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TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111911(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  3.70E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111925(4-{2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111924(5-Methyl-isoxazole-3-carboxylic acid 3-(9-chloro-3...)
Affinity DataEC50:  7.90E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111923(9-Chloro-3-methyl-5-{3-[(3,4,5-trimethoxy-benzylam...)
Affinity DataEC50:  1.77E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111922(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  3.20E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111914(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  1.30E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111915(LY-402913 | 2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxa...)
Affinity DataEC50:  900nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111921(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  4.10E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111920(N-Benzo[1,3]dioxol-5-yl-2-[3-(9-chloro-3-methyl-4-...)
Affinity DataEC50:  4.00E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111919(N-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  1.13E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111918(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  2.30E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111916(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  4.90E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111917(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111913(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  1.80E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111912(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  2.10E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111910(9-Chloro-3-methyl-5-{3-[2-(3,4,5-trimethoxy-phenox...)
Affinity DataEC50:  1.47E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111909(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111907(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111926(5-Methyl-isoxazole-3-carboxylic acid [(1R,2R)-6-(9...)
Affinity DataEC50:  1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111927(N-(4-tert-Butyl-phenyl)-2-[3-(9-chloro-3-methyl-4-...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111908(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  640nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50174854(N-(((1R,3S)-3-(9-chloro-3-methyl-4-oxoisoxazolo[4,...)
Affinity DataEC50:  180nMAssay Description:Inhibitory activity against MRP1 in HeLa-T5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50174852(rac-N-((3-(9-chloro-3-methyl-4-oxoisoxazolo[4,3-c]...)
Affinity DataEC50:  250nMAssay Description:Inhibitory activity against MRP1 in HeLa-T5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50174855(rac-N-((3-(9-chloro-3-methyl-4-oxoisoxazolo[4,3-c]...)
Affinity DataEC50:  420nMAssay Description:Inhibitory activity against MRP1 in HeLa-T5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50174853(rac-N-((3-(9-chloro-3-methyl-4-oxoisoxazolo[4,3-c]...)
Affinity DataEC50:  640nMAssay Description:Inhibitory activity against MRP1 in HeLa-T5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50174854(N-(((1R,3S)-3-(9-chloro-3-methyl-4-oxoisoxazolo[4,...)
Affinity DataIC50: 38nMAssay Description:Inhibitory activity against MRP1-mediated LTC4 uptake into membrane vesicles from HeLa-T5 cells expressing MRP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50174852(rac-N-((3-(9-chloro-3-methyl-4-oxoisoxazolo[4,3-c]...)
Affinity DataIC50: 270nMAssay Description:Inhibitory activity against MRP1-mediated LTC4 uptake into membrane vesicles from HeLa-T5 cells expressing MRP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50174853(rac-N-((3-(9-chloro-3-methyl-4-oxoisoxazolo[4,3-c]...)
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibitory activity against MRP1-mediated LTC4 uptake into membrane vesicles from HeLa-T5 cells expressing MRP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073754((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...)
Affinity DataKi:  0.290nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073752(LY-335580 | (R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetr...)
Affinity DataKi:  0.690nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073753((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)
Affinity DataKi:  9.90nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50073753((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)
Affinity DataKi:  710nMAssay Description:Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073754((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory activity against recombinant human Thymidylate synthase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073753((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory activity against recombinant human Thymidylate synthase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073752(LY-335580 | (R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetr...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory activity against recombinant human Thymidylate synthase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50073752(LY-335580 | (R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetr...)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50073754((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...)
Affinity DataKi:  5.60E+4nMAssay Description:Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed