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TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273322(CHEMBL4130251)
Affinity DataEC50:  190nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273328(CHEMBL4128618)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273344(CHEMBL4128888)
Affinity DataEC50:  560nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273345(CHEMBL4129988)
Affinity DataEC50:  540nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273346(CHEMBL4127369)
Affinity DataEC50:  400nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273349(CHEMBL4127519)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273329(CHEMBL4127375)
Affinity DataEC50:  450nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273330(CHEMBL4128769)
Affinity DataEC50:  230nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273373(CHEMBL4129385)
Affinity DataEC50:  210nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273324(CHEMBL1520947)
Affinity DataEC50:  5.40E+3nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273325(CHEMBL4127958)
Affinity DataEC50:  9.20E+3nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273327(CHEMBL4128693)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50035558(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Affinity DataKd:  1.35E+4nMAssay Description:Binding affinity to his-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50035558(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627130(CHEMBL5417380)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627131(CHEMBL5413392)
Affinity DataKd:  4.10E+4nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627132(CHEMBL5397755)
Affinity DataKd: >5.00E+4nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627133(CHEMBL5430500)
Affinity DataKd:  1.14E+4nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627134(CHEMBL5424418)
Affinity DataKd:  2.67E+4nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627135(CHEMBL5409735)
Affinity DataKd:  5.60E+3nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627136(CHEMBL5424590)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627137(CHEMBL5439774)
Affinity DataKd:  98nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627138(CHEMBL5397181)
Affinity DataKd:  47nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627139(CHEMBL5431028)
Affinity DataKd:  83nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627140(CHEMBL5429394)
Affinity DataKd:  31nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50035558(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1039 to 1401 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627130(CHEMBL5417380)
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1039 to 1401 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627141(CHEMBL5403546)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1039 to 1401 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627131(CHEMBL5413392)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1039 to 1401 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627141(CHEMBL5403546)
Affinity DataKd:  2.10E+4nMAssay Description:Binding affinity to his-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using H3K27me3 as substrate assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627131(CHEMBL5413392)
Affinity DataKd:  2.50E+4nMAssay Description:Binding affinity to his-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using H3K27me3 as substrate assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50549337(CHEMBL4748505)
Affinity DataIC50: 2nMAssay Description:Allosteric inhibition of human wild-type full-length MALT1 (329 to 824 residues) protease activity using Ac-Leu-Arg-Ser-Arg Rh110-dPro as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50549341(CHEMBL4757361)
Affinity DataIC50: 2nMAssay Description:Allosteric inhibition of human wild-type full-length MALT1 (329 to 824 residues) protease activity using Ac-Leu-Arg-Ser-Arg Rh110-dPro as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM355897(US9815842, Example 21 | 1-(5-chloro-6-(2H- 1,2,3-t...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM355921(US9815842, Example 45 | (R)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315236((4-(8-(3,5-difluoro-4-(morpholinomethyl)phenyl)qui...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant GST tagged JAK2 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273330(CHEMBL4128769)
Affinity DataIC50: 4nMAssay Description:Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg'Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM355920(US9815842, Example 44 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM355878((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315237(4-(2,6-difluoro-4-(3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of recombinant GST tagged JAK2 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50549339(CHEMBL4796575)
Affinity DataIC50: 5nMAssay Description:Allosteric inhibition of human wild-type full-length MALT1 (329 to 824 residues) protease activity using Ac-Leu-Arg-Ser-Arg Rh110-dPro as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM355928(US9815842, Example 52 | 1-(4-chloro-6-(2H- 1,2,3-t...)
Affinity DataIC50: 5nMAssay Description:Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50312980(N-(4-(2-(3,4,5-trimethoxyphenylamino)benzo[d]oxazo...)
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged JAK2 assessed as inhibition of biotinylated JAK3tide peptide phosphorylation after 60 mins by caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50312986(4-(7-(3,5-difluoro-4-(morpholinomethyl)phenyl)benz...)
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged JAK2 assessed as inhibition of biotinylated JAK3tide peptide phosphorylation after 60 mins by caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50312987(4-(7-(3,5-difluoro-4-(morpholinomethyl)phenyl)benz...)
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged JAK2 assessed as inhibition of biotinylated JAK3tide peptide phosphorylation after 60 mins by caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50312989(4-(7-(3,5-difluoro-4-(morpholinomethyl)phenyl)benz...)
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged JAK2 assessed as inhibition of biotinylated JAK3tide peptide phosphorylation after 60 mins by caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315240(1-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-2-{4-[...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of recombinant GST tagged JAK2 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50549338(CHEMBL4765158)
Affinity DataIC50: 6nMAssay Description:Allosteric inhibition of human wild-type full-length MALT1 (329 to 824 residues) protease activity using Ac-Leu-Arg-Ser-Arg Rh110-dPro as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50549342(CHEMBL4795909)
Affinity DataIC50: 6nMAssay Description:Allosteric inhibition of human wild-type full-length MALT1 (329 to 824 residues) protease activity using Ac-Leu-Arg-Ser-Arg Rh110-dPro as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
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