Report error Found 540 with Last Name = 'silva' and Initial = 'r'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Inhibition of human recombinant PDE4D using [3H]cAMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Human)
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC1 receptor expressed in human HCT116 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human recombinant PDE4A using [3H]cAMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Human)
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 0.240nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC1 receptor expressed in human HCT116 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina
Curated by ChEMBL
Universidade Federal De Santa Catarina
Curated by ChEMBL
Affinity DataKd: 0.380nMAssay Description:Binding affinity to SUR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.389nMAssay Description:Displacement of [3H]prazosin from human alpha1A-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Pontifical Catholic University of Rio Grande Do Sul
Curated by ChEMBL
Pontifical Catholic University of Rio Grande Do Sul
Curated by ChEMBL
Affinity DataKd: <0.400nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv InhA assessed as dissociation constant in presence of NADH, octenoyl-CoA and KatGMore data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas
Curated by ChEMBL
Federal University of Alagoas
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Binding affinity to Trypanosoma brucei rhodesainMore data for this Ligand-Target Pair
Affinity DataIC50: 0.550nMAssay Description:Inhibition of human guanine-N7 methyltransferase expressed in Saccharomyces cerevisiae YBS40 (MATa leu2 ade2 trp1 his3 ura3 can1 abd1::hisGp360-ABD1)More data for this Ligand-Target Pair
Affinity DataKi: 0.603nMAssay Description:Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
TargetMelanocortin receptor 5(Human)
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 0.710nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Pontifical Catholic University of Rio Grande Do Sul
Curated by ChEMBL
Pontifical Catholic University of Rio Grande Do Sul
Curated by ChEMBL
Affinity DataKi: 0.75nMAssay Description:Binding affinity to wild type Mycobacterium tuberculosis InhA assessed as inhibition constant in presence of NADH, DD-CoA by spectrophotometry based ...More data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Human)
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 0.75nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC4 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
TargetMelanocortin receptor 5(Human)
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 0.760nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Human)
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 0.770nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC4 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]prazosin from human alpha1A-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]prazosin from human alpha1A-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
TargetMelanocortin receptor 5(Human)
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Human)
Magna Graecia University of Catanzaro
Curated by ChEMBL
Magna Graecia University of Catanzaro
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI-TN- 5B1-4 insect cells using kynuramine as substrate preincubated for 10 ...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant PDE4C using [3H]cAMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Human)
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC4 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Human)
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 1.80nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC1 receptor expressed in human HCT116 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Human)
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 1.80nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC1 receptor expressed in human HCT116 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Human)
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC1 receptor expressed in human HCT116 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [3H]prazosin from human alpha1A-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina
Curated by ChEMBL
Universidade Federal De Santa Catarina
Curated by ChEMBL
Affinity DataKd: 2.10nMAssay Description:Binding affinity to SUR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H]prazosin from human alpha1A-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H]prazosin from human alpha1A-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Human)
Magna Graecia University of Catanzaro
Curated by ChEMBL
Magna Graecia University of Catanzaro
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI-TN- 5B1-4 insect cells using kynuramine as substrate preincubated for 10 ...More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Human)
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC1 receptor expressed in human HCT116 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.60nMAssay Description:Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human microsomal MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as reduction in 4-hydroxyquinoline formation using...More data for this Ligand-Target Pair
Affinity DataKi: 2.80nMAssay Description:Displacement of [3H]prazosin from human alpha1A-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Human)
Magna Graecia University of Catanzaro
Curated by ChEMBL
Magna Graecia University of Catanzaro
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI-TN- 5B1-4 insect cells using kynuramine as substrate preincubated for 10 ...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [3H]prazosin from human alpha1A-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas
Curated by ChEMBL
Federal University of Alagoas
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Human)
Magna Graecia University of Catanzaro
Curated by ChEMBL
Magna Graecia University of Catanzaro
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI-TN- 5B1-4 insect cells using kynuramine as substrate preincubated for 10 ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI-TN- 5B1-4 insect cells using kynuramine as substrate preincubated for 10 ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Human)
Magna Graecia University of Catanzaro
Curated by ChEMBL
Magna Graecia University of Catanzaro
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI-TN- 5B1-4 insect cells using kynuramine as substrate preincubated for 10 ...More data for this Ligand-Target Pair

3D Structure (crystal)





























