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TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50092019(N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-...)
Affinity DataEC50:  48nMAssay Description:Tested in vitro for its ability to stimulate increase in cAMP in CHO cells expressing the cloned human beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071280(N-(4-{2-[(S)-3-(6-Amino-pyridin-3-yloxy)-2-hydroxy...)
Affinity DataEC50:  6nMAssay Description:Evaluated for its agonist activity against human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070163(N-[4-(4-{2-[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-pr...)
Affinity DataEC50:  2.30nMAssay Description:Agonist activity towards human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090148(4-[2-((R)-4-Fluoro-3-fluoro-phenyl)-oxazol-4-yl]-N...)
Affinity DataEC50:  35nMAssay Description:In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090158(4-[2-((R)-2-Cyclopentyl-ethyl)-oxazol-4-yl]-N-{4-[...)
Affinity DataEC50:  15nMAssay Description:In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50092032(4-[4-(3,4-Difluoro-benzyl)-[1,2,3]triazol-2-yl]-N-...)
Affinity DataEC50:  7.20nMAssay Description:Tested in vitro for its ability to stimulate increase in cAMP in CHO cells expressing the cloned human beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075889(4-(3-Hexyl-2-oxo-2,3-dihydro-imidazol-1-yl)-N-{4-[...)
Affinity DataEC50:  14nMAssay Description:Agonist activity towards Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090157(4-[2-(3,4-Difluoro-benzyl)-oxazol-5-yl]-N-{4-[2-((...)
Affinity DataEC50:  11nMAssay Description:In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090159(BN-{(R)-4-[2-(2-Hydroxy-2-pyridin-3-yl-ethylamino)...)
Affinity DataEC50: >100nMAssay Description:In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071292(N-(4-{2-[(S)-2-Hydroxy-3-(4-methoxy-phenoxy)-propy...)
Affinity DataEC50:  5nMAssay Description:Evaluated for Adenylyl cyclase activation as % of the maximal stimulation with isoproterenol at 100 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070176(4-(3-Hexyl-1,3-dimethyl-ureido)-N-(4-{2-[(S)-2-hyd...)
Affinity DataEC50:  10nMAssay Description:Agonist activity towards human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090167(N-{(R)-4-[2-(2-Hydroxy-2-pyridin-3-yl-ethylamino)-...)
Affinity DataEC50:  39nMAssay Description:In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070175([4-(4-{2-[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-prop...)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity towards human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090166(N-{4-[2-(2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethy...)
Affinity DataEC50:  210nMAssay Description:In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070174(N-(4-{2-[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propy...)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity towards human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070132(N-(4-{2-[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propy...)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity towards human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075892(N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-...)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity towards Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071289(Quinoline-3-sulfonic acid (4-{2-[(S)-3-(6-amino-py...)
Affinity DataEC50:  43nMAssay Description:Evaluated for its agonist activity against human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070156((S)-4-(3-hexylureido)-N-(4-(2-(1-hydroxy-2-(4-hydr...)
Affinity DataEC50:  0.430nMAssay Description:Agonist activity towards human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090170(N-{4-[2-(2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethy...)
Affinity DataEC50:  4.30nMAssay Description:In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071287(N-(4-{2-[(S)-3-(6-Amino-pyridin-3-yloxy)-2-hydroxy...)
Affinity DataEC50:  13nMAssay Description:Evaluated for its agonist activity against human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50092031(4-[4-(4-Fluoro-phenyl)-[1,2,3]triazol-2-yl]-N-{4-[...)
Affinity DataEC50:  24nMAssay Description:Tested in vitro for its ability to stimulate increase in cAMP in CHO cells expressing the cloned human beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070168([4-(4-{2-[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-prop...)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity towards human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071285(4-Bromo-N-(4-{2-[(S)-2-hydroxy-3-(pyridin-3-yloxy)...)
Affinity DataEC50:  22nMAssay Description:Evaluated for its agonist activity against human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075885(N-{4-[2-(2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethy...)
Affinity DataEC50:  60nMAssay Description:Agonist activity towards Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090152(4-[2-((R)-4-Fluoro-phenoxymethyl)-oxazol-4-yl]-N-{...)
Affinity DataEC50:  19nMAssay Description:In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071277(N-(4-{2-[(S)-2-Hydroxy-3-(pyridin-3-yloxy)-propyla...)
