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TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKd:  37nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502159(2-chloro-N- [4-(1- methyl- [1,2,4[tria zolo[4,3- a...)
Affinity DataKd:  32nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataKd:  5.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50643330(CHEMBL5573286)
Affinity DataKd: >5.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50643330(CHEMBL5573286)
Affinity DataKd: >5.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataKd:  5.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50643326(CHEMBL5591787)
Affinity DataKd:  900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKd:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Mouse)
Monash University

Curated by ChEMBL
LigandPNGBDBM50602486(CHEMBL5196154)
Affinity DataKd:  20nMAssay Description:Binding affinity to MERTK in cuprizone-challenged C57BL/6 mouse brain CC/HC region assessed as dissociation constant at 18.1 nM by autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetForkhead box protein O3(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50349826(SYRINGARESINOL)
Affinity DataKd:  1.73E+6nMAssay Description:Binding affinity to His-tagged FOXO3a (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50337787((R)-2-(4-(((S)-3-((R)-3-amino-4-(2,4,5-trifluoroph...)
Affinity DataEC50:  4.08E+5nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetTranslocator protein(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataKd:  11nMAssay Description:Binding affinity to C-terminal DDK-tagged human recombinant full-length TSPO expressed in HEK293 cells by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502158(N-[4-(1- methyl- [1,2,4]tria zolo[4,3- a]quinoxali...)
Affinity DataKd:  29nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataKd:  14nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50564363(CHEMBL4791998)
Affinity DataKd: <0.25nMAssay Description:Binding affinity to human FLT3 ITD mutant in presence of ATP by Lanthascreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50593961(CHEMBL5195819)
Affinity DataKd:  0.0154nMAssay Description:Binding affinity to FLT3 ITD/F691L double mutant (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50349826(SYRINGARESINOL)
Affinity DataEC50:  1.81E+4nMAssay Description:Activation of PPARbeta-LBD (unknown origin) assessed as fluorescein-labeled coactivator C33 recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50643327(CHEMBL5567633)
Affinity DataKd:  2.20E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataKd:  293nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataKd:  6.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502150(US11028090, Example 1)
Affinity DataKd:  190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50643328(CHEMBL5575153)
Affinity DataKd:  260nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50643326(CHEMBL5591787)
Affinity DataKd:  510nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTranslocator protein(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50279019(CHEMBL1315992)
Affinity DataKd:  40nMAssay Description:Binding affinity to C-terminal DDK-tagged human recombinant full-length TSPO expressed in HEK293 cells by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502312(US11028090, Example 200)
Affinity DataKd:  220nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50349826(SYRINGARESINOL)
Affinity DataKd:  2.76E+4nMAssay Description:Binding affinity to recombinant PPARbeta-LBD (254 to 441 residues) (unknown origin) expressed in Escherichia coli Rosetta2 cells by isothermal titrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502150(US11028090, Example 1)
Affinity DataKd:  40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50643329(CHEMBL5573851)
Affinity DataKd: >5.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50643329(CHEMBL5573851)
Affinity DataKd: >5.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Mouse)
Monash University

Curated by ChEMBL
LigandPNGBDBM50602486(CHEMBL5196154)
Affinity DataKd:  13nMAssay Description:Binding affinity to MERTK in cuprizone-challenged C57BL/6 mouse whole brain assessed as dissociation constant at 18.1 nM by autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502312(US11028090, Example 200)
Affinity DataKd:  36nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50643327(CHEMBL5567633)
Affinity DataKd:  1.30E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTranslocator protein(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50279015(CHEMBL4174207)
Affinity DataKd:  61nMAssay Description:Binding affinity to C-terminal DDK-tagged human recombinant full-length TSPO expressed in HEK293 cells by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50127222({4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl...)
Affinity DataEC50:  67nMAssay Description:Activation of PPARbeta-LBD (unknown origin) assessed as fluorescein-labeled coactivator C33 recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502158(N-[4-(1- methyl- [1,2,4]tria zolo[4,3- a]quinoxali...)
Affinity DataKd:  180nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50643328(CHEMBL5575153)
Affinity DataKd:  630nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502159(2-chloro-N- [4-(1- methyl- [1,2,4[tria zolo[4,3- a...)
Affinity DataKd:  110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50546288(CHEMBL4743437)
Affinity DataIC50: 0.00270nMAssay Description:Inhibition of CD73 in human CD8-positive T cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527134(CHEMBL4471306 | US20230295213, Compound a)
Affinity DataIC50: 0.00800nMAssay Description:Inhibition of CD73 in human CD8-positive T cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50546288(CHEMBL4743437)
Affinity DataIC50: 0.00850nMAssay Description:Inhibition of CD73 in human PBMC using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 2.5 hrs by PiColor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50546280(CHEMBL4761506)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of CD73 in human CD8-positive T cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527134(CHEMBL4471306 | US20230295213, Compound a)
Affinity DataIC50: 0.0110nMAssay Description:Inhibition of CD73 in human PBMC using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 2.5 hrs by PiColor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50546280(CHEMBL4761506)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of CD73 in human PBMC using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 2.5 hrs by PiColor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50546290(CHEMBL4749428)
Affinity DataIC50: 0.0270nMAssay Description:Inhibition of human CD73 expressed in CHO cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50546285(CHEMBL4776758)
Affinity DataIC50: 0.0280nMAssay Description:Inhibition of human CD73 expressed in CHO cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50546284(CHEMBL4740465)
Affinity DataIC50: 0.0310nMAssay Description:Inhibition of human CD73 expressed in CHO cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50546281(CHEMBL4746184)
Affinity DataIC50: 0.0310nMAssay Description:Inhibition of human CD73 expressed in CHO cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50546283(CHEMBL4797225)
Affinity DataIC50: 0.0320nMAssay Description:Inhibition of human CD73 expressed in CHO cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527134(CHEMBL4471306 | US20230295213, Compound a)
Affinity DataIC50: 0.0410nMAssay Description:Inhibition of human CD73 expressed in CHO cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527134(CHEMBL4471306 | US20230295213, Compound a)
Affinity DataIC50: 0.0430nMAssay Description:Inhibition of soluble human CD73More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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