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TargetCalcitonin gene-related peptide type 1 receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [I125]CGRP from human CGRP receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50268484((R)-N-(1-(1,4'-bipiperidin-1'-yl)-3-(7-methyl-1H-i...)
Affinity DataKi:  0.0128nMAssay Description:Displacement of [I125]CGRP from human CGRP receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50240440(CHEMBL285718 | 4-P-PDOT | N-(4-Phenyl-1,2,3,4-tetr...)
Affinity DataKi:  0.0158nMAssay Description:Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM340336(US9758538, Example 24)
Affinity DataKi: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007522(CHEMBL289330 | 5-Bromo-N-(1-ethyl-pyrrolidin-2-ylm...)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
LigandPNGBDBM207378(US9260439, 262)
Affinity DataKi: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM207196(US9260439, 173)
Affinity DataKi: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM207217(US9260439, 238 | US9260439, 239 | US9260439, 194)
Affinity DataKi: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM340314(US9758538, Example 2 | (Scheme A): Preparation of ...)
Affinity DataKi: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM340384(US9758538, Example 72)
Affinity DataKi: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM340346(US9758538, Example 34)
Affinity DataKi:  0.0190nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM340391(US9758538, Example 79)
Affinity DataKi:  0.0210nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50368060(CHEMBL1907695)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM207028(US9260439, 10 | US9260439, 4)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM207236(US9260439, 213)
Affinity DataKi: <0.0230nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50527938(CHEMBL4454033)
Affinity DataKd:  0.0230nMAssay Description:Binding affinity to human PI5P4IKgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007508(CHEMBL176458 | (R) N-(1-Benzyl-pyrrolidin-2-ylmeth...)
Affinity DataKi:  0.0240nMAssay Description:Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
LigandPNGBDBM207172(US9260439, 149)
Affinity DataKi: <0.0290nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM207391(US9260439, 275)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50368067(CHEMBL1907702)
Affinity DataKi:  0.0330nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50268484((R)-N-(1-(1,4'-bipiperidin-1'-yl)-3-(7-methyl-1H-i...)
Affinity DataEC50:  0.0345nMAssay Description:Antagonist activity at human CGRP receptor in SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA polymerase theta(Human)
Repare Therapeutics

US Patent
LigandPNGBDBM715306(US20250026748, Compound 470)
Affinity DataIC50: 0.0490nMAssay Description:PolQ ATPase enzyme (1-894) at 0.5 nM is incubated with a 10-point concentration response of inhibitors for 15 min at rt in the following buffer: 50 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Rat)
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007517(CHEMBL76402 | 3-Bromo-N-(1-ethyl-pyrrolidin-2-ylme...)
Affinity DataKi:  0.0640nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007517(CHEMBL76402 | 3-Bromo-N-(1-ethyl-pyrrolidin-2-ylme...)
Affinity DataKi:  0.0640nMAssay Description:Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetSomatostatin receptor type 2(Mouse)
University of Chicago

Curated by PDSP Ki Database
LigandPNGBDBM81766(CAS_3086456 | NSC_3086456 | MK 678)
Affinity DataKi:  0.0700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
LigandPNGBDBM50632513(CHEMBL5415661)
Affinity DataKi: <0.0700nMAssay Description:Inhibition of full length human recombinant HPK1 expressed in baculovirus-infected insect cells using 5-FAM-KRRALSSLRA-COOH peptide as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM207234(US9260439, 211)
Affinity DataKi:  0.0780nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor A/B(Rat)
Hoechst Roussel Pgu Cardiovascular Agents

Curated by ChEMBL
LigandPNGBDBM50470233(CHEMBL80177)
Affinity DataIC50: 0.0800nMAssay Description:Specific binding inhibition of [125I]AII to Angiotensin II receptor, type 1 in rat liver membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetSomatostatin receptor type 2(Mouse)
University of Chicago

Curated by PDSP Ki Database
LigandPNGBDBM81767(15-28-Somatostatin-28 | CB6417646 | CAS_38916-34-6...)
Affinity DataKi:  0.0800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
LigandPNGBDBM207239(US9260439, 216)
Affinity DataKi:  0.0840nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50368065(CHEMBL1907692)
Affinity DataKi:  0.0870nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor A/B(Rat)
Hoechst Roussel Pgu Cardiovascular Agents

