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TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

LigandPNGBDBM9914(3-[(R)-1H-imidazol-1-yl(4-nitrophenyl)methyl]-4H-c...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

LigandPNGBDBM9915(3-[(S)-1H-imidazol-1-yl(4-nitrophenyl)methyl]-4H-c...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

LigandPNGBDBM9916(CHEMBL522917 | 3-[(R)-(4-bromophenyl)(1H-imidazol-...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

LigandPNGBDBM9917(3-[(S)-(4-bromophenyl)(1H-imidazol-1-yl)methyl]-4H...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

LigandPNGBDBM9918(CHEMBL225079 | 4-[(R)-1H-imidazol-1-yl(4-oxo-4H-ch...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

LigandPNGBDBM9919(CHEMBL451201 | 4-[(S)-1H-imidazol-1-yl(4-oxo-4H-ch...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

LigandPNGBDBM9920(CHEMBL31215 | 4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]py...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Consiglio Nazionale Delle Ricerche (Icrm-Cnr)

Curated by ChEMBL
LigandPNGBDBM50564049(CHEMBL4785109)
Affinity DataEC50:  23nMAssay Description:Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Consiglio Nazionale Delle Ricerche (Icrm-Cnr)

Curated by ChEMBL
LigandPNGBDBM50236333(CHEMBL4092052)
Affinity DataEC50:  1nMAssay Description:Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Consiglio Nazionale Delle Ricerche (Icrm-Cnr)

Curated by ChEMBL
LigandPNGBDBM50564050(CHEMBL4117318)
Affinity DataEC50:  18nMAssay Description:Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Consiglio Nazionale Delle Ricerche (Icrm-Cnr)

Curated by ChEMBL
LigandPNGBDBM50236352(CHEMBL4090581)
Affinity DataEC50:  3.60nMAssay Description:Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Consiglio Nazionale Delle Ricerche (Icrm-Cnr)

Curated by ChEMBL
LigandPNGBDBM50236342(CHEMBL4065510)
Affinity DataEC50:  38nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50624187(CHEMBL5406715)
Affinity DataEC50:  1.20E+3nMAssay Description:Corrector activity at CFTR F508del mutant in human CFBE41o- cells coexpressing HS-YFP incubated for 25 mins by microplate reader based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50624188(CHEMBL5429527)
Affinity DataEC50:  1.60E+3nMAssay Description:Corrector activity at CFTR F508del mutant in human CFBE41o- cells coexpressing HS-YFP incubated for 25 mins by microplate reader based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50624189(CHEMBL5395987)
Affinity DataEC50:  2.60E+3nMAssay Description:Corrector activity at CFTR F508del mutant in human CFBE41o- cells incubated for 25 mins by microplate reader based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218506(3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimeth...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218521(3-{3-[(benzylethylamino)-methyl]-phenyl}-6,7-dimet...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218525(6,7-dimethoxy-3-(4-{[(4-methoxybenzyl)methylamino]...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218504(3-{3-[(benzylmethylamino)methyl]phenyl}-6,7-dimeth...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218507(6,7-dimethoxy-3-(4-{[(3-nitrobenzyl)methylamino]me...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218508(6,7-dimethoxy-3-(4-{[(3-methoxybenzyl)methylamino]...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218522(6-amino-3-{4-[(benzylmethylamino)methyl]phenyl}-ch...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218519(6,7-dimethoxy-3-(4-{[(2-nitrobenzyl)methylamino]me...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218511(6,7-dimethoxy-3-(4-{[(4-nitrobenzyl)methylamino]me...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218524(6-[(benzylmethylamino)methyl]-2,3-dimethoxyxanthen...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218529(6,7-dimethoxy-3-(4-{[(4-methylbenzyl)methylamino]m...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218526(6,7-dimethoxy-3-(4-{[(3-methylbenzyl)methylamino]m...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218516(6,7-dimethoxy-3-(4-{[(2-methylbenzyl)methylamino]m...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218523(2-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimeth...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218503(3-{3-[(benzylmethylamino)methyl]phenyl}-7-methoxyc...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218514(2-{4-[(benzylmethylamino)methyl]phenyl}-7-methoxyc...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218510(3-{4-[(benzylmethylamino)methyl]phenyl}-6-nitrochr...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218509(2-{3-[(benzylmethylamino)methyl]phenyl}-6,7-dimeth...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM9012(7-[(6,8-dichloro-1,2,3,4-tetrahydroacridin-9-yl)am...)
Affinity DataIC50: 0.00800nMAssay Description:Inhibition of human AchEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM9022(N-[5-(6-Chloro-1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human AchEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM9023(N-{7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)ami...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human AchEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10512(CHEMBL194823 | N-{3-[(6-chloro-1,2,3,4-tetrahydroa...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human AchEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10692(3-{[methyl({3-[(9-oxo-9H-xanthen-3-yl)oxy]propyl})...)
Affinity DataIC50: 0.300nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10692(3-{[methyl({3-[(9-oxo-9H-xanthen-3-yl)oxy]propyl})...)
Affinity DataIC50: 0.300nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10692(3-{[methyl({3-[(9-oxo-9H-xanthen-3-yl)oxy]propyl})...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human erythrocyte AchEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10692(3-{[methyl({3-[(9-oxo-9H-xanthen-3-yl)oxy]propyl})...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human AchEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10693(CHEMBL189957 | 3-{[methyl({7-[(9-oxo-9H-xanthen-3-...)
Affinity DataIC50: 0.320nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10693(CHEMBL189957 | 3-{[methyl({7-[(9-oxo-9H-xanthen-3-...)
Affinity DataIC50: 0.320nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10693(CHEMBL189957 | 3-{[methyl({7-[(9-oxo-9H-xanthen-3-...)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human erythrocyte AchEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50275723(2,7-bis(6-(ethyl(2-methoxybenzyl)amino)hexyl)benzo...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of human recombinant AChE by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10697(3-{[methyl(7-{[(2Z)-3-oxo-2-(3,4,5-trimethoxybenzy...)
Affinity DataIC50: 0.520nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10932(3-{[ethyl({3-[(9-oxo-9H-xanthen-3-yl)oxy]propyl})a...)
Affinity DataIC50: 0.560nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10938(3-[({3-[(9-oxo-9H-xanthen-3-yl)oxy]propyl}(propan-...)
Affinity DataIC50: 0.700nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 0.810nMAssay Description:Inhibition of human serum recombinant AChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10913(3-{[methyl({5-[(9-oxo-9H-xanthen-3-yl)oxy]pentyl})...)
Affinity DataIC50: 0.820nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2006
Entry Details Article
PubMed
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