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TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312283((+/-)-cis-N-(1-benzoyl-2-methyl-1,2,3,4-tetrahydro...)
Affinity DataEC50:  11nMAssay Description:Antagonist activity at human CRTH2 receptor expressed in CEM cell assessed as inhibition of PGD2-induced cell migration after 3 hrs by transwell migr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50236955(CHEMBL4059677)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of human CYP1B1 expressed in HEK293 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin EC50 at 0.02 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50014323(CHEMBL283196 | alpha-naphthoflavone | 2-PHENYL-4H-...)
Affinity DataEC50:  3.50E+4nMAssay Description:Inhibition of human CYP1B1 expressed in human A2780 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin EC50 at 0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 1B1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50014323(CHEMBL283196 | alpha-naphthoflavone | 2-PHENYL-4H-...)
Affinity DataEC50:  4.00E+4nMAssay Description:Inhibition of human CYP1B1 expressed in HEK293 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin EC50 at 0.016 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 1B1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50236947(CHEMBL4092737)
Affinity DataEC50:  8.30E+3nMAssay Description:Inhibition of human CYP1B1 expressed in HEK293 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin EC50 at 0.018 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50236955(CHEMBL4059677)
Affinity DataEC50:  500nMAssay Description:Inhibition of human CYP1B1 expressed in human A2780 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin EC50 at 0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50236947(CHEMBL4092737)
Affinity DataEC50:  3.30E+3nMAssay Description:Inhibition of human CYP1B1 expressed in human A2780 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin EC50 at 0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50360680(CHEMBL1933918)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302824(2-(4-(2-(2,4-dichlorophenylsulfonamido)-4-(ethylca...)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50360682(CHEMBL1933920)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50360681(CHEMBL1933919)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50360679(CHEMBL1933917)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364536(CHEMBL1950879)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364525(CHEMBL1950868)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364535(CHEMBL1950878)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364528(CHEMBL1950871)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312289(4-(((2S,4R)-1-benzoyl-2-methyl-1,2,3,4-tetrahydroq...)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50360668(CHEMBL1933763)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]PGD2 from human DP receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363928(CHEMBL1951575)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363935(CHEMBL1951562)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302828(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364524(CHEMBL1950867)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50378984(CHEMBL2011450)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]-PGH2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of buffer containing 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50360671(CHEMBL1933766)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363923(CHEMBL1951570)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363917(CHEMBL1951566)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302832(2-(4-(4-(cyclopropylcarbamoyl)-2-(2,4-dichlorophen...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363934(CHEMBL1951561)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50360671(CHEMBL1933766)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363928(CHEMBL1951575)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364536(CHEMBL1950879)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]PGD2 from human DP receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364534(CHEMBL1950877)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50236955(CHEMBL4059677)
Affinity DataIC50: 4nMAssay Description:Inhibition of human liver CYP1B1 expressed in HEK293 cells using CEC as substrate preincubated for 30 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50236947(CHEMBL4092737)
Affinity DataIC50: 4nMAssay Description:Inhibition of human liver CYP1B1 expressed in HEK293 cells using CEC as substrate preincubated for 30 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312278((+/-)-4-((1-benzoyl-2-methyl-1,2,3,4-tetrahydroqui...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50360675(CHEMBL1933913)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363926(CHEMBL1951573)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363922(CHEMBL1951569)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363921(CHEMBL1951568)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363929(CHEMBL1951556)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364527(CHEMBL1950870)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364527(CHEMBL1950870)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]PGD2 from human DP receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50378985(CHEMBL2011449)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-PGH2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of buffer containing 0.5% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50014323(CHEMBL283196 | alpha-naphthoflavone | 2-PHENYL-4H-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human CYP1B1 expressed in human AHH1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50360680(CHEMBL1933918)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by scintillation counting in presence of 50 % human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50360670(CHEMBL1933765)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]PGD2 from human DP receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363936(CHEMBL1951563)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363919(CHEMBL1951402)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50363935(CHEMBL1951562)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
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