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TargetAmine oxidase [flavin-containing] A(Rat)
Babu Banarasi Das Northern India Institute of Technology

Curated by ChEMBL
LigandPNGBDBM174835(US9114126, 2027BA1)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of rat MAO-AMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50203332(CHEMBL3913908)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM103302(SCH772984 | US8546404, 6)
Affinity DataIC50: 0.800nMAssay Description:Activated ERK2 activity was determined in the IMAP assay format.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50274157(CHEMBL4127656)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50274165(CHEMBL4126996)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ERK2 (unknown origin) using peptide substrate measured after 45 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ERK2 (unknown origin) preincubated for 45 mins followed by substrate addition measured after 0.5 hrs by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50458811(CHEMBL4209570)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of ERK2 (unknown origin) using peptide substrate measured after 45 mins by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50274156(CHEMBL4128368)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579208(CHEMBL4867107)
Affinity DataIC50: 2nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Babu Banarasi Das Northern India Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50029810(2-[5-(4-Benzyloxy-phenyl)-tetrazol-2-yl]-ethanol |...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human MAO-BMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Babu Banarasi Das Northern India Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50029819(2-{5-[4-(3-Chloro-benzyloxy)-phenyl]-tetrazol-2-yl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human MAO-BMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM188933(US9169260, 200 | US9169260, 199)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full length human IRAK4 expressed in baculovirus-infected insect Sf9 cells using 5FAM-RKRQGSVRRRVH-CO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM103295(US8546404, 462)
Affinity DataIC50: 2.10nMAssay Description:Activated ERK2 activity was determined in the IMAP assay format.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM103295(US8546404, 462)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579222(CHEMBL4861383)
Affinity DataIC50: 2.30nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM518526(US11124518, Example 1 | 2-Allyl-1-(6-(2-hydroxypro...)
Affinity DataIC50: 2.40nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM518531(US11124518, Example 6 | 2-Allyl-1-(6-(2-hydroxypro...)
Affinity DataIC50: 2.40nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM518527(US11124518, Example 2 | 2-Alyl-6-((2′,3̸...)
Affinity DataIC50: 2.40nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM34531(US8546404, 459)
Affinity DataIC50: 2.5nMAssay Description:Activated ERK2 activity was determined in the IMAP assay format.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM103292(US8546404, 1729 | US8546404, 469)
Affinity DataIC50: 2.5nMAssay Description:Activated ERK2 activity was determined in the IMAP assay format.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM103292(US8546404, 1729 | US8546404, 469)
Affinity DataIC50: 2.5nMAssay Description:Activated ERK2 activity was determined in the IMAP assay format.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM518538(US11124518, Example 13 | 2-Allyl-6-((2-(2-hydroxye...)
Affinity DataIC50: 2.5nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579228(CHEMBL4867211)
Affinity DataIC50: 2.5nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM518530(US11124518, Example 5 | 2-Allyl-1-(6-(2-hydroxypro...)
Affinity DataIC50: 2.60nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM518540(US11124518, Example 16 | 2-Allyl-1-(6-(2-hydroxypr...)
Affinity DataIC50: 2.60nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579214(CHEMBL4856035)
Affinity DataIC50: 2.60nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579225(CHEMBL4874546)
Affinity DataIC50: 2.60nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579218(CHEMBL4876612)
Affinity DataIC50: 2.90nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579223(CHEMBL4853285)
Affinity DataIC50: 3.10nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579221(CHEMBL4866800)
Affinity DataIC50: 3.20nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579224(CHEMBL4861351)
Affinity DataIC50: 3.20nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579227(CHEMBL4847705)
Affinity DataIC50: 3.20nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579216(CHEMBL4865963)
Affinity DataIC50: 3.30nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579213(CHEMBL4853973)
Affinity DataIC50: 3.60nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579219(CHEMBL4857841)
Affinity DataIC50: 3.70nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579220(CHEMBL4868683)
Affinity DataIC50: 3.70nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50203339(CHEMBL3922888)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50240826(AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...)
Affinity DataIC50: 3.90nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579217(CHEMBL4871593)
Affinity DataIC50: 3.90nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Banasthali University

Curated by ChEMBL
LigandPNGBDBM50059061((6aR,9aS)-5,6a,7,8,9,9a-Hexahydro-5-methyl-2-(phen...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50274164(CHEMBL4129721)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579215(CHEMBL4861168)
Affinity DataIC50: 4.60nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM103293(US8546404, 480)
Affinity DataIC50: 4.80nMAssay Description:Activated ERK2 activity was determined in the IMAP assay format.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM103293(US8546404, 480)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579211(CHEMBL4871803)
Affinity DataIC50: 4.80nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM103296(US8546404, 622)
Affinity DataIC50: 5nMAssay Description:Activated ERK2 activity was determined in the IMAP assay format.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50274147(CHEMBL4129859)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM330383(US9725436, Entry 3)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM330384(US9725436, Entry 4)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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