Compile Data Set for Download or QSAR
Report error Found 4209 with Last Name = 'souers' and Initial = 'aj'
TargetApoptosis regulator Bcl-2(Mouse)
Abbvie

US Patent
LigandPNGBDBM178731(US9125913, 300)
Affinity DataAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM139041(US8883784, 2)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to N-terminal GST-tagged BCL-XL (unknown origin) assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM139040(US8883784, 1)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to N-terminal GST-tagged BCL-XL (unknown origin) assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50339777((R)-N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)pipera...)
Affinity DataKd:  4.20nMAssay Description:Binding affinity to Bcl-XlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKd:  0.370nMAssay Description:Binding affinity to Bcl-XlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50020929(CHEMBL3287292)
Affinity DataKd:  38nMAssay Description:Binding affinity to GST-tagged Bcl-Xl (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50020930(CHEMBL3287293)
Affinity DataKd:  10nMAssay Description:Binding affinity to GST-tagged Bcl-Xl (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50020938(CHEMBL3287301)
Affinity DataKd: <5nMAssay Description:Binding affinity to GST-tagged Bcl-Xl (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50020929(CHEMBL3287292)
Affinity DataKd: >2.00E+4nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50020930(CHEMBL3287293)
Affinity DataKd:  9.20E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50020938(CHEMBL3287301)
Affinity DataKd:  4.40E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50020929(CHEMBL3287292)
Affinity DataKd: >2.00E+4nMAssay Description:Binding affinity to Bcl-w (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50020930(CHEMBL3287293)
Affinity DataKd:  7.80E+3nMAssay Description:Binding affinity to Bcl-w (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50020938(CHEMBL3287301)
Affinity DataKd:  62nMAssay Description:Binding affinity to Bcl-w (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
LigandPNGBDBM50020929(CHEMBL3287292)
Affinity DataKd: >2.00E+4nMAssay Description:Binding affinity to Mcl-1 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
LigandPNGBDBM50020930(CHEMBL3287293)
Affinity DataKd: >2.00E+4nMAssay Description:Binding affinity to Mcl-1 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
LigandPNGBDBM50020938(CHEMBL3287301)
Affinity DataKd:  1.44E+4nMAssay Description:Binding affinity to Mcl-1 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030763(CHEMBL3342188)
Affinity DataKd:  4.00E+6nMAssay Description:Binding affinity to BCL-XL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030764(CHEMBL3342187)
Affinity DataEC50:  48nMAssay Description:Inhibition of BCL-XL (unknown origin) expressed in mcl-1 deficient MEF assessed as induction of cell killing in presence of 10% FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030750(CHEMBL3342189)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of BCL-XL (unknown origin) expressed in mcl-1 deficient MEF assessed as induction of cell killing incubated for 48 hrs in presence of 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030749(CHEMBL3342190)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of BCL-XL (unknown origin) expressed in mcl-1 deficient MEF assessed as induction of cell killing incubated for 48 hrs in presence of 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030762(CHEMBL3342191)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of BCL-XL (unknown origin) expressed in mcl-1 deficient MEF assessed as induction of cell killing incubated for 48 hrs in presence of 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030761(CHEMBL3342192)
Affinity DataEC50:  60nMAssay Description:Inhibition of BCL-XL (unknown origin) expressed in mcl-1 deficient MEF assessed as induction of cell killing incubated for 48 hrs in presence of 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030760(CHEMBL3342193)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of BCL-XL (unknown origin) expressed in mcl-1 deficient MEF assessed as induction of cell killing incubated for 48 hrs in presence of 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030759(CHEMBL3342194)
Affinity DataEC50:  640nMAssay Description:Inhibition of BCL-XL (unknown origin) expressed in mcl-1 deficient MEF assessed as induction of cell killing incubated for 48 hrs in presence of 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030758(CHEMBL3342195)
Affinity DataEC50:  10nMAssay Description:Inhibition of BCL-XL (unknown origin) expressed in mcl-1 deficient MEF assessed as induction of cell killing incubated for 48 hrs in presence of 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030757(CHEMBL3342196)
Affinity DataEC50:  20nMAssay Description:Inhibition of BCL-XL (unknown origin) expressed in mcl-1 deficient MEF assessed as induction of cell killing incubated for 48 hrs in presence of 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50152472(N-[3-(2-Amino-quinolin-8-yloxy)-propyl]-3-chloro-b...)
Affinity DataIC50: 0.400nMAssay Description:Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50152479(1-[3-(2-Amino-quinolin-8-yloxy)-propyl]-3-(3-chlor...)
Affinity DataIC50: 0.900nMAssay Description:Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50152494(8-[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-pyrrolid...)
Affinity DataIC50: 0.900nMAssay Description:Concentration required to inhibit binding of [125I]MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50152463(8-[3-(2,2-Difluoro-benzo[1,3]dioxol-5-ylamino)-pro...)
Affinity DataIC50: 1nMAssay Description:Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50152481(8-[2-(3-Methoxy-benzylamino)-1-methyl-ethoxy]-quin...)
Affinity DataIC50: 1nMAssay Description:Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50152486(3-Chloro-N-[3-(2-{[5-(2-chloro-phenyl)-furan-2-ylm...)
Affinity DataIC50: 1nMAssay Description:Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50152495(8-[(S)-1-(4-tert-Butyl-benzyl)-pyrrolidin-3-yloxy]...)
Affinity DataIC50: 1nMAssay Description:Concentration required to inhibit binding of [125I]MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202681(7-fluoro-4-oxo-N-(1-((2-oxo-2H-chromen-7-yl)methyl...)
Affinity DataIC50: 1nMAssay Description:Displacement of 125I-MCH from MCH-R1 expressed in IMR-32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50020938(CHEMBL3287301)
Affinity DataIC50: 1nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50152497(8-[1-(4-Isobutyl-phenyl)-pyrrolidin-3-yloxy]-quino...)
Affinity DataIC50: 1.20nMAssay Description:Concentration required to inhibit binding of [125I]MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50162116(2-(4-(benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)e...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of melanin concentrating hormone receptor 1 from human neuronal IMR-32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50162116(2-(4-(benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)e...)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory concentration against Melanin-concentrating hormone receptor 1 in diet-induced obese miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50162116(2-(4-(benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)e...)
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125I]MCH from MCHr1 expressed in IMR32 (I3.4.2) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50167565(1-[1-(2-Isobutylamino-ethyl)-1H-indazol-5-yl]-3-(4...)
Affinity DataIC50: 1.80nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM167858(US9073922, 355)
Affinity DataIC50: 2nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM167859(US9073922, 356)
Affinity DataIC50: 2nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM167860(US9073922, 357)
Affinity DataIC50: 2nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
Go to US Patent

TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50152469(N-[3-(2-{[5-(4-Chloro-phenyl)-furan-2-ylmethyl]-am...)
Affinity DataIC50: 2nMAssay Description:Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50152480(N-[3-(2-Amino-quinolin-8-yloxy)-propyl]-3-methoxy-...)
Affinity DataIC50: 2nMAssay Description:Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50171590(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-yl)-5...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity towards melanin-concentrating hormone receptor 1 in IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50173461(4-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-ylami...)
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration aganist melanin concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50171590(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-yl)-5...)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MCH from MCHr1 expressed in IMR32 (I3.4.2) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50173460(4-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-y...)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MCH from MCHr1 expressed in IMR32 (I3.4.2) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Displayed 1 to 50 (of 4209 total ) | Next | Last >>
Jump to: