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TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585527(CHEMBL5084861)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  0.251nMAssay Description:Binding affinity to PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585527(CHEMBL5084861)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585519(CHEMBL5075556)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585519(CHEMBL5075556)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585505(CHEMBL5078647)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585507(CHEMBL5078141)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585527(CHEMBL5084861)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585519(CHEMBL5075556)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585501(CHEMBL5084542)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585505(CHEMBL5078647)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585505(CHEMBL5078647)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50506311(CHEMBL4462123)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585501(CHEMBL5084542)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585501(CHEMBL5084542)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585509(CHEMBL5085176)
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585502(CHEMBL5082928)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585504(CHEMBL5084340)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585507(CHEMBL5078141)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585508(CHEMBL5079248)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50506329(CHEMBL4518946)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585507(CHEMBL5078141)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585509(CHEMBL5085176)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585510(CHEMBL5076068)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50506332(CHEMBL4561242)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of VPS34 in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585511(CHEMBL5077126)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50506329(CHEMBL4518946)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585518(CHEMBL5094089)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585506(CHEMBL5074310)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585509(CHEMBL5085176)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  2nMAssay Description:Binding affinity to VPS34 in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585513(CHEMBL5087255)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585508(CHEMBL5079248)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50506325(CHEMBL4567736)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585508(CHEMBL5079248)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585512(CHEMBL5075223)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585500(CHEMBL5077653)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585517(CHEMBL5076101)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585506(CHEMBL5074310)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50506346(CHEMBL4436659)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50506328(CHEMBL4447804)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
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