Affinity DataEC50:  32nMAssay Description:Evaluated for its agonist activity against human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090162(4-[2-(3,4-Difluoro-phenyl)-oxazol-5-yl]-N-{(R)-4-[...)
Affinity DataEC50:  35nMAssay Description:In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071296(N-(4-{2-[(S)-3-(6-Amino-pyridin-3-yloxy)-2-hydroxy...)
Affinity DataEC50:  7.80nMAssay Description:Evaluated for its agonist activity against human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50092024(N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-...)
Affinity DataEC50:  14nMAssay Description:Tested in vitro for its ability to stimulate increase in cAMP in CHO cells expressing the cloned human beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50092028(N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-...)
Affinity DataEC50:  3.10nMAssay Description:Tested in vitro for its ability to stimulate increase in cAMP in CHO cells expressing the cloned human beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070164([4-(4-{2-[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-prop...)
Affinity DataEC50:  1nMAssay Description:Agonist activity towards human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071291(N-{4-[2-((S)-2-Hydroxy-3-phenoxy-propylamino)-ethy...)
Affinity DataEC50:  120nMAssay Description:Evaluated for its agonist activity against human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071276(N-(4-{2-[(S)-3-(6-Amino-pyridin-3-yloxy)-2-hydroxy...)
Affinity DataEC50:  43nMAssay Description:Evaluated for its agonist activity against human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070152(N-(4-{2-[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propy...)
Affinity DataEC50:  1.60nMAssay Description:Evaluated for its agonist activity against human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075883(4-(3-Hexyl-4-methyl-2-oxo-2,3-dihydro-imidazol-1-y...)
Affinity DataEC50:  81nMAssay Description:Agonist activity towards Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50092035(4-[4-(4-Fluoro-benzoyl)-[1,2,3]triazol-2-yl]-N-{4-...)
Affinity DataEC50:  6.40nMAssay Description:Tested in vitro for its ability to stimulate increase in cAMP in CHO cells expressing the cloned human beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090168(4-[2-((R)-4,4-Dimethyl-pentyl)-oxazol-5-yl]-N-{4-[...)
Affinity DataEC50:  230nMAssay Description:In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50092030(4-{4-[(4-Fluoro-phenyl)-hydroxy-methyl]-[1,2,3]tri...)
Affinity DataEC50:  3.30nMAssay Description:Tested in vitro for its ability to stimulate increase in cAMP in CHO cells expressing the cloned human beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50092027(N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-...)
Affinity DataEC50:  14nMAssay Description:Tested in vitro for its ability to stimulate increase in cAMP in CHO cells expressing the cloned human beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070171(N-(4-{2-[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propy...)
Affinity DataEC50:  1nMAssay Description:Agonist activity towards human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070167(4-(3-Heptyl-ureido)-N-(4-{2-[(S)-2-hydroxy-3-(4-hy...)
Affinity DataEC50:  2.80nMAssay Description:Agonist activity towards human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070159(N-(4-{2-[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propy...)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity towards human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071297(Quinoline-3-sulfonic acid (4-{2-[(S)-2-hydroxy-3-(...)
Affinity DataEC50:  32nMAssay Description:Evaluated for its agonist activity against human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070161(N-(4-{2-[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propy...)
Affinity DataEC50:  5.20nMAssay Description:Agonist activity towards human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071283(N-(4-{2-[(S)-3-(6-Amino-pyridin-3-yloxy)-2-hydroxy...)
Affinity DataEC50:  26nMAssay Description:Evaluated for Adenylyl cyclase activation as % of the maximal stimulation with isoproterenol at 100 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070156((S)-4-(3-hexylureido)-N-(4-(2-(1-hydroxy-2-(4-hydr...)
Affinity DataEC50:  0.430nMAssay Description:Evaluated for its agonist activity against human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071299(4-Fluoro-N-(4-{2-[(S)-2-hydroxy-3-(pyridin-3-yloxy...)
Affinity DataEC50:  18nMAssay Description:Evaluated for Adenylyl cyclase activation as % of the maximal stimulation with isoproterenol at 100 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071294(N-(4-{2-[(S)-2-Hydroxy-3-(pyridin-3-yloxy)-propyla...)
Affinity DataEC50:  3.60nMAssay Description:Evaluated for its agonist activity against human Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075897(N-{4-[2-(2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethy...)
Affinity DataEC50:  2.20nMAssay Description:Agonist activity towards Beta-3 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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