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TargetBeta-secretase 1(Human)
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50360215(CHEMBL1927635)
Affinity DataIC50: 46nMAssay Description:Inhibition of human recombinant BACE1 ectodomain (1 to 460 amino acids) assessed as inhibition of proteolytic cleavage of Rhodamine-EVNLDAEFK-Quenche...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50360214(CHEMBL1927636)
Affinity DataIC50: 165nMAssay Description:Inhibition of human recombinant BACE1 ectodomain (1 to 460 amino acids) assessed as inhibition of proteolytic cleavage of Rhodamine-EVNLDAEFK-Quenche...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555366(CHEMBL4747214)
Affinity DataIC50: 500nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555369(CHEMBL4740960)
Affinity DataIC50: 700nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555364(CHEMBL4761666)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555365(CHEMBL4751920)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10 | ...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555368(CHEMBL4794107)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555372(CHEMBL4744317)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555365(CHEMBL4751920)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10 | ...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of N-terminal His6-tagged mouse DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rat)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10 | ...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of N-terminal His6-tagged rat DHODH expressed in Escherichia coli BL21 expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555365(CHEMBL4751920)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555368(CHEMBL4794107)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555366(CHEMBL4747214)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555364(CHEMBL4761666)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: 1.69E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555366(CHEMBL4747214)
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555364(CHEMBL4761666)
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555368(CHEMBL4794107)
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555366(CHEMBL4747214)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555364(CHEMBL4761666)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555365(CHEMBL4751920)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555366(CHEMBL4747214)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555368(CHEMBL4794107)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555364(CHEMBL4761666)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using isoform-specific probe substrate in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555365(CHEMBL4751920)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using isoform-specific probe substrate in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555366(CHEMBL4747214)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using isoform-specific probe substrate in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using isoform-specific probe substrate in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555368(CHEMBL4794107)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using isoform-specific probe substrate in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555365(CHEMBL4751920)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555368(CHEMBL4794107)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555364(CHEMBL4761666)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555365(CHEMBL4751920)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555364(CHEMBL4761666)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555366(CHEMBL4747214)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555364(CHEMBL4761666)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555365(CHEMBL4751920)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555366(CHEMBL4747214)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50555368(CHEMBL4794107)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50365224(CHEMBL1956291 | US9238653, Table 5, Compound 29)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50555375(CHEMBL4750037)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of N-terminal His6-tagged human DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged human DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50555369(CHEMBL4740960)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged human DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
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