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TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062357(CHEMBL3397300 | AP26113)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185287(CHEMBL3823268)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185237(CHEMBL3824308)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human LYN using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185275(CHEMBL3823235)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185280(CHEMBL3822611)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of wild type human ABL using [EAIYAAPFAKKK] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human RET using KKKSPGEYVNIEFG by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of wild type human ABL using [EAIYAAPFAKKK] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185284(CHEMBL3823549)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185281(CHEMBL3823416)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185268(CHEMBL3824327)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185290(CHEMBL3824304)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185272(CHEMBL3823107)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185283(CHEMBL3823603)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185286(CHEMBL3823256)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185278(CHEMBL3823017)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of ABL autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185245(CHEMBL3823190)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185239(CHEMBL3823296)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185286(CHEMBL3823256)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185238(CHEMBL3823577)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50314074(2,6,9-Trisubstitute purine, 6 (AP23464) | CHEMBL10...)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of 6x-His-tagged human Src kinase domain (T250 to L536 residues) expressed in Sf9 cells incubated for 2 hrs in presence of biotinylated cd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185288(CHEMBL3824326)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185265(CHEMBL3824290)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185267(CHEMBL3822557)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185270(CHEMBL3823031)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185282(CHEMBL3823916)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185152(CHEMBL3822475)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185279(CHEMBL3824007)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human EPHA2 using poly[Glu:Tyr] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185233(CHEMBL3823224)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185287(CHEMBL3823268)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185274(CHEMBL3824130)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185161(CHEMBL3822672)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185234(CHEMBL3824318)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185152(CHEMBL3822475)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185246(CHEMBL3822645)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185288(CHEMBL3824326)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185163(CHEMBL3824246)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185235(CHEMBL3823836 | US20230322822, Control compound 2)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185288(CHEMBL3824326)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of human InsR using myelin basic protein as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185247(CHEMBL3823243)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185271(CHEMBL3823218)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185289(CHEMBL3822982)
Affinity DataIC50: 0.960nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185153(CHEMBL3822499)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
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