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TargetGlucagon-like peptide 1 receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301949(CHEMBL583264)
Affinity DataEC50:  0.0340nMAssay Description:Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation after 30 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetMotilin receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50143028(8'N-[1-[1-carbamoyl-3-phenyl-(1S)-propylcarbamoyl]...)
Affinity DataEC50:  0.0470nMAssay Description:In vitro effective concentration towards human motilin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301952((3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-im...)
Affinity DataEC50:  0.0870nMAssay Description:Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation after 30 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301953((3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-im...)
Affinity DataEC50:  0.0930nMAssay Description:Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation after 30 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
LigandPNGBDBM32522(pyridine amide, 30)
Affinity DataIC50: 0.100nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2009
Entry Details Article
PubMed
TargetMotilin receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50143037(CHEMBL411576 | MOTILIN)
Affinity DataEC50:  0.150nMAssay Description:In vitro effective concentration towards human motilin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50376781(CHEMBL410085)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50376783(CHEMBL259166)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

LigandPNGBDBM29320(BMS-665139 | oxazolidin-2-imine, 6c)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/mole EC50:  0.200nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

LigandPNGBDBM29321(oxazolidin-2-imine, 6d)
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/mole EC50:  19nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50376760(CHEMBL410074)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMotilin receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50143038(8'N-[1-[1-carbamoyl-3-phenyl-(1S)-propylcarbamoyl]...)
Affinity DataEC50:  0.220nMAssay Description:In vitro effective concentration towards human motilin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

LigandPNGBDBM50215709(CHEMBL1170 | Propionic acid 10,13-dimethyl-3-oxo-2...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]DHT from human androgen receptor in MDA453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50243597((R)-2-(5-(1-(2-amino-2-methylpropanamido)-4,4-difl...)
Affinity DataEC50:  0.270nMAssay Description:Agonist activity at GHS receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301951((3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-im...)
Affinity DataEC50:  0.280nMAssay Description:Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation after 30 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239610(CHEMBL4073961)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes using [3H]cortisone as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/mole EC50:  2.80nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

LigandPNGBDBM29319(oxazolidin-2-imine, 6b)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/mole EC50:  14nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

LigandPNGBDBM29323(oxazolidin-2-imine, 6f)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/mole EC50:  1.40nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50371684(CHEMBL270666)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50235838((4-hydroxy-butyl)-carbamic acid 2-{5-[(S)-1-(2-ami...)
Affinity DataEC50:  0.340nMAssay Description:Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMotilin receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50143032(8'N-[1-(1-carbamoyl-3-phenylpropylcarbamoyl)-3-phe...)
Affinity DataEC50:  0.350nMAssay Description:In vitro effective concentration towards human motilin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50371688(CHEMBL404545)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50371686(CHEMBL271876)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50235845((S)-2-(5-(2-(2,4-difluorobenzyloxy)-1-(2-amino-2-m...)
Affinity DataEC50:  0.420nMAssay Description:Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Mouse)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM18173(4-[(7R,7aS)-7-hydroxy-1,3-dioxo-hexahydro-1H-pyrro...)
Affinity DataEC50:  0.440nMAssay Description:Agonist activity at androgen receptor in mouse C2C12 cells by receptor transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50235842((S)-2-(5-(2-(2-chlorobenzyloxy)-1-(2-amino-2-methy...)
Affinity DataEC50:  0.450nMAssay Description:Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

LigandPNGBDBM50215713(2-chloro-4-((3aS,4R)-4-hydroxy-1,1,3-trioxo-tetrah...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]DHT from human androgen receptor in MDA453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50410108(CHEMBL179823)
Affinity DataEC50:  0.460nMAssay Description:In vitro effective concentration against human growth hormone secretagoguesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50410123(CHEMBL180094)
Affinity DataEC50:  0.460nMAssay Description:In vivo effective concentration against human growth hormone secretagoguesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50410123(CHEMBL180094)
Affinity DataEC50:  0.460nMAssay Description:In vitro effective concentration against human growth hormone secretagoguesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.480nMAssay Description:Ability to activate estrogen receptor 1-mediated transcription.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50410114(CHEMBL360547)
Affinity DataEC50:  0.490nMAssay Description:In vitro effective concentration against human growth hormone secretagoguesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50410123(CHEMBL180094)
Affinity DataEC50:  0.490nMAssay Description:In vitro effective concentration against human growth hormone secretagoguesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50410114(CHEMBL360547)
Affinity DataEC50:  0.490nMAssay Description:In vivo effective concentration against human growth hormone secretagoguesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50410123(CHEMBL180094)
Affinity DataEC50:  0.490nMAssay Description:In vitro effective concentration against human growth hormone secretagoguesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50054701(CHEMBL3318967)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant 11beta-HSD-1 expressed in HEK293 EBNA cells using [3H]-cortisone and NADPH by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

LigandPNGBDBM18188(4-[(1S,7aR)-1-hydroxy-7-methyl-5-oxo-2,3,5,7a-tetr...)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/mole EC50:  2nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50507376(CHEMBL4453347)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant human 11beta-HSD1 expressed in HEK293 cell microsomes using [3H]cortisone as substrate after 4 hrs by homogeneous immuno-ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50235849((4-hydroxy-butyl)-carbamic acid 2-{5-[(S)-1-(2-ami...)
Affinity DataEC50:  0.510nMAssay Description:Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataIC50: 10nM EC50:  0.590nMAssay Description:Ligand binding was determined using a scintillation proximity assay with streptavidin-coated SPA beads (Amersham) and biotinylated receptor. Receptor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239632(CHEMBL4071232)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes using [3H]cortisone as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 2(Human)
Bristol-Myers Squibb

Curated by PDSP Ki Database
LigandPNGBDBM82279(CAS_118997-30-1 | PYY, human)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2011
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

LigandPNGBDBM50205116(2-bromo-4-((7R,7aS)-7-hydroxy-1,3-dioxo-tetrahydro...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human ARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50376761(CHEMBL411259)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085044(2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-phen...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50235854((S)-2-(5-(2-(2,3-dichlorobenzyloxy)-1-(2-amino-2-m...)
Affinity DataEC50:  0.610nMAssay Description:Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50054690(CHEMBL3318979)
Affinity DataIC50: 0.610nMAssay Description:Inhibition of human recombinant 11beta-HSD-1 expressed in HEK293 EBNA cells using [3H]-cortisone and NADPH by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50376777(CHEMBL410135)
Affinity DataEC50:  0.640nMAssay Description:Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50410135(CHEMBL369329)
Affinity DataEC50:  0.660nMAssay Description:In vitro effective concentration against human growth hormone secretagoguesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
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