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LigandPNGBDBM50328707(CHEMBL4173664)
Affinity DataEC50:  42nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329878(CHEMBL4162299)
Affinity DataEC50:  75nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329877(CHEMBL4161243)
Affinity DataEC50:  25nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329884(CHEMBL4166451)
Affinity DataEC50:  312nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329883(CHEMBL4177077)
Affinity DataEC50:  516nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50330199(CHEMBL4173709)
Affinity DataEC50:  60nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50327369(CHEMBL4172962)
Affinity DataEC50:  278nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProtein ENL(Human)
Sanders Tri-Institutional Therapeutics

Curated by ChEMBL
LigandPNGBDBM50623073(CHEMBL5410133)
Affinity DataKd:  160nMAssay Description:Binding affinity to ENL YEATS domain (unknown origin) at 100 uM by ITC analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50329820(CHEMBL4165734)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329883(CHEMBL4177077)
Affinity DataEC50:  188nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329109(CHEMBL4167676)
Affinity DataEC50:  43nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProtein ENL(Human)
Sanders Tri-Institutional Therapeutics

Curated by ChEMBL
LigandPNGBDBM50617567(CHEMBL5395794)
Affinity DataKd:  120nMAssay Description:Binding affinity to ENL YEATS domain (unknown origin) at 100 uM by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50328707(CHEMBL4173664)
Affinity DataEC50:  5.10nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50330179(CHEMBL4169168)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50327371(CHEMBL4159767)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50327370(CHEMBL4177039)
Affinity DataEC50:  21nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50327370(CHEMBL4177039)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329820(CHEMBL4165734)
Affinity DataEC50:  58nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329884(CHEMBL4166451)
Affinity DataEC50:  49nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50330179(CHEMBL4169168)
Affinity DataEC50:  113nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329107(CHEMBL4162958)
Affinity DataEC50:  67nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50327371(CHEMBL4159767)
Affinity DataEC50:  58nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300240(3-(3-chlorophenethyl)pyridin-2-amine | 3-[2-(3-chl...)
Affinity DataKd:  3.20E+4nMAssay Description:Binding affinity to BACE1 by fragment-based NMR screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
LigandPNGBDBM50327545(CHEMBL4163003)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50327769(CHEMBL4174762)
Affinity DataEC50:  248nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329880(CHEMBL4164666)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50327372(CHEMBL4176348)
Affinity DataEC50:  44nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50330199(CHEMBL4173709)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50327369(CHEMBL4172962)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329107(CHEMBL4162958)
Affinity DataEC50:  3.5nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProtein ENL(Human)
Sanders Tri-Institutional Therapeutics

Curated by ChEMBL
LigandPNGBDBM50529556(CHEMBL4552313)
Affinity DataKd:  100nMAssay Description:Binding affinity to ENL YEATS domain (unknown origin) at 100 uM by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50329109(CHEMBL4167676)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329878(CHEMBL4162299)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300238(2-ethylhex-2-enyl carbamimidothioate | CHEMBL57523...)
Affinity DataKd:  5.50E+5nMAssay Description:Binding affinity to BACE1 by fragment-based NMR screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
LigandPNGBDBM50327769(CHEMBL4174762)
Affinity DataEC50:  212nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50327883(CHEMBL4172551)
Affinity DataEC50:  97nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50329877(CHEMBL4161243)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50327372(CHEMBL4176348)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50327545(CHEMBL4163003)
Affinity DataEC50:  60nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50327883(CHEMBL4172551)
Affinity DataEC50:  0.427nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM114543(carbamimidothioic acid (4-butoxy-3-chlorophenyl)me...)
Affinity DataKd:  1.50E+4nMAssay Description:Binding affinity to BACE1 by fragment-based NMR screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
LigandPNGBDBM50329880(CHEMBL4164666)
Affinity DataEC50:  46nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Merck

Curated by ChEMBL
LigandPNGBDBM50280116(CHEMBL4177355)
Affinity DataIC50: 0.0120nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli using Val-Ser-Gln-Asn-(beta-naphtyl)Ala-Pro-Ile-Val as substrate preincubated for 30 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Merck

Curated by ChEMBL
LigandPNGBDBM8125(Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...)
Affinity DataIC50: 0.0130nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli using Val-Ser-Gln-Asn-(beta-naphtyl)Ala-Pro-Ile-Val as substrate preincubated for 30 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Merck

Curated by ChEMBL
LigandPNGBDBM13934(CGP 73547 | CHEMBL1163 | methyl N-[(1S)-1-{[(2S,3S...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli using Val-Ser-Gln-Asn-(beta-naphtyl)Ala-Pro-Ile-Val as substrate preincubated for 30 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM684597(US20240226096, Example I-15 | 1-(3'-(5-(4-(tert- b...)
Affinity DataIC50: 0.152nMAssay Description:3x Complete Substrate plus Inhibitor Solution in Assay Medium (Opti-MEM I Reduced Serum Medium, no phenol red, and no serum) was prepared just before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM684583(US20240226096, Example I-2 | US20240226096, Exampl...)
Affinity DataIC50: 0.152nMAssay Description:3x Complete Substrate plus Inhibitor Solution in Assay Medium (Opti-MEM I Reduced Serum Medium, no phenol red, and no serum) was prepared just before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
Go to US Patent

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14776(CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120086(8-Cyclohexylamino-1,3-diethyl-7-(3-fluoro-4-methox...)
Affinity DataIC50: 0.300nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140583(5-ethyl-3-(4-hydroxybenzyl)-2-(2-phenyl-1-ethynyl)...)
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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