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TargetEukaryotic initiation factor 4A-I(Human)
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50196926(Rocaglamide | CHEMBL438139 | US10085988, Compound ...)
Affinity DataKd:  156nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic initiation factor 4A-I(Human)
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(Zotatifin | Eft226 | EFT-226)
Affinity DataKd:  21nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetEukaryotic initiation factor 4A-I(Human)
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(Zotatifin | Eft226 | EFT-226)
Affinity DataKd:  3.19E+3nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetEukaryotic initiation factor 4A-I(Human)
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(Zotatifin | Eft226 | EFT-226)
Affinity DataKd:  9.60E+3nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetEukaryotic initiation factor 4A-I(Human)
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(Zotatifin | Eft226 | EFT-226)
Affinity DataKd:  2.43E+3nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM50263270(CHEMBL4086747)
Affinity DataIC50: 0.0840nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707580(US20240409609, Compound 110)
Affinity DataIC50: 0.119nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707579(US20240409609, Compound 109)
Affinity DataIC50: 0.125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM50263254(CHEMBL4094975)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM50263253(CHEMBL4067557)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707526(US20240409609, Compound 51)
Affinity DataIC50: 0.147nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707527(US20240409609, Compound 52)
Affinity DataIC50: 0.187nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707528(US20240409609, Compound 53)
Affinity DataIC50: 0.275nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707529(US20240409609, Compound 55)
Affinity DataIC50: 0.307nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM168214(US9669031, 207 6′-((6-aminopyrimidin-4-yl)am...)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707531(US20240409609, Compound 57)
Affinity DataIC50: 0.315nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM50263270(CHEMBL4086747)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Terremoto Biosciences

US Patent
LigandPNGBDBM707579(US20240409609, Compound 109)
Affinity DataIC50: 0.406nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707532(US20240409609, Compound 58)
Affinity DataIC50: 0.422nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707533(US20240409609, Compound 59)
Affinity DataIC50: 0.424nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707534(US20240409609, Compound 60)
Affinity DataIC50: 0.438nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM168214(US9669031, 207 6′-((6-aminopyrimidin-4-yl)am...)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707535(US20240409609, Compound 61)
Affinity DataIC50: 0.515nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707536(US20240409609, Compound 62)
Affinity DataIC50: 0.520nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707537(US20240409609, Compound 63)
Affinity DataIC50: 0.526nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707539(US20240409609, Compound 65)
Affinity DataIC50: 0.616nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM50263254(CHEMBL4094975)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707538(US20240409609, Compound 64)
Affinity DataIC50: 0.623nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707540(US20240409609, Compound 66)
Affinity DataIC50: 0.629nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM50263269(CHEMBL4076439)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM50263269(CHEMBL4076439)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM50263269(CHEMBL4076439)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Terremoto Biosciences

US Patent
LigandPNGBDBM707526(US20240409609, Compound 51)
Affinity DataIC50: 0.795nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM50263254(CHEMBL4094975)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707541(US20240409609, Compound 68)
Affinity DataIC50: 0.899nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707577(US20240409609, Compound 107)
Affinity DataIC50: 0.904nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707542(US20240409609, Compound 69)
Affinity DataIC50: 0.911nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707543(US20240409609, Compound 70)
Affinity DataIC50: 0.972nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM50263255(CHEMBL4065802)
Affinity DataIC50: 1nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)
Affinity DataIC50: 1nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707544(US20240409609, Compound 71)
Affinity DataIC50: 1.08nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707545(US20240409609, Compound 72)
Affinity DataIC50: 1.11nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707546(US20240409609, Compound 73)
Affinity DataIC50: 1.12nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707547(US20240409609, Compound 74)
Affinity DataIC50: 1.16nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707548(US20240409609, Compound 75)
Affinity DataIC50: 1.19nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707549(US20240409609, Compound 76)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Terremoto Biosciences

US Patent
LigandPNGBDBM707580(US20240409609, Compound 110)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM168216(US9669031, 79 3,3-dimethyl-6-(pyrimidin-4-ylamino)...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM168222(US9669031, 93 6-[(6-aminopyrimidin-4-yl)amino]-8-c...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Terremoto Biosciences

US Patent
LigandPNGBDBM707536(US20240409609, Compound 62)
Affinity DataIC50: 1.23nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

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