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TargetGenome polyprotein [1658-1692](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Astex Pharmaceuticals

LigandPNGBDBM92630((3S)-N-(2-aminoethyl)-3-{[(1R)-1-(4-chloro-2-fluor...)
Affinity DataKd:  22nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Astex Pharmaceuticals

LigandPNGBDBM92631((3R)-3-{[(1S)-1-(4-chloro-2-fluoro-3-phenoxyphenyl...)
Affinity DataKd:  2.40E+4nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM304837(3-(7-methoxy-1-methyl-1H-1,2,3-benzotriazol-5-yl)-...)
Affinity DataEC50:  850nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50521640(CHEMBL4473977)
Affinity DataKd:  110nMAssay Description:Binding affinity to human N-terminal His6-tagged KEAP1 Kelch domain (321 to 609 residues) expressed in baculovirus infected Sf9 insect cells by isoth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50521640(CHEMBL4473977)
Affinity DataEC50:  3.40E+3nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM304768(3-(3-((1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5]o...)
Affinity DataEC50:  1.60E+3nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM304720(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
Affinity DataEC50:  1.40E+3nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM304721(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
Affinity DataEC50:  30nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM304727(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
Affinity DataEC50:  11nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM304837(3-(7-methoxy-1-methyl-1H-1,2,3-benzotriazol-5-yl)-...)
Affinity DataKd:  44nMAssay Description:Binding affinity to human N-terminal His6-tagged KEAP1 Kelch domain (321 to 609 residues) expressed in baculovirus infected Sf9 insect cells by isoth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM304414(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
Affinity DataEC50:  570nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM304728(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
Affinity DataEC50:  760nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM304768(3-(3-((1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5]o...)
Affinity DataKd:  35nMAssay Description:Binding affinity to human N-terminal His6-tagged KEAP1 Kelch domain (321 to 609 residues) expressed in baculovirus infected Sf9 insect cells by isoth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM304748(US10144731, Example 34a | BDBM304749)
Affinity DataEC50:  83nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM304770(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
Affinity DataEC50:  2.90E+3nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526485(CHEMBL4473072)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601801(CHEMBL5169432)
Affinity DataEC50:  1.40E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601803(CHEMBL5200409)
Affinity DataEC50:  1.30E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601810(CHEMBL5202293)
Affinity DataEC50:  2.20E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601812(CHEMBL5175986)
Affinity DataEC50:  3.50E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601804(CHEMBL5176162)
Affinity DataEC50:  2.30E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601813(CHEMBL5177628)
Affinity DataEC50:  3.50E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601805(CHEMBL5208399)
Affinity DataEC50:  3.50E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601814(CHEMBL5191014)
Affinity DataEC50:  2.50E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601815(CHEMBL5204049)
Affinity DataEC50:  3.70E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601806(CHEMBL5204388)
Affinity DataEC50:  1.70E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601807(CHEMBL5206413)
Affinity DataEC50:  2.70E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601808(CHEMBL5207900)
Affinity DataEC50:  4.10E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601816(CHEMBL5207841)
Affinity DataEC50:  4.40E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601817(CHEMBL5199314)
Affinity DataEC50:  4.30E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601809(CHEMBL5175068)
Affinity DataEC50:  3.20E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601811(CHEMBL5189627)
Affinity DataEC50:  3.80E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601818(CHEMBL5191357)
Affinity DataEC50:  2.80E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601819(CHEMBL5208555)
Affinity DataEC50:  120nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601820(CHEMBL5194960)
Affinity DataEC50: >5.00E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601821(CHEMBL5206387)
Affinity DataEC50:  43nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50009123(5-methyl-1H-indole-2-carboxylic acid | CHEMBL23328...)
Affinity DataKd:  2.00E+5nMAssay Description:Binding affinity to 8His-tagged Pin1 (45-163) PPIase domain by surface plasmon resonance spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
LigandPNGBDBM50305673(3-(1H-benzimidazol-2-yl)-N-(1-benzothiophen-2-ylca...)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to 8His-tagged Pin1 (45-163) PPIase domain by surface plasmon resonance spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
LigandPNGBDBM50305679((R)-methyl 2-(5-(4-(aminomethyl)phenyl)-2-methylfu...)
Affinity DataKd:  530nMAssay Description:Binding affinity to 8His-tagged Pin1 (45-163) PPIase domain by surface plasmon resonance spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
LigandPNGBDBM50329852(2-phenyl-1H-imidazole-4,5-dicarboxylic acid | CHEM...)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to Pin1 by isothermal calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandPNGBDBM50329853(2-(3-fluorophenyl)-1H-imidazole-4,5-dicarboxylic a...)
Affinity DataKd:  520nMAssay Description:Binding affinity to Pin1 by isothermal calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandPNGBDBM50329854(4-(benzyl(phenethyl)carbamoyl)-2-phenyl-1H-imidazo...)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of Pin1-mediated cyclin D1 expression in serum starved human PC3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandPNGBDBM50329854(4-(benzyl(phenethyl)carbamoyl)-2-phenyl-1H-imidazo...)
Affinity DataEC50:  3.00E+4nMAssay Description:Inhibition of Pin1 in serum starved human PC3 cells assessed as reduction in insulin-induced p7)S6 kinase phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandPNGBDBM50329855(2-(3-chlorophenyl)-4-(dibenzylcarbamoyl)-1H-imidaz...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to Pin1 by isothermal calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439947(CHEMBL2420310)
Affinity DataEC50:  109nMAssay Description:Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439946(CHEMBL2420287)
Affinity DataEC50:  166nMAssay Description:Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50319926(2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo...)
Affinity DataEC50:  136nMAssay Description:Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439948(CHEMBL2420425)
Affinity DataEC50:  426nMAssay Description:Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50156495(NU-7441 | NU-7432 | 8-Dibenzothiophen-4-yl-2-morph...)
Affinity DataEC50:  212nMAssay Description:Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50180850(CHEMBL3819587)
Affinity DataEC50:  27nMAssay Description:Inhibition of KEAP1/NRF2 interaction in human bronchial epithelial cells from COPD patient assessed as induction of TXNRD1 mRNA expression incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
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