Curated by ChEMBL
LigandPNGBDBM50470229(CHEMBL76870)
Affinity DataIC50: 0.0900nMAssay Description:Specific binding inhibition of [125I]AII to Angiotensin II receptor, type 1 in rat liver membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Uppsala University

LigandPNGBDBM854(CHEMBL127045 | N1,N6-Bis[(1S)-2-methyl-1-(methylca...)
Affinity DataKi:  0.0900nM ΔG°:  -58.3kJ/molepH: 5.0 T: 2°CAssay Description:Ki values were determined by using a fluorescent substrate (DABCYL-gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS). All incubations were performed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2004
Entry Details Article
PubMed
LigandPNGBDBM340352(US9758538, Example 40)
Affinity DataKi:  0.0950nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor A/B(Rat)
Hoechst Roussel Pgu Cardiovascular Agents

Curated by ChEMBL
LigandPNGBDBM50470236(CHEMBL309313)
Affinity DataIC50: 0.100nMAssay Description:Specific binding inhibition of [125I]AII to Angiotensin II receptor, type 1 in rat liver membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM50313793((S)-3-(3-amino-4-(3-(5,6,7,8-tetrahydro-1,8-naphth...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Integrin alpha5beta3 receptors expressed in HOP cells assessed as cell attachment after 30 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProtein kinase C delta type(Mouse)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057514(13-Hydroxymethyl-10-isopropyl-9-methyl-5-octyl-3,9...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]- PDBu from Protein kinase C delta C1b domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Uppsala University

LigandPNGBDBM12218((2R,3R,4R,5R)-N-benzyl-2,5-bis(benzyloxy)-3,4-dihy...)
Affinity DataKi:  0.100nM ΔG°:  -58.0kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2006
Entry Details Article
PubMed
TargetDNA polymerase theta(Human)
Repare Therapeutics

US Patent
LigandPNGBDBM715294(US20250026748, Compound 458)
Affinity DataIC50: 0.100nMAssay Description:PolQ ATPase enzyme (1-894) at 0.5 nM is incubated with a 10-point concentration response of inhibitors for 15 min at rt in the following buffer: 50 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetType-1 angiotensin II receptor A/B(Rat)
Hoechst Roussel Pgu Cardiovascular Agents

Curated by ChEMBL
LigandPNGBDBM50470239(CHEMBL311312)
Affinity DataIC50: 0.100nMAssay Description:Specific binding inhibition of [125I]AII to Angiotensin II receptor, type 1 in rat liver membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Uppsala University

LigandPNGBDBM851(N1,N6-Bis[(1S)-2-methyl-1-(methylcarbamoyl)propyl]...)
Affinity DataKi:  0.100nM ΔG°:  -58.0kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2006
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50246967(CHEMBL4080228 | US10570121, Example 81)
Affinity DataKi: <0.100nMAssay Description:Binding affinity to EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataKi:  0.110nMAssay Description:Reversible binding affinity to human EGFR L858R/ T790M double mutant expressed in baculovirus by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2017
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataKi:  0.120nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM207061(US9260439, 38)
Affinity DataKi:  0.120nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProtein kinase C delta type(Mouse)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099646(Ingenol-3-bezoate | 5,6-dihydroxy-7-hydroxymethyl-...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]PDBu from protein kinase C delta C1b domain (Wild type)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor(Rabbit)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM82372(NSC_3746 | CAS_22254-24-6 | Ipratropium)
Affinity DataKi:  0.130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50308250((1R,5R,6R)-1-(3,4-dichlorophenyl)-6-(ethoxymethyl)...)
Affinity DataKi:  0.135nMAssay Description:Displacement of [N-methyl-3H]nisoxetine from rat hippocampus NET by filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM340347(US9758538, Example 35)
Affinity DataKi:  0.140nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProtein kinase C delta type(Mouse)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099646(Ingenol-3-bezoate | 5,6-dihydroxy-7-hydroxymethyl-...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]PDBu from protein kinase C delta C1b domain mutant (F13G)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
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