(N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]i...)
Affinity DataKi:  0.0990nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50118528(Ethyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of [3H]Ro-5-4864 binding to mitochondrial rat testis Peripheral type benzodiazepine receptor (PBR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50175548(N-Hydroxy-2-(4-phenoxy-benzenesulfonylamino)-aceta...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant MMP13 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265375(N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]3...)
Affinity DataKi:  0.105nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50118528(Ethyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of [3H]PK11195 binding to Peripheral type benzodiazepine receptor (PBR) in rat cortex homogenate by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Universita Di Siena

LigandPNGBDBM8977(N-[3-(1,2,3,4-Tetrahydroacridin-9-ylamino)propyl]-...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50271470(N-(2-Hydroxyethyl)-N-(1,2,3,4-tetrahydroacridin-9-...)
Affinity DataKi:  0.119nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Technische UniversitäT MüNchen

Curated by ChEMBL
LigandPNGBDBM50177895(fluoromethyl 1-(2-phenylethyl)-4-(N-phenylpropanam...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]DAMGO from recombinant human mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine deaminase(Bovine)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50171394(2-Decyl-2H-pyrazolo[3,4-d]pyrimidin-4-ylamine | CH...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory constant against bovine spleen Adenosine deaminaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Pacific electric ray)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50369748(CHEMBL208599)
Affinity DataKi:  0.130nMAssay Description:Inhibition of Torpedo californica AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Technische UniversitäT MüNchen

Curated by ChEMBL
LigandPNGBDBM50177898(N-[1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenyl-...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]DAMGO from recombinant human mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50271471(1,4-bis[3-(1,2,3,4-Tetrahydroacridin-9-yl)aminopro...)
Affinity DataKi:  0.136nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265445(3-[5-[4-(2,3-Dichlorophenyl)piperazin-1-yl]pentylo...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50253857(N-butyl-2-(5-chloro-2-(4-chlorophenyl)-1H-indol-3-...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50171900((S)-3-Phenyl-2-(4-thiophen-2-yl-phenoxy)-propionic...)
Affinity DataEC50:  0.150nMAssay Description:Effective concentration against murine PPARalpha in transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.150nMAssay Description:Binding affinity to 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50271468(N-Ethyl-N-(1,2,3,4-tetrahydroacridin-9-yl)-N-{3-[(...)
Affinity DataKi:  0.162nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50253893(2-(5-chloro-2-(4-chlorophenyl)-1H-indol-3-yl)-N-me...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50131925(N-(4-(4-(2,4-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity for rat striatum Dopamine receptor D3 (sf9 cells) by [3H]7-OH-DPAT displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50138318((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of alpha5-beta1 integrin receptor in ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50131925(N-(4-(4-(2,4-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]-7-OH-DPAT from rat brain membrane D3 receptor expressed in Sf9 cells incubated for 60 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50318267(4-methoxy-N-(2-methyl-6-phenyl-2H-pyrazolo[3,4-d]p...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50118537(Ethyl-carbamic acid 7-chloro-5-phenyl-6-oxa-10b-az...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of [3H]PK11195 binding to Peripheral type benzodiazepine receptor (PBR) in rat cortex homogenate by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50131925(N-(4-(4-(2,4-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
University of Naples&Quot;Federico Ii&Quot

Curated by ChEMBL
LigandPNGBDBM50048691(CHEMBL3315139)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]urotensin-2 from human recombinant UT receptor expressed in CHO-K1 cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
University of Naples&Quot;Federico Ii&Quot

Curated by ChEMBL
LigandPNGBDBM50413761(CHEMBL390094)
Affinity DataKi:  0.200nMAssay Description:Binding affinity towards human Urotensin 2 receptor was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
University of Naples&Quot;Federico Ii&Quot

Curated by ChEMBL
LigandPNGBDBM50413761(CHEMBL390094)
Affinity DataKi:  0.200nMAssay Description:Ability to displace radioligand [125I]Tyr-hU-II from human recombinant Urotensin 2 receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
University of Naples&Quot;Federico Ii&Quot

Curated by ChEMBL
LigandPNGBDBM50413761(CHEMBL390094)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]urotensin-2 from human UT2 receptor expressed in CHO-K1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50465610(CHEMBL4295040)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50118528(Ethyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of [3H]PK11195 binding to mitochondrial rat testis Peripheral type benzodiazepine receptor (PBR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50031465(CHEMBL3358104)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
LigandPNGBDBM28759(CHEMBL191275 | (2S)-3-phenyl-2-(4-phenylphenoxy)pr...)
Affinity DataEC50:  0.200nMAssay Description:Effective concentration against murine PPARalpha in transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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