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TargetIntegrin alpha-L(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324825((R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-met...)
Affinity DataKd:  26nMAssay Description:Binding affinity to LFA1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333919((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324826((2S)-2-(2,6-dichloro-4-(3-hydroxy-3-(3-hydroxyphen...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of LFA1 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333915((S)-2-(2-(benzofuran-2-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324822((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324824((S)-2-(2-(benzofuran-2-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333917((S)-2-(5,7-dichloro-2-(pyrazolo[1,5-a]pyridine-2-c...)
Affinity DataIC50: 7nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324822((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 9nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324810((S)-2-(5,7-dichloro-2-(4-methylbenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 10nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324823((S)-2-(5,7-dichloro-2-(2,3-dihydrobenzofuran-6-car...)
Affinity DataIC50: 13nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM151585(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Affinity DataIC50: 15nMAssay Description:Inhibition of CYP3A4 using in human liver microsomes using testosterone as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A4(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM151585(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Affinity DataIC50: 18nMAssay Description:Inhibition of CYP3A4 using in human liver microsomes using midazolam as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333916((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 19nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324812((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 22nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324812((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 22nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324806((S,E)-2-(5,7-dichloro-2-(3-(furan-2-yl)acryloyl)-1...)
Affinity DataIC50: 25nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333904((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 26nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324816((S)-3-benzamido-2-(5,7-dichloro-2-(4-chlorobenzoyl...)
Affinity DataIC50: 29nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333918((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 30nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 35nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333905((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 39nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092956(A-286982 | 1-(4-acetylpiperazin-1-yl)-3-(4-(2-isop...)
Affinity DataIC50: 44nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324817((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 51nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333911((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 59nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324811((S)-2-(5,7-dichloro-2-(3-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 66nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324824((S)-2-(2-(benzofuran-2-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 69nMAssay Description:Inhibition of LFA1-mediated Staphylococcal enterotoxin B-stimulated human T cell activation in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324807((S)-2-(2-benzoyl-5,7-dichloro-1,2,3,4-tetrahydrois...)
Affinity DataIC50: 79nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324809((S)-2-(5,7-dichloro-2-(3-methylbenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 90nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333919((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 96nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333901((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 100nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333906((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 140nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333921((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 150nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333909((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 170nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333915((S)-2-(2-(benzofuran-2-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 190nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50090677(CHEMBL1109 | 4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-...)
Affinity DataIC50: 205nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324811((S)-2-(5,7-dichloro-2-(3-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 240nMAssay Description:Inhibition of LFA1-mediated Staphylococcal enterotoxin B-stimulated human T cell activation in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333913((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 250nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333917((S)-2-(5,7-dichloro-2-(pyrazolo[1,5-a]pyridine-2-c...)
Affinity DataIC50: 260nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324822((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 260nMAssay Description:Inhibition of LFA1-mediated Staphylococcal enterotoxin B-stimulated human T cell activation in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333912((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 310nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333907((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 430nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324812((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 430nMAssay Description:Inhibition of LFA1-mediated Staphylococcal enterotoxin B-stimulated human T cell activation in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324808((S)-2-(5,7-dichloro-2-(2-methylbenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 460nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324815((S)-3-(cyclohexanecarboxamido)-2-(5,7-dichloro-2-(...)
Affinity DataIC50: 540nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324816((S)-3-benzamido-2-(5,7-dichloro-2-(4-chlorobenzoyl...)
Affinity DataIC50: 550nMAssay Description:Inhibition of LFA1-mediated Staphylococcal enterotoxin B-stimulated human T cell activation in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333918((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 560nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333908((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)
Affinity DataIC50: 560nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324814((S)-3-acetamido-2-(5,7-dichloro-2-(4-chlorobenzoyl...)
Affinity DataIC50: 620nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324823((S)-2-(5,7-dichloro-2-(2,3-dihydrobenzofuran-6-car...)
Affinity DataIC50: 650nMAssay Description:Inhibition of LFA1-mediated Staphylococcal enterotoxin B-stimulated human T cell activation in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50125195((S)-2-(2-Bromo-benzoylamino)-3-(3H-imidazol-4-yl)-...)
Affinity DataIC50: 750nMAssay Description:Inhibition of LFA1/ICAM1 interaction by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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