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TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91698(Oxazolamine derivative, 5a)
Affinity DataEC50:  3.50E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91699(Oxazolamine derivative, 5b)
Affinity DataEC50:  9.00E+3nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91700(Oxazolamine derivative, 5c)
Affinity DataEC50:  2.00E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91701(Oxazolamine derivative, 5d)
Affinity DataEC50:  5.00E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91702(Oxazolamine derivative, 5e)
Affinity DataEC50: >2.00E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91703(Oxazolamine derivative, 5f)
Affinity DataEC50:  1.20E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50176808(6-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-be...)
Affinity DataEC50:  7.00E+3nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50253810(R115866 | CHEMBL459505 | N-(4-(2-ethyl-1-(1H-1,2,4...)
Affinity DataEC50:  5nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91704(1H-1,2,4-triazole, 11)
Affinity DataEC50:  1.80E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91705(1H-1,2,4-triazole, 12)
Affinity DataEC50: >2.00E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91706(1H-tetrazole, 13)
Affinity DataEC50: >2.00E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50539776(CHEMBL4639677)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50539777(CHEMBL4632445)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592781(CHEMBL5203413)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM10007(4-[6-Methoxybenzofuran-2-yl)-1H-1,2,4-triazol-1-yl...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM10004(1-[(4-fluorophenyl)(6-methoxy-1-benzofuran-2-yl)me...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50353578(CHEMBL1831092)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of CYP26 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50353578(CHEMBL1831092)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human CYP26A1 assessed using [11,12-3H]ATRA as substrate by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50353582(CHEMBL1831083)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human CYP26A1 assessed using [11,12-3H]ATRA as substrate by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592778(CHEMBL5175340)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50608157(CHEMBL5271052)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione [1beta-3H] as substrate incubated for 1 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592775(CHEMBL5184004)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM10001((4-chlorophenyl)(6-methoxy-1-benzofuran-2-yl)pyrid...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione [1beta-3H] as substrate incubated for 1 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM10005(1-[(4-chlorophenyl)(6-methoxy-1-benzofuran-2-yl)me...)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592780(CHEMBL5177269)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592777(CHEMBL5174567)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM10013(4-[(6-hydroxy-1-benzofuran-2-yl)(1H-1,2,4-triazol-...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM13061(CHEMBL1444 | 4-[(4-cyanophenyl)(1H-1,2,4-triazol-1...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM13061(CHEMBL1444 | 4-[(4-cyanophenyl)(1H-1,2,4-triazol-1...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione [1beta-3H] as substrate incubated for 1 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592782(CHEMBL5179009)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM10000(6-Methoxybenzofuran-2-yl-(4-fluorophenyl)-3-pyridy...)
Affinity DataIC50: 0.740nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione [1beta-3H] as substrate incubated for 1 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50539775(CHEMBL4634777)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM10012(2-[(4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-...)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50608161(CHEMBL5283822)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione [1beta-3H] as substrate incubated for 1 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50608164(CHEMBL5280326)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione [1beta-3H] as substrate incubated for 1 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592776(CHEMBL5197552)
Affinity DataIC50: 1nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50608160(CHEMBL5272700)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione [1beta-3H] as substrate incubated for 1 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50608158(CHEMBL5278036)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione [1beta-3H] as substrate incubated for 1 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592770(CHEMBL5186519)
Affinity DataIC50: 2nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50176808(6-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-be...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human MBP-tagged CYP24A1 expressed in Escherichia coli using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reduc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592768(CHEMBL5205534)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342128(3-Imidazol-1-yl-2-methyl-3-[4-(naphthalen-2-ylamin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342130(3-[4-(6-Hydroxy-naphthalen-2-ylamino)-phenyl]-3-im...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342128(3-Imidazol-1-yl-2-methyl-3-[4-(naphthalen-2-ylamin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP26 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342128(3-Imidazol-1-yl-2-methyl-3-[4-(naphthalen-2-ylamin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CYP26A1 assessed using [11,12-3H]ATRA as substrate by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592779(CHEMBL5173597)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50608165(CHEMBL5277776)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione [1beta-3H] as substrate incubated for 1 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50377963(R-115866 | CHEMBL224305)
Affinity DataIC50: 5nMAssay Description:Inhibition of CYP26A1 in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592769(CHEMBL5178202)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50391726(CHEMBL2146987)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of CYP26A1-mediated retinoic acid metabolism in human MCF7 cell microsomes using [3H]ATRA as substrate after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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