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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM50577482(CHEMBL4848550)
Affinity DataEC50:  4.40E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM50577483(CHEMBL4869437)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM50577484(CHEMBL4863873)
Affinity DataEC50:  780nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataEC50:  290nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataEC50:  7.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349513(US10207991, Ex. Cpd. No. 28 | US10611728, Example ...)
Affinity DataEC50:  9.60E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataEC50:  2.60E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349518(US10207991, Ex. Cpd. No. 34 | US10611728, Example ...)
Affinity DataIC50: 15nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349520(US10207991, Ex. Cpd. No. 36 | US10611728, Example ...)
Affinity DataIC50: 19nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349528(US10207991, Ex. Cpd. No. 44 | US10611728, Example ...)
Affinity DataIC50: 99nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349519(US10207991, Ex. Cpd. No. 35 | US10611728, Example ...)
Affinity DataIC50: 130nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349531(US10207991, Ex. Cpd. No. 47 | US10611728, Example ...)
Affinity DataIC50: 130nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349529(US10207991, Ex. Cpd. No. 45 | US10611728, Example ...)
Affinity DataIC50: 220nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM435750(US10611728, Example Compound 13)
Affinity DataIC50: 250nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataIC50: 290nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349507(US10207991, Ex. Cpd. No. 22 | US10611728, Example ...)
Affinity DataIC50: 350nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349524(US10207991, Ex. Cpd. No. 40 | US10611728, Example ...)
Affinity DataIC50: 350nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349508(US10207991, Ex. Cpd. No. 23 | US10611728, Example ...)
Affinity DataIC50: 370nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349250(US10207991, Ex. Cpd. No. 1 | US10611728, Example C...)
Affinity DataIC50: 430nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349521(US10207991, Ex. Cpd. No. 37 | US10611728, Example ...)
Affinity DataIC50: 480nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349514(US10207991, Ex. Cpd. No. 29 | US10611728, Example ...)
Affinity DataIC50: 540nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataIC50: 570nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349505(US10207991, Ex. Cpd. No. 20 | US10611728, Example ...)
Affinity DataIC50: 660nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349527(US10207991, Ex. Cpd. No. 43 | US10611728, Example ...)
Affinity DataIC50: 670nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM435738(US10611728, Example Compound 2)
Affinity DataIC50: 710nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349556(US10207991, Ex. Cpd. No. 73 | US10611728, Example ...)
Affinity DataIC50: 770nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349546(US10207991, Ex. Cpd. No. 61 | US10611728, Example ...)
Affinity DataIC50: 790nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349526(US10207991, Ex. Cpd. No. 42 | US10611728, Example ...)
Affinity DataIC50: 800nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349509(US10207991, Ex. Cpd. No. 24 | US10611728, Example ...)
Affinity DataIC50: 860nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349517(US10207991, Ex. Cpd. No. 33 | US10611728, Example ...)
Affinity DataIC50: 910nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM435742(US10611728, Example Compound 6)
Affinity DataIC50: 980nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349535(US10207991, Ex. Cpd. No. 51 | US10611728, Example ...)
Affinity DataIC50: 1.20E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349530(US10207991, Ex. Cpd. No. 46 | US10611728, Example ...)
Affinity DataIC50: 1.60E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349532(US10207991, Ex. Cpd. No. 48 | US10611728, Example ...)
Affinity DataIC50: 1.70E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetAmyloid-beta precursor protein(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50089193(4-Fluoro-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-y...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of A-beta-42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349516(US10207991, Ex. Cpd. No. 31 | US10611728, Example ...)
Affinity DataIC50: 1.90E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349522(US10207991, Ex. Cpd. No. 38 | US10611728, Example ...)
Affinity DataIC50: 2.10E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM435751(US10611728, Example Compound 14)
Affinity DataIC50: 2.40E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349538(US10207991, Ex. Cpd. No. 54 | US10611728, Example ...)
Affinity DataIC50: 2.50E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetAmyloid-beta precursor protein(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50089190(Thiophene-2-sulfonic acid (1,3,3-trimethyl-bicyclo...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of A-beta-42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349525(US10207991, Ex. Cpd. No. 41 | US10611728, Example ...)
Affinity DataIC50: 2.80E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349537(US10207991, Ex. Cpd. No. 53 | US10611728, Example ...)
Affinity DataIC50: 2.80E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349570(US10207991, Ex. Cpd. No. 88 | US10611728, Example ...)
Affinity DataIC50: 2.80E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349555(US10207991, Ex. Cpd. No. 70 | US10611728, Example ...)
Affinity DataIC50: 3.10E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349510(US10207991, Ex. Cpd. No. 25 | US10611728, Example ...)
Affinity DataIC50: 3.20E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349512(US10207991, Ex. Cpd. No. 27 | US10611728, Example ...)
Affinity DataIC50: 3.20E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349523(US10207991, Ex. Cpd. No. 39 | US10611728, Example ...)
Affinity DataIC50: 3.20E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349536(US10207991, Ex. Cpd. No. 52 | US10611728, Example ...)
Affinity DataIC50: 3.20E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349511(US10207991, Ex. Cpd. No. 26 | US10611728, Example ...)
Affinity DataIC50: 3.70E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

Curated by ChEMBL
LigandPNGBDBM349534(US10207991, Ex. Cpd. No. 50 | US10611728, Example ...)
Affinity DataIC50: 4.40E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

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