Compile Data Set for Download or QSAR
Report error Found 2356 with Last Name = 'showalter' and Initial = 'hd'
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3084(6-(2,6-dichlorophenyl)-2-[(4-hydroxyphenyl)amino]-...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3088(ethyl 3-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
LigandPNGBDBM3444(6-(2,6-dichlorophenyl)-2-N-[2-(diethylamino)ethyl]...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3444(6-(2,6-dichlorophenyl)-2-N-[2-(diethylamino)ethyl]...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3444(6-(2,6-dichlorophenyl)-2-N-[2-(diethylamino)ethyl]...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3449(6-(2,6-dichlorophenyl)-2-N-[4-(diethylamino)butyl]...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3454(6-(2,6-dichlorophenyl)-2-N-[3-(dimethylamino)propy...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3449(6-(2,6-dichlorophenyl)-2-N-[4-(diethylamino)butyl]...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3454(6-(2,6-dichlorophenyl)-2-N-[3-(dimethylamino)propy...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3449(6-(2,6-dichlorophenyl)-2-N-[4-(diethylamino)butyl]...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3454(6-(2,6-dichlorophenyl)-2-N-[3-(dimethylamino)propy...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3456(6-(2,6-dichlorophenyl)-2-N-[3-(dimethylamino)propy...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3458(6-(2,6-dichlorophenyl)-2-N-{2-[(dimethylamino)meth...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3460(6-(2,6-dichlorophenyl)-2-N-[3-(morpholin-4-yl)prop...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3462(6-(2,6-dichlorophenyl)-2-N-[3-(2-methylpiperidin-1...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3456(6-(2,6-dichlorophenyl)-2-N-[3-(dimethylamino)propy...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3458(6-(2,6-dichlorophenyl)-2-N-{2-[(dimethylamino)meth...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3460(6-(2,6-dichlorophenyl)-2-N-[3-(morpholin-4-yl)prop...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3462(6-(2,6-dichlorophenyl)-2-N-[3-(2-methylpiperidin-1...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3456(6-(2,6-dichlorophenyl)-2-N-[3-(dimethylamino)propy...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3458(6-(2,6-dichlorophenyl)-2-N-{2-[(dimethylamino)meth...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3460(6-(2,6-dichlorophenyl)-2-N-[3-(morpholin-4-yl)prop...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3462(6-(2,6-dichlorophenyl)-2-N-[3-(2-methylpiperidin-1...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3466(6-(2,6-dichlorophenyl)-2-N-[4-(4-methylpiperazin-1...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3466(6-(2,6-dichlorophenyl)-2-N-[4-(4-methylpiperazin-1...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3466(6-(2,6-dichlorophenyl)-2-N-[4-(4-methylpiperazin-1...)
Affinity DataAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Penn State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataEC50:  3nMAssay Description:Inhibition of atypical PKCzeta in HEK293 cells assessed as TNF-induced NFkappaB activation incubated for 3 hrs prior to TNF induction measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Penn State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM139468(US8889672, 317-054-001)
Affinity DataEC50:  10nMAssay Description:Inhibition of atypical PKCzeta in HEK293 cells assessed as TNF-induced NFkappaB activation incubated for 3 hrs prior to TNF induction measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Penn State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM139466(US8889672, 317-094-001)
Affinity DataEC50:  1nMAssay Description:Inhibition of atypical PKCzeta in HEK293 cells assessed as TNF-induced NFkappaB activation incubated for 3 hrs prior to TNF induction measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Penn State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM139469(US8889672, 317-052-004)
Affinity DataEC50:  1nMAssay Description:Inhibition of atypical PKCzeta in HEK293 cells assessed as TNF-induced NFkappaB activation incubated for 3 hrs prior to TNF induction measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Penn State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM139465(US8889672, 317-080-001)
Affinity DataEC50:  1nMAssay Description:Inhibition of atypical PKCzeta in HEK293 cells assessed as TNF-induced NFkappaB activation incubated for 3 hrs prior to TNF induction measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Penn State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM139472(US8889672, 252-036-001)
Affinity DataEC50:  2nMAssay Description:Inhibition of atypical PKCzeta in HEK293 cells assessed as TNF-induced NFkappaB activation incubated for 3 hrs prior to TNF induction measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Penn State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM139464(US8889672, 194-074-007 | US8889672, PKCzI-diMeO)
Affinity DataEC50:  3nMAssay Description:Inhibition of atypical PKCzeta in HEK293 cells assessed as TNF-induced NFkappaB activation incubated for 3 hrs prior to TNF induction measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Penn State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM139467(US8889672, 268-020-002)
Affinity DataEC50:  2nMAssay Description:Inhibition of atypical PKCzeta in HEK293 cells assessed as TNF-induced NFkappaB activation incubated for 3 hrs prior to TNF induction measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50355759(CHEMBL1911299)
Affinity DataEC50:  2.10E+3nMAssay Description:Activation of human PXR in DPX2 cells after 24 hrs by microplate reader relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50355760(CHEMBL1911307)
Affinity DataEC50:  4.10E+3nMAssay Description:Activation of human PXR in DPX2 cells after 24 hrs by microplate reader relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50370232(BA-41166E | L-5103 | Rifadin | Rifampicin | RIFAMP...)
Affinity DataEC50:  5.60E+3nMAssay Description:Activation of human PXR in DPX2 cells after 24 hrs by microplate reader relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50386752(CHEMBL2046887)
Affinity DataEC50:  5.50E+3nMAssay Description:Activation of PXR in human DPX2 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50370232(BA-41166E | L-5103 | Rifadin | Rifampicin | RIFAMP...)
Affinity DataEC50:  2.30E+3nMAssay Description:Activation of PXR in human DPX2 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3585(4-[(3-Bromophenyl)amino]benzo[g]quinazoline | N-(3...)
Affinity DataIC50: 0.00300nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3604(CHEMBL53711 | 4-[(3-bromophenyl)-amino]-6-(dimethy...)
Affinity DataIC50: 0.00600nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3570(N-(3-bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-am...)
Affinity DataIC50: 0.00800nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3603(4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimid...)
Affinity DataIC50: 0.00800nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3603(4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimid...)
Affinity DataIC50: 0.00800nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3570(N-(3-bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-am...)
Affinity DataIC50: 0.00800nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3572(N-(3-bromophenyl)-1-methyl-1H-imidazo[4,5-g]quinaz...)
Affinity DataIC50: 0.0100nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3574(8-[(3-Bromophenyl)amino]-3-methyl-3H-imidazo[4,5-g...)
Affinity DataIC50: 0.0250nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3595(4-N-(3-bromophenyl)-7-N,7-N-dimethylpyrido[4,3-d]p...)
Affinity DataIC50: 0.0900nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3594(4-N-(3-bromophenyl)-7-N-methylpyrido[4,3-d]pyrimid...)
Affinity DataIC50: 0.130nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3600(4-N-(3-bromophenyl)pyrido[3,4-d]pyrimidine-4,6-dia...)
Affinity DataIC50: 0.130nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2005
Entry Details Article
PubMed
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