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TargetG-protein coupled receptor 55(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50552131(CHEMBL3402654)
Affinity DataEC50:  2nMAssay Description:Activation of recombinant human GPR55 expressed in HEK293 cells assessed as increase in [35S]-GTPgammaS stimulation incubated for 60 min by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 55(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50552130(CHEMBL499876)
Affinity DataEC50:  2nMAssay Description:Activation of recombinant human GPR55 expressed in HEK293 cells assessed as increase in [35S]-GTPgammaS stimulation incubated for 60 min by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataKd:  4.80E+3nMAssay Description:Binding affinity to DNA-tagged Aurora B (unknown origin) expressed in mammalian system assessed as binding constant (Kd) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataKd:  67nMAssay Description:Binding affinity to DNA-tagged EGFR (unknown origin) expressed in bacterial system assessed as binding constant (Kd) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50318484(CHEMBL190461 | 2-((1R,6R)-6-Isopropenyl-3-methyl-c...)
Affinity DataEC50:  3.20E+4nMAssay Description:Displacement of [3H] ketanserin from rat 5-HT2aR expressed in mouse NIH/3T3 cells incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to DNA-tagged Aurora A (unknown origin) expressed in mammalian system assessed as binding constant (Kd) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50318484(CHEMBL190461 | 2-((1R,6R)-6-Isopropenyl-3-methyl-c...)
Affinity DataEC50:  8.00E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-HT1a receptor expressed in CHO cells incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetAlpha-amylase 1A(Human)
IK Gujral Punjab Technical University

Curated by ChEMBL
LigandPNGBDBM50643504(CHEMBL5563361)
Affinity DataIC50: 0.130nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of Aurora A (unknown origin) using kemptide as substrate incubated for 50 mins in the presence of ATP by ADP-Glo reagent based luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
New York University

Curated by ChEMBL
LigandPNGBDBM50036730(3-[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl...)
Affinity DataIC50: 0.5nMAssay Description:Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]haloperidol in the presence of 25 nM unlabeled spiperoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50587744(CHEMBL5177936)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of human BuchE preincubated for 6 mins followed by substrate addition and measured upto 3 mins using acetylthiocholine iodide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCholinesterase(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50587744(CHEMBL5177936)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of human BuchE preincubated for 6 mins followed by substrate addition and measured upto 3 mins using acetylthiocholine iodide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50250824(CHEMBL4101278)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM21190(CHEMBL113142 | 4-(2-{[5-amino-2-(furan-2-yl)-[1,2,...)
Affinity DataIC50: 1.5nMAssay Description:Inverse agonist activity at human A2A receptor assessed as inhibition of cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50067186(CHEMBL3401745)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PDE5A1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50067186(CHEMBL3401745)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human PDE5A1 expressed in baculovirus in sf9 cells by PDE Glo phosphodiesterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50067195(CHEMBL3401754)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human PDE5A1 expressed in baculovirus in sf9 cells by PDE Glo phosphodiesterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50594634(CHEMBL5182250)
Affinity DataIC50: 1.60nMAssay Description:Inverse agonist activity at human A2A receptor assessed as inhibition of basal cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50067187(CHEMBL3401746)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human PDE5A1 expressed in baculovirus in sf9 cells by PDE Glo phosphodiesterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50211087(CHEMBL3958838)
Affinity DataIC50: 1.90nMAssay Description:Inverse agonist activity at human A2A receptor assessed as inhibition of cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50067188(CHEMBL3401747)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human PDE5A1 expressed in baculovirus in sf9 cells by PDE Glo phosphodiesterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50217448(trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]b...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant sEHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50587756(CHEMBL5206601)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of equine serum BuchE preincubated for 6 mins followed by substrate addition using butyrylthiocholine iodide as substrate by DTNB reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50587756(CHEMBL5206601)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of equine serum BuchE preincubated for 6 mins followed by substrate addition using butyrylthiocholine iodide as substrate by DTNB reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50067194(CHEMBL3401753)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human PDE5A1 expressed in baculovirus in sf9 cells by PDE Glo phosphodiesterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50250823(CHEMBL4065940)
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50587755(CHEMBL5171929)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of equine serum BuchE preincubated for 6 mins followed by substrate addition using butyrylthiocholine iodide as substrate by DTNB reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50587755(CHEMBL5171929)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of equine serum BuchE preincubated for 6 mins followed by substrate addition using butyrylthiocholine iodide as substrate by DTNB reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50067198(CHEMBL3401757)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human PDE5A1 expressed in baculovirus in sf9 cells by PDE Glo phosphodiesterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50644540(CHEMBL3781002)
Affinity DataIC50: 3.40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50644540(CHEMBL3781002)
Affinity DataIC50: 3.40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50067189(CHEMBL3401748)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human PDE5A1 expressed in baculovirus in sf9 cells by PDE Glo phosphodiesterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin) using YSPTSPSYSPTSPSYSPTSPKKK as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50570985(CHEMBL4872387)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50570984(CHEMBL4847613)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50570979(CHEMBL4876038)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50570980(CHEMBL4847624)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50570986(CHEMBL4864555)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50570983(CHEMBL4857592)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50570982(CHEMBL4849196)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50570981(CHEMBL4869398)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50067190(CHEMBL3401749)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human PDE5A1 expressed in baculovirus in sf9 cells by PDE Glo phosphodiesterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
New York University

Curated by ChEMBL
LigandPNGBDBM50036722(3-[4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl...)
Affinity DataIC50: 4nMAssay Description:Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]haloperidol in the presence of 25 nM unlabeled spiperoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50250815(CHEMBL4089950)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50250837(CHEMBL4063017)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetAlpha-amylase 1A(Human)
IK Gujral Punjab Technical University

Curated by ChEMBL
LigandPNGBDBM50643502(CHEMBL5569042)
Affinity DataIC50: 4.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCholinesterase(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50587756(CHEMBL5206601)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human BuchE preincubated for 6 mins followed by substrate addition using butyrylthiocholine iodide as substrate by DTNB reagent based E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCholinesterase(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50587756(CHEMBL5206601)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human BuchE preincubated for 6 mins followed by substrate addition using butyrylthiocholine iodide as substrate by DTNB reagent based E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50570984(CHEMBL4847613)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50570981(CHEMBL4869398)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
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