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TargetAtypical chemokine receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250377(CHEMBL4070758)
Affinity DataEC50:  46nMAssay Description:Modulation of ProLink-fused human CXCR7 expressed in CHOK1 cell membranes assessed as induction of EA-tagged beta-arrestin recruitment after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250375(CHEMBL4077017)
Affinity DataEC50:  15nMAssay Description:Modulation of ProLink-fused human CXCR7 expressed in CHOK1 cell membranes assessed as induction of EA-tagged beta-arrestin recruitment after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342538(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azep...)
Affinity DataEC50:  190nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019660(CHEMBL3286558)
Affinity DataEC50:  1.46E+3nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019661(CHEMBL3286559)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019662(CHEMBL3286560)
Affinity DataEC50:  51nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019663(CHEMBL3286561)
Affinity DataEC50:  39nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019664(CHEMBL3286562)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019674(CHEMBL3286563)
Affinity DataEC50:  154nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019682(CHEMBL3286564)
Affinity DataEC50:  33nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Dog)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342538(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azep...)
Affinity DataEC50:  3.40E+3nMAssay Description:Agonist activity at 5-HT2A receptor in beagle dog femoral arteries tissue after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Dog)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019662(CHEMBL3286560)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at 5-HT2A receptor in beagle dog femoral arteries tissue after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019691(CHEMBL3286565)
Affinity DataEC50:  112nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019691(CHEMBL3286565)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019692(CHEMBL3286566)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019694(CHEMBL3286554)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019695(CHEMBL3286555)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019685(CHEMBL3286556)
Affinity DataEC50:  10nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019696(CHEMBL3286557)
Affinity DataEC50:  16nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342538(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azep...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019662(CHEMBL3286560)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019663(CHEMBL3286561)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019674(CHEMBL3286563)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019682(CHEMBL3286564)
Affinity DataEC50:  247nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019691(CHEMBL3286565)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019691(CHEMBL3286565)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019692(CHEMBL3286566)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019694(CHEMBL3286554)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019685(CHEMBL3286556)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019696(CHEMBL3286557)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019685(CHEMBL3286556)
Affinity DataIC50: 67nMAssay Description:Binding affinity to 5HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50285934(1-[2-((S)-3-Benzoylamino-2-oxo-4-phenyl-butylamino...)
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against angiotensin converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019696(CHEMBL3286557)
Affinity DataIC50: 110nMAssay Description:Binding affinity to 5HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019696(CHEMBL3286557)
Affinity DataIC50: 119nMAssay Description:Binding affinity to 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019685(CHEMBL3286556)
Affinity DataIC50: 280nMAssay Description:Binding affinity to 5HT6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019685(CHEMBL3286556)
Affinity DataIC50: 360nMAssay Description:Binding affinity to 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019685(CHEMBL3286556)
Affinity DataIC50: 500nMAssay Description:Binding affinity to 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019696(CHEMBL3286557)
Affinity DataIC50: 610nMAssay Description:Binding affinity to 5HT1B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019696(CHEMBL3286557)
Affinity DataIC50: 1.40E+3nMAssay Description:Binding affinity to adrenergic beta-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50285932(1-[2-(2-Benzoylamino-3-phenyl-propionylamino)-acet...)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibitory activity against angiotensin converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetAtypical chemokine receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250387(CHEMBL4102791)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250387(CHEMBL4102791)
Affinity DataKi:  5.01nMAssay Description:Modulation of ProLink-fused human CXCR7 expressed in CHOK1 cell membranes assessed as induction of EA-tagged beta-arrestin recruitment after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250402(CHEMBL4084835)
Affinity DataKi:  7.90nMAssay Description:Modulation of ProLink-fused human CXCR7 expressed in CHOK1 cell membranes assessed as induction of EA-tagged beta-arrestin recruitment after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250402(CHEMBL4084835)
Affinity DataKi:  8nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019696(CHEMBL3286557)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]-mesulergine from human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250375(CHEMBL4077017)
Affinity DataKi:  9nMAssay Description:Modulation of ProLink-fused human CXCR7 expressed in CHOK1 cell membranes assessed as induction of EA-tagged beta-arrestin recruitment after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250395(CHEMBL4103373)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250395(CHEMBL4103373)
Affinity DataKi:  9nMAssay Description:Modulation of ProLink-fused human CXCR7 expressed in CHOK1 cell membranes assessed as induction of EA-tagged beta-arrestin recruitment after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250375(CHEMBL4077017)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50019685(CHEMBL3286556)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-mesulergine from human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
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