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TargetS-sulfocysteine synthase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50615371(CHEMBL4786399)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of hexahistidine-tagged recombinant Mycobacterium tuberculosis CysK2 expressed in Escherichia coli BL21(DE3) assessed as inhibition consta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50427257(CHEMBL2325118)
Affinity DataKi:  5.00E+3nMAssay Description:Competitive inhibition of Mycobacterium tuberculosis CysK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50427257(CHEMBL2325118)
Affinity DataKi:  5.00E+3nMAssay Description:Competitive inhibition of Mycobacterium tuberculosis CysK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human DHFR assessed as reduction in consumption of NADPH using DHF as substrate preincubated for 1 min followed by DHF addition and mea...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFR expressed in Escherichia coli BL21(DE3) assessed as reduction in consumption of NADPH using DHF a...More data for this Ligand-Target Pair
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439141(CHEMBL2418481)
Affinity DataIC50:  19nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439146(CHEMBL2418529)
Affinity DataIC50:  26nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Birla Institute of Technology & Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50226181((3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase-mediated supercoiling of relaxed DNA using pBR 322 as substrate by agarose gel electrophoresis analysi...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Staphylococcus aureus)
Birla Institute of Technology

LigandPNGBDBM282((3R,4S,5R,6R)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydrox...)
Affinity DataIC50:  30nMpH: 7.6 T: 25°CAssay Description:Supercoiling assay was performed using the commercially available kit (DNA gyrase supercoiling assay kit: SAS4001) from Inspiralis Pvt.limited, Norwi...More data for this Ligand-Target Pair
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439147(CHEMBL2418524)
Affinity DataIC50:  34nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439140(CHEMBL2418487)
Affinity DataIC50:  37nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50226181((3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-...)
Affinity DataIC50:  46nMAssay Description:Inhibition of Mycobacterium smegmatis 155 6His-tagged DNA gyrase B catalytic domain ATPase activity expressed in Escherichia coli BL21 (DE3) pLysS ce...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Institute of Technology & Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50226181((3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-...)
Affinity DataIC50:  46nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of DNA supercoiling after 30 mins by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50423645(Albamycin | Cathomycin | NOVOBIOCIN)
Affinity DataIC50:  46nMT: 25°CAssay Description:Inhibition of Mycobacterium smegmatis DNA GyrB domain assessed as inhibition of inorganic phosphate release after 100 mins at room temperature by ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rat)
Birla Institute of Technology & Science - Pilani

Curated by ChEMBL
LigandPNGBDBM50492813(CHEMBL2414609)
Affinity DataIC50:  50nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in rat brain homogenate after 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439143(CHEMBL2418504)
Affinity DataIC50:  54nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439142(CHEMBL2418505)
Affinity DataIC50:  56nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439144(CHEMBL2418502)
Affinity DataIC50:  60nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439152(CHEMBL2418568)
Affinity DataIC50:  63nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439139(CHEMBL2418489)
Affinity DataIC50:  70nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50104286(CHEMBL3593715)
Affinity DataIC50:  71nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50104286(CHEMBL3593715)
Affinity DataIC50:  71nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439150(CHEMBL2418545)
Affinity DataIC50:  95nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate lyase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50351206(CHEMBL1818383)
Affinity DataIC50:  100nMAssay Description:Inhibition of Mycobacterium tuberculosis isocitrate lyaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439151(CHEMBL2418569)
Affinity DataIC50:  101nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439138(CHEMBL2418558)
Affinity DataIC50:  103nMAssay Description:Inhibition of Mycobacterium tuberculosis CysK1More data for this Ligand-Target Pair
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439149(CHEMBL2418548)
Affinity DataIC50:  110nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate lyase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50351204(CHEMBL1818381)
Affinity DataIC50:  120nMAssay Description:Inhibition of Mycobacterium tuberculosis isocitrate lyaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Staphylococcus aureus)
Birla Institute of Technology

LigandPNGBDBM282((3R,4S,5R,6R)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydrox...)
Affinity DataIC50:  125nMpH: 7.5Assay Description:Initially, equimolar quantities of about 0.5µM each of E. coli gyraseA and S. aureus gyraseB were incubated for a period of 45 min with salmon sperm ...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Staphylococcus aureus)
Birla Institute of Technology

LigandPNGBDBM50226181((3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-...)
Affinity DataIC50:  125nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B ATPase activityMore data for this Ligand-Target Pair
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439148(CHEMBL2418551)
Affinity DataIC50:  141nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50104288(CHEMBL3594137)
Affinity DataIC50:  150nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50104288(CHEMBL3594137)
Affinity DataIC50:  155nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO-acetylserine sulfhydrylase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50439145(CHEMBL2418514)
Affinity DataIC50:  160nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50226181((3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B expressed in Escherichia coli BL21 (DE3) pLysS cells assessed as reduction in ATPase activity incu...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50226181((3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of 6-His-tagged Mycobacterium smegmatis GyrB expressed in Escherichia coli BL21 (DE3) pLysS cells incubated for 100 mins in presence of AT...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50423645(Albamycin | Cathomycin | NOVOBIOCIN)
Affinity DataIC50:  180nMAssay Description:Inhibition of purified Mycobacterium smegmatis GyrB at 50 to 100 uM after 100 mins by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM282((3R,4S,5R,6R)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydrox...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Mycobacterium smegmatis GyrB ATPase activity expressed in Escherichia coli BL21 (DE3) pLysS cells after 100 mins by inorganic phosphate...More data for this Ligand-Target Pair
TargetIsocitrate lyase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Institute of Technology and Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50351203(CHEMBL1818380)
Affinity DataIC50:  200nMAssay Description:Inhibition of Mycobacterium tuberculosis isocitrate lyaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50423645(Albamycin | Cathomycin | NOVOBIOCIN)
Affinity DataIC50:  200nMAssay Description:Inhibition of Mycobacterium smegmatis GyrB ATPase activity expressed in Escherichia coli BL21 (DE3) after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50104287(CHEMBL3594136)
Affinity DataIC50:  230nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50104287(CHEMBL3594136)
Affinity DataIC50:  234nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Birla Institute of Technology & Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50483330(CHEMBL1651595)
Affinity DataIC50:  250nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Birla Institute of Technology & Science-Pilani

Curated by ChEMBL
LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Affinity DataIC50:  250nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Institute of Technology & Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50500052(CHEMBL3740531)
Affinity DataIC50:  290nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of supercoiling activity using relaxed pBR322 plasmid as substrate after 3...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50104285(CHEMBL3593716)
Affinity DataIC50:  300nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50104285(CHEMBL3593716)
Affinity DataIC50:  302nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Institute of Technology & Science-Pilani

Curated by ChEMBL
LigandPNGBDBM50500046(CHEMBL3742062)
Affinity DataIC50:  320nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of supercoiling activity using relaxed pBR322 plasmid as substrate after 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50104290(CHEMBL268379)
Affinity DataIC50:  355nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50104290(CHEMBL268379)
Affinity DataIC50:  360nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
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