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TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 0.251nMAssay Description:Binding affinity to full-length BRD4 short isoform (unknown origin) by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 7(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50183448(CHEMBL3823478 | US11773085, Compound B2)
Affinity DataKd:  0.316nMAssay Description:Binding affinity to BRD7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human BRD4 bromodomain 1/2 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human BRD4 bromodomain 1 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of human BRD3 bromodomain 1 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50183448(CHEMBL3823478 | US11773085, Compound B2)
Affinity DataKd:  0.794nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain and PHD finger-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 1nMAssay Description:Inhibition of human BRPF3 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 7(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human BRD7 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50147620(CHEMBL3769507)
Affinity DataKd:  2nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50540499(CHEMBL4635496)
Affinity DataKd:  2nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 2nMAssay Description:Inhibition of human BRD3 bromodomain 2 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50147620(CHEMBL3769507)
Affinity DataKi:  2nMAssay Description:Binding affinity to human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human BRD4 bromodomain 2 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human BRD2 bromodomain 2 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 4nMAssay Description:Inhibition of human BRPF1 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataKd:  4.40nMAssay Description:Binding affinity to His6-tagged BRD4 (1 to 477 aa) (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  6nMAssay Description:Binding affinity against DKC1 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50183449(CHEMBL3823101 | US11773085, Compound B23)
Affinity DataKd:  6.30nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  8nMAssay Description:Binding affinity against NAF1 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetArginine/serine-rich protein PNISR(Homo sapiens)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  8nMAssay Description:Binding affinity against SFRS18 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  9nMAssay Description:Binding affinity against HSP90AA1 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50: 10nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of PPIG (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50: 10nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD1 (1 to 435 residues)/BD2 Y348A mutant expressed in Escher...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of GPATCH8 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetRNA-binding protein 39(Homo sapiens)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  10nMAssay Description:Binding affinity against RBM39 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of DKC1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetLupus La protein(Homo sapiens)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of SSB (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetNucleophosmin(Human)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of NPM1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataKd:  10nMAssay Description:Binding affinity to N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escherichia coli by surface plasmon reson...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPinin(Homo sapiens)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of PNN (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDGF2 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50540525(CHEMBL4642341)
Affinity DataKi:  10nMAssay Description:Binding affinity to human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTreacle protein(Homo sapiens)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of TCOF1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  11nMAssay Description:Binding affinity against PPIG (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetNuclear receptor corepressor 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50437809(CHEMBL2407717)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant HDAC3-NCoR1 (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  12nMAssay Description:Binding affinity against GPATCH8 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetNuclear receptor corepressor 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50437812(CHEMBL2407723)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant HDAC3-NCoR1 (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50: 13nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD1 (1 to 473 residues)/BD2 Y386A mutant expressed in Escher...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50578787(CHEMBL4874801)
Affinity DataIC50: 13nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal 6His-tagged BRD4-BD1 Y390A mutant (1 to 477 residue) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAF4/FMR2 family member 1(Homo sapiens)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  13nMAssay Description:Binding affinity against AFF1 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetNuclear receptor corepressor 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50437821(CHEMBL2407736)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant HDAC3-NCoR1 (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProtein SON(Homo sapiens)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  14nMAssay Description:Binding affinity against SON (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetRNA-binding protein 25(Homo sapiens)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  14nMAssay Description:Binding affinity against RBM25 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetChromatin-remodeling ATPase INO80(Homo sapiens)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  15nMAssay Description:Binding affinity against INO80 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetPinin(Homo sapiens)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  15nMAssay Description:Binding affinity against PNN (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  15nMAssay Description:Binding affinity against HDGF2 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  15nMAssay Description:Binding affinity against CWC22 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50: 16nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD2 (1 to 435 residues)/BD1 Y73A mutant expressed in Escheri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNuclear receptor corepressor 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50437816(CHEMBL2407719)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant HDAC3-NCoR1 (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